Rebeccamycin derivative containing pharmaceutical composition

Claim 1

A pharmaceutical composition comprising a tumor growth-inhibiting amount of about 0.5-90% by weight based on total weight of composition of at least one compound selected from the group of compounds having the formulas ##STR6## wherein n is an integer from 1 to 6; R 1 and R 2 , independently, are selected from hydrogen, unsubstituted and substituted C 1 -C 6 alkyl, aralkyl having 1 to 3 carbons in the alkyl moeity and unsubstituted phenyl or phenyl substituted with 1 to 3 alkyl, alkoxy, hydroxy, halo, carboxyl, alkoxycarbonyl and amino and mon- and di-lower-alkylamino groups in the aryl moiety, and aryl selected from unsubstituted phenyl and phenyl substituted with 1 to 3 alkyl, alkoxy, hydroxy, halo, amino, mono- and dialkylamino, nitro, carboxyl, alkoxycarbonyl and cyano groups provided that both R 1 and R 2 are not each aryl and, when taken together, R 1 and R 2 may be selected from --(CH 2 ) 4 -- and (CH 2 ) 2 --R 3 --(CH 2 ) 2 -- to form a 5- or 6-membered ring together with the N-atom wherein R 3 is selected from CH 2 , NH, O and S; X is selected from H, F, Cl, Br, C 1 -C 3 alkyl, OH, carboxyl, alkoxycarbonyl and alkoxy wherein the alkyl moiety is C 1 -C 3 alkyl, and benzyloxy; and R 4 is selected from H and CH 3 ; and pharmaceutically acceptable acid addition and base salts thereof, and a pharmaceutically acceptable carrier.