US4801459A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Technique for drug and chemical delivery
Assignee: Individual
•
Filing: 1986-08-05
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Granted: 1989-01-31
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Expires: 2006-08-05
Abstract
Abstract A technique for rapidly delivering drugs and/or chemicals to a specific area of the body by subjecting a liposome encapsulated drug and/or chemical to nonionizing electromagnetic fields. By subjecting the liposome to such fields in the range of 26-2,450 MHz drug/chemical release occurs in a rapid fashion and at temperatures that the liposomes are normally not leaky. This is a non-thermal effect of the field on the liposome that is not related to heating. Consequently, localized release of drug/chemicals can be effected without subjecting the diseased tissue to adverse heating. In addition, drug/chemical release due to electromagnetic-field treatment of liposomes is enhanced by serum and/or oxygen.
Inventors
- 👤 Robert P. Liburdy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:38
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K41/00; A61K41/0028; A61N; A61N1/00; A61N1/40; A61N5/00; A61N5/02; Y; Y10; Y10S; Y10S436/00; Y10S436/829; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
105 words
A method of delivering a chemical agent to a preselected area of a body, comprising the steps of: (a) encapsulating said chemical agent within a liposome, said liposome having a predetermined phase transition temperature at which said liposome is capable of releasing said chemical agent; (b) injecting said liposome into the blood stream of said body; and (c) subjecting said preselected area of said body to nonionizing electromagnetic fields without heating said preselected area of said body to said predetermined phase transition temperature in order to release said chemical agent from said liposome by nonthermal means at a temperature below said predetermined phase transition temperature.
Claim 2
Independent Claim
105 words
A method of delivering a chemical agent to a preselected area of a body, comprising the steps of: (a) encapsulating said chemical agent within a liposome, said liposome having a predetermined phase transition temperature at which said liposome is capable of releasing said chemical agent; (b) injecting said liposome into the blood stream of said body; and (c) subjecting said preselected area of said body to nonionizing electromagnetic fields without heating said preselected area of said body to said predetermined phase transition temperature in order to release said chemical agent from said liposome by nonthermal means at a temperature below said predetermined phase transition temperature.
Claim 3
Dependent Claim
39 words
A method of delivering a chemical agent to a preselected area of a body as defined in claim 1 further comprