US4834747A
Expired / Lapsed
US
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Method of producing a multilayered prosthesis material and the material obtained
Assignee: AMS Medinvent SA
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Filing: 1985-10-28
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Granted: 1989-05-30
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Expires: 2005-10-28
Abstract
Abstract PCT No. PCT/SE85/00420 Sec. 371 Date Jun. 24, 1986 Sec. 102(e) Date Jun. 24, 1986 PCT Filed Oct. 28, 1985 PCT Pub. No. WO86/02843 PCT Pub. Date May 22, 1986.A method of producing a mono- or multilayered prosthesis material for use with a living body, the material showing mechanical compliance vis-à-vis soft body tissue and possessing biocompatibility, the method comprising the steps of: (a) preparing a polymer solution using a mixed solvent, the solution being near its precipitation point; (b) coating a substrate and precipitating thereon the polymer to form a physically stable porous structure by evaporating at least part of the solvent fraction of the mixed solvent; and the multilayered prosthesis material prepared by the method.
Inventors
- 👤 Sylwester Gogolewski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:15
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/56; A61L15/00; A61L15/16; A61L15/22; A61L15/26; A61L15/42; A61L15/425; A61L27/28; A61L27/34; Y; Y10; Y10S; Y10S623/00; Y10S623/901; Y10S623/92; Y10S623/921
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
189 words
A method of producing a multilayered prosthesis material for use with a living body, said material showing mechanical compliance vis-a-vis soft body tissue and possessing biocompatibility, said method comprising the steps of (a) preparing a solution of a biocompatible polymer using a mixed solvent, the mixed solvent including as a first constituent a solvent in which said polymer is substantially dissolvable and as a second constituent a non-solvent in which said polymer is not substantially dissolvable, said solvent and said non-solvent being substantially miscible, and said solution being near the precipitation point of said polymer; (b) applying said solution to a substrate, thereby forming a coating of said solution on said substrate; (c) precipitating the polymer in said coating by evaporating only a portion of the solvent, the amount of evaporation being such that said solution reaches the precipitation point of said polymer, the precipitate forming a physically stable porous structure, and (d) repeating steps (a), (b) and (c) in sequential fashion to form a plurality of coatings on said substrate, thereby forming the multilayered prosthesis material, said material being usable as a prosthesis when removed from said substrate.
Claim 2
Independent Claim
189 words
A method of producing a multilayered prosthesis material for use with a living body, said material showing mechanical compliance vis-a-vis soft body tissue and possessing biocompatibility, said method comprising the steps of (a) preparing a solution of a biocompatible polymer using a mixed solvent, the mixed solvent including as a first constituent a solvent in which said polymer is substantially dissolvable and as a second constituent a non-solvent in which said polymer is not substantially dissolvable, said solvent and said non-solvent being substantially miscible, and said solution being near the precipitation point of said polymer; (b) applying said solution to a substrate, thereby forming a coating of said solution on said substrate; (c) precipitating the polymer in said coating by evaporating only a portion of the solvent, the amount of evaporation being such that said solution reaches the precipitation point of said polymer, the precipitate forming a physically stable porous structure, and (d) repeating steps (a), (b) and (c) in sequential fashion to form a plurality of coatings on said substrate, thereby forming the multilayered prosthesis material, said material being usable as a prosthesis when removed from said substrate.
Claim 3
Dependent Claim
17 words
The method according to claim 1, characterized by using a copolyurethane as the polymer in step (a).
Claim 4
Dependent Claim
13 words
The method according to claim 2, wherein the polymer is a segmented copolyurethane.
Claim 5
Dependent Claim
22 words
The method according to claim 1, wherein the solvent is selected from the group consisting of tetrahydrofuran, amide solvents and sulfoxide solvents.
Claim 6
Dependent Claim
20 words
The method according to claim 1, wherein the non-solvent is selected from the group consisting of water and lower alkanols.
Claim 7
Dependent Claim
38 words
The method of claim 1, wherein the concentration of polymer in each of the plurality of solutions prepared according to step (a) is varied, thereby producing a multilayered material wherein the different layers have different average pore sizes.
Claim 8
Dependent Claim
21 words
The method of claim 1, wherein the solution prepared in step (a) contains less than about 5% by weight of polymer.
Claim 9
Dependent Claim
21 words
The method of claim 1, wherein the solution prepared in step (a) contains less than about 3% by weight of polymer.
Claim 10
Dependent Claim
17 words
The method of claim 1, wherein said solvent has a higher rate of evaporation than said non-solvent.
Claim 11
Dependent Claim
9 words
Prosthesis material prepared by the method of claim 1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1992-05-29 | 1992-11-28 | 1993-05-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-05-29 | 1996-11-28 | 1997-05-30 | $3760.00 | Window Closed / Lapsed |
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