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US4815474A
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Temporal trajectory analysis in brain electrical activity mapping
Assignee: Boston Children's Hospital
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Filing: 1987-04-13
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Granted: 1989-03-28
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Expires: 2007-04-13
Abstract
Abstract Pathological changes in brain electrical activity over time caused by for example growth of a lesion are detected by producing a brain electrical activity map such as a statistical probability map, and then selecting a template or mask surrounding a suspect area, summating values of the map within the template area to form an aggregate statistical feature, and then plotting the feature over a period of time, e.g. several weeks, to form a trend plot characteristic of brain electrical activity changes.
Inventors
- 👤 Frank H. Duffy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:45
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/24; A61B5/316; A61B5/369; A61B5/372
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
73 words
A method of detecting a change in brain electrical activity, comprising the steps of: choosing a template defining a selected region of a patient's brain electrical activity map, summing the values of the brain electrical activity map within the area defined by said template to form a feature, plotting said feature versus time to form a trend plot, detecting a change in said trend plot characteristic of said change in brain electrical activity.
Claim 2
Independent Claim
73 words
A method of detecting a change in brain electrical activity, comprising the steps of: choosing a template defining a selected region of a patient's brain electrical activity map, summing the values of the brain electrical activity map within the area defined by said template to form a feature, plotting said feature versus time to form a trend plot, detecting a change in said trend plot characteristic of said change in brain electrical activity.
Claim 3
Dependent Claim
18 words
The method of claim 1 wherein the change being detected is indicative of the growth of a lesion.
Claim 4
Dependent Claim
41 words
The method of claim 2 wherein said step of choosing comprises selecting a plurality of concentric, ring-shaped templates which surround the area of said brain electrical activity map corresponding to said lesion, and wherein trend plots for each template are prepared.
Claim 5
Dependent Claim
33 words
The method of claim 2 wherein said step of choosing comprises selecting a template in the shape of a ring surrounding the area of the brain electrical activity map corresponding to said lesion.
Claim 6
Dependent Claim
33 words
The method of claim 4 wherein the difference between the inner and outer radius of said ring is between 1/4 and 3/4 the diameter of the abnormality if reduced to roughly circular size.
Claim 7
Dependent Claim
55 words
The method of claim 4 wherein said step of plotting comprises plotting trend plots for at least two templates, one corresponding to the area of the lesion and another to a ring surrounding the lesion, so that it can be determined whether the lesion is growing in the same area or expanding outside that area.
Claim 8
Dependent Claim
32 words
The method of claim 1 wherein said step of choosing comprises choosing a template in the area of the brain electrical activity map that relates to a suspected location of a lesion.
Claim 9
Dependent Claim
52 words
The method of claim 1 wherein said step of choosing comprises determining the location of one or more portions of said brain electrical activity map that varies from a predetermined normal brain electrical activity map and choosing the location of said template based on the location of said one or more portions.
Claim 10
Dependent Claim
23 words
The method of claim 8 wherein a t-statistic statistical probability map is prepared to establish the location of said one or more portions.
Claim 11
Dependent Claim
34 words
The method of claim 8 wherein a procedure for establishing the location of said one or more portions utilizes one of the following: slope of regression line, significance of regression line, or correlation coefficient.
Claim 12
Dependent Claim
19 words
The method of claim 8 wherein said template is a ring surrounding one of said one or more portions.
Claim 13
Dependent Claim
33 words
The method of claim 11 wherein the difference between the inner and outer radius of said ring is between 1/4 and 3/4 the diameter of the abnormality if reduced to roughly circular size.
Claim 14
Dependent Claim
18 words
The method of claim 1 wherein said detected change in the trend plot is a change in slope.
Claim 15
Dependent Claim
18 words
The method of claim 1 wherein said detected change in the trend plot is exceeding a predetermined threshold.
Claim 16
Dependent Claim
21 words
The method of claim 1 wherein a brain electrical activity map derived from EEG data is used to determine said feature.
Claim 17
Dependent Claim
21 words
The method of claim 1 wherein a brain electrical activity map derived from EP data is used to determine said feature.
Claim 18
Dependent Claim
27 words
The method of claim 1 wherein said step of choosing comprises selecting a plurality of concentric ring-shaped templates, and wherein trend plots for each template are prepared.
Claim 19
Dependent Claim
25 words
The method of claim 1 wherein said template is chosen to correspond to one of the quadrants of the head or to known anatomical boundaries.
Claim 20
Dependent Claim
48 words
The method of claim 1 wherein said step of choosing comprises studying a patient's brain electrical activity maps over a period of time to determine the location of portions of said maps that are changing over time, and selecting the template based on the location of said portions.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-03-27 | 1992-09-26 | 1993-03-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-03-27 | 1996-09-26 | 1997-03-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-03-27 | 2000-09-26 | 2001-03-28 | $7700.00 | Window Closed / Lapsed |