Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
141 words
A diagnostic preparation for use in investigation of the transport function of a female fallopian tube, comprising a suspension of particles in a vehicle, wherein said particles (1) have a spherical shape with a diameter from about 10 to about 600 um, (2) are formed from a soft hydrophilic gel based on a crosslinked, nontoxic, biodegradable polymer selected from (a) polysaccharides which contain glucose bound predominantly throughb 1,4 glycoside bonds, (b) polyamino acids derived from glutamic acid or aspartic acid, and (c) polypeptides which are soluble derivatives of collagen or elastin, and (3) retain their shape and size in the environment of a peritoneal cavity and a uterotubal tract for at least 80 hours and subsequently degrade to nontoxic products within 5 to 60 days in such an environment, and said vehicle is a physiologically acceptable vehicle suitable for parenteral injection.
Claim 2
Dependent Claim
141 words
A diagnostic preparation for use in investigation of the transport function of a female fallopian tube, comprising a suspension of particles in a vehicle, wherein said particles (1) have a spherical shape with a diameter from about 10 to about 600 um, (2) are formed from a soft hydrophilic gel based on a crosslinked, nontoxic, biodegradable polymer selected from (a) polysaccharides which contain glucose bound predominantly throughb 1,4 glycoside bonds, (b) polyamino acids derived from glutamic acid or aspartic acid, and (c) polypeptides which are soluble derivatives of collagen or elastin, and (3) retain their shape and size in the environment of a peritoneal cavity and a uterotubal tract for at least 80 hours and subsequently degrade to nontoxic products within 5 to 60 days in such an environment, and said vehicle is a physiologically acceptable vehicle suitable for parenteral injection.
Claim 3
Dependent Claim
12 words
The preparation of claim 1 wherein the biodegradable polymer is a polysaccharide.
Claim 4
Dependent Claim
16 words
The preparation of claim 1 wherein the biodegradable polymer is a poly(amino acid) or a polypeptide.
Claim 5
Dependent Claim
23 words
The preparation of claim 1 wherein the particles have a chromophoric or fluorophoric compound convalently bound to the polymeric compound of the particles.
Claim 6
Dependent Claim
33 words
The preparation of claim 1 wherein an additional substance which influrences a biological property is bonded to the particles, said substance being selected from the group consisting of poly(amino acids), polypeptides, and hormones.
Claim 7
Independent Claim
142 words
A method for the preparation of a diagnostic preparation for use in investigation of the transport function of a female fallopian tube, comprising dispersing, in a nonpolar, water-immiscible solvent, an aqueous suspension of a nontoxic, biodegradable polymer selected from (a) polysaccharides which contain glucose bound predominantly throughb 1,4 glycoside bonds, (b) polyamino acids derived from glutamic acid or aspartic acid, and (c) polypeptids which are soluble derivatives of collagen or elastin, said nonpolar, water-immiscible solvent containing from 0.1 to 10 wt. % of a polymeric suspension stabilizer, said dispersing being with mixing sufficient to form polymeric spherical particles having diameters from 10 to 600 um, transforming the particles into a gel state by contacting the same with a bifunctional crosslinking agent, washing the same with an alkaline aqueous solution, and dispersing the particles in a vehicle which is suitable for parenteral administration.
Claim 8
Independent Claim
142 words
A method for the preparation of a diagnostic preparation for use in investigation of the transport function of a female fallopian tube, comprising dispersing, in a nonpolar, water-immiscible solvent, an aqueous suspension of a nontoxic, biodegradable polymer selected from (a) polysaccharides which contain glucose bound predominantly throughb 1,4 glycoside bonds, (b) polyamino acids derived from glutamic acid or aspartic acid, and (c) polypeptids which are soluble derivatives of collagen or elastin, said nonpolar, water-immiscible solvent containing from 0.1 to 10 wt. % of a polymeric suspension stabilizer, said dispersing being with mixing sufficient to form polymeric spherical particles having diameters from 10 to 600 um, transforming the particles into a gel state by contacting the same with a bifunctional crosslinking agent, washing the same with an alkaline aqueous solution, and dispersing the particles in a vehicle which is suitable for parenteral administration.
Claim 9
Dependent Claim
23 words
The method of claim 6 wherein the suspension stabilizer contains 80-100 mol. % of gamma-alkyl-L-glutamate units and 0-20 mol. % of L-glutamic acid.
Claim 10
Dependent Claim
20 words
The method of claim 6 further comprising the step of chemically activating the particles for binding with biologically active peptides.
Claim 11
Dependent Claim
33 words
The method of claim 6 wherein the aqueous suspension also contains an aminoacyl derivative of a fluorochrome, a dispersed pigment, or magnetic particles, in an amount from 0 to about 10 wt. %.