US4840939A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of cancer with phlorizin and its derivatives
Assignee: Individual
•
Filing: 1987-03-18
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Granted: 1989-06-20
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Expires: 2007-03-18
Abstract
Abstract Malignant, neoplastic cells are treated by inhibiting glucose transport into the cell by administering phlorizin, phloretin or its analogs while concurrently administering adjunct therapy such as heat, radiation or chemotherapy. In this manner, the cells are prevented from growing or repairing the damage caused by the adjunct therapy, which can be administered in dosages that would otherwise be non-lethal if used alone.
Inventors
- 👤 Harry H. Leveen
- 👤 Robert F. Leveen
- 👤 Eric G. LeVeen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:49
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/7004; A61K31/12; A61K31/33; A61K31/395; A61K31/40; A61K31/403; A61K31/4035; C; C07; C07H; C07H17/00; C07H17/04; C07H17/06; C07H17/065; C07H17/07
Claims Analysis
Total Claims: 32
Claim 1
Independent Claim
38 words
A method for inhibiting glucose transport into malignant neoplastic cells which comprises administering an effective amount of a compound or compounds selected from the group consisting of phlorizin, phloretin, phlorizin glucoronide, 4-deoxyphloretin-2-D-glucose, and cytochalasin-B to a human being.
Claim 2
Independent Claim
38 words
A method for inhibiting glucose transport into malignant neoplastic cells which comprises administering an effective amount of a compound or compounds selected from the group consisting of phlorizin, phloretin, phlorizin glucoronide, 4-deoxyphloretin-2-D-glucose, and cytochalasin-B to a human being.
Claim 3
Dependent Claim
28 words
The method of claim 1 wherein said compound or compounds are administered in combination with a chemotherapeutic agent selected from the group consisting of lonidamine, bleomycin and mytomycin.
Claim 4
Independent Claim
47 words
A method for treatment of malignant neoplastic cells in a human being which comprises inhibiting glucose transport into said cells by administering to said human being an effective amount of a compound or compounds selected from the group consisting of phlorizin, phlorizin glucoronide, phloretin, 4-deoxyphloretin-2-D-glucose, and cytochalasin-B.
Claim 5
Independent Claim
47 words
A method for treatment of malignant neoplastic cells in a human being which comprises inhibiting glucose transport into said cells by administering to said human being an effective amount of a compound or compounds selected from the group consisting of phlorizin, phlorizin glucoronide, phloretin, 4-deoxyphloretin-2-D-glucose, and cytochalasin-B.
Claim 6
Dependent Claim
31 words
The method of claim 1 wherein said compound or compounds are administered in combination with a chemotherapeutic agent selected from the group consisting of lonidamine, bleomycin and mytomycin, 5-flurouricil, and cysplatinum.
Claim 7
Dependent Claim
31 words
The method of claim 1 wherein said compound or compounds is administered in a total amount of about 200 to 1000 mg per kilogram of body weight of said human being.
Claim 8
Dependent Claim
31 words
The method of claim 3 wherein said compound or compounds are administered in combination with a chemotherapeutic agent selected from the group consisting of lonidamine, bleomycin and mytomycin, 5-flurouricil, and cysplatinum.
Claim 9
Dependent Claim
13 words
The method of claim 6 wherein said compound or compounds is administered intravenously.
Claim 10
Dependent Claim
30 words
The method of claim 7 wherein said compound or compounds is administered initially as a dosage sufficient to block glucose transport into said cells followed by a continuous maintenance dosage.
Claim 11
Dependent Claim
38 words
The method of claim 8 wherein said initial dosage is about 4-6 mg per kilogram of body weight and said maintenance dose is administered at a rate of about 1 mg per hour per kilogram of body weight.
Claim 12
Dependent Claim
22 words
The method of claim 7 wherein said compound or compounds is administered intravenously from a saline solution of said compound or compounds.
Claim 13
Dependent Claim
31 words
The method of claim 3 wherein administering of said compound or compounds is done concurrently with subjecting said cells to additional therapy in the form of chemotherapy, thermal or radiation therapy.
Claim 14
Dependent Claim
28 words
The method of claim 11 wherein said compound or compounds is administered in combination with a chemotherapeutic agent selected from the group consisting of lonidamine, bleomycin and mytomycin.
Claim 15
Dependent Claim
31 words
The method of claim 11 wherein said compound or compounds is administered in a total amount of about 200 to 1000 mg per kilogram of body weight of said human being.
