US4816442A
Expired / Lapsed
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Method of inhibiting tumor growth sensitive to CIF-βtreatment
Assignee: Oncogen LP
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Filing: 1986-11-07
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Granted: 1989-03-28
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Expires: 2006-11-07
Abstract
Abstract Polypeptides called cartilage-inducing factors (CIFs) that are found in bone and have heretofore been identified as having in vitro cartilage-inducing activity. TGF-β activity, and anti-inflammatory activity have now been found to possess potent oncostatic activity. The CIFs showed oncostatic activity on human and animal tumors, including carcinomas, adenocarcinomas, lymphomas, and melanomas.
Inventors
- 👤 John M. McPherson
- 👤 Danile R. Twardzik
- 👤 George J. Todaro
- 👤 Karl A. Piez
- 👤 Jane E. Ranchalis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:28
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/18; A61K38/1841; A61P; A61P35/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/12
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
28 words
A method of inhibiting growth of tumor cells in a mammal comprising administering an oncostatically effective amount of CIF-B to a mammal having tumor cells sensitive to CIF-B.
Claim 2
Independent Claim
28 words
A method of inhibiting growth of tumor cells in a mammal comprising administering an oncostatically effective amount of CIF-B to a mammal having tumor cells sensitive to CIF-B.
Claim 3
Dependent Claim
19 words
The method of claim 1 wherein the tumor cells are carcinoma cells, adenocarcinoma cells, melanoma cells, or lymphoma cells.
Claim 4
Dependent Claim
16 words
The method of claim 1 wherein the carcinoma cells are breast, lung, colon or ovarian carcinomas.
References Cited (Backward Citations)
EP0169016A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-03-27 | 1992-09-26 | 1993-03-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-03-27 | 1996-09-26 | 1997-03-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-03-27 | 2000-09-26 | 2001-03-28 | $7700.00 | Window Closed / Lapsed |