Claim 16
Independent Claim
71 words
A method for treatment of malignant neoplastic cells in humans which comprises administering one or more compounds selected from the group consisting of phlorizin, phlorizin glucoronide, 4-deoxyphloretin-2-D-glucose in an amount effective to inhibit glucose transport in the cells along with one or more additional compounds selected from the group consisting of lonidamine, bleomycin and mytomycin while subjecting said cells to additional therapy in the form of chemotherapy, thermal or radiation therapy.
Claim 17
Independent Claim
71 words
A method for treatment of malignant neoplastic cells in humans which comprises administering one or more compounds selected from the group consisting of phlorizin, phlorizin glucoronide, 4-deoxyphloretin-2-D-glucose in an amount effective to inhibit glucose transport in the cells along with one or more additional compounds selected from the group consisting of lonidamine, bleomycin and mytomycin while subjecting said cells to additional therapy in the form of chemotherapy, thermal or radiation therapy.
Claim 18
Dependent Claim
48 words
The method of claim 14 wherein the dosage of said one or more compounds is an effective amount of at least 200-1000 mg per kg of body weight and the dosage of said additional one or more compounds is 50 to 500 mg per kilo of body weight.
Claim 19
Dependent Claim
19 words
The method of claim 15 wherein said one or more compounds are administered intravenously concurrently with said additional therapy.
Claim 20
Independent Claim
32 words
A method for treatment of neoplastic cells in humans which comprises administering phloretin in an effective amount to inhibit glucose transport in the cells while concurrently subjecting said cells to thermal treatment.
Claim 21
Independent Claim
32 words
A method for treatment of neoplastic cells in humans which comprises administering phloretin in an effective amount to inhibit glucose transport in the cells while concurrently subjecting said cells to thermal treatment.
Claim 22
Dependent Claim
23 words
The method of claim 17 wherein said thermal treatment is at a dosage level that would otherwise be non-lethal if administered by itself.
Claim 23
Dependent Claim
29 words
The method of claim 17 wherein said phloretin is administered in combination with a chemotherapeutic agent selected from the group consisting of lonidamine, bleomycin and mytomycin, 5-flurouricil, and cisplatinum.
Claim 24
Dependent Claim
29 words
The method of claim 17 wherein said phloretin is administered in a total amount of about 200 to 1000 mg per kilogram of body weight of said human being.
Claim 25
Dependent Claim
13 words
The method of claim 17 wherein said phloretin is a compound administered intravenously.
Claim 26
Dependent Claim
28 words
The method of claim 21 wherein said compound is administered initially as a dosage sufficient to block glucose transport into said cells followed by a continuous maintenance dosage.
Claim 27
Dependent Claim
37 words
The method of claim 22 wherein said dosage is about 4-6 mg per kilogram of body weight and said maintenance dose is administered at a rate of about 1 mg per hour per kilogram of body weight.
Claim 28
Dependent Claim
17 words
The method of claim 21 wherein compound is administered intravenously from a saline solution of said compound.
Claim 29
Independent Claim
43 words
A method for treatment of malignant neoplastic cells in humans which comprises administering one or more compounds which are effective to inhibit glucose transport in the cells while subjecting said cells to additional therapy in the form of chemotherapy, thermal or radiation therapy.
Claim 30
Independent Claim
43 words
A method for treatment of malignant neoplastic cells in humans which comprises administering one or more compounds which are effective to inhibit glucose transport in the cells while subjecting said cells to additional therapy in the form of chemotherapy, thermal or radiation therapy.
Claim 31
Independent Claim
52 words
A method for treatment of malignant neoplastic cells in humans which comprises administering one or more compounds which are effective to inhibit glucose transport in the cells along with one or more additional therapeutically effective compounds while subjecting said cells to additional therapy in the form of chemotherapy, thermal or radiation therapy.
Claim 32
Independent Claim
52 words
A method for treatment of malignant neoplastic cells in humans which comprises administering one or more compounds which are effective to inhibit glucose transport in the cells along with one or more additional therapeutically effective compounds while subjecting said cells to additional therapy in the form of chemotherapy, thermal or radiation therapy.
References Cited (Backward Citations)
US3523937A
Cited
US4684627A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-06-19 | 1992-12-19 | 1993-06-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-06-19 | 1996-12-19 | 1997-06-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-06-19 | 2000-12-19 | 2001-06-20 | $7700.00 | Window Closed / Lapsed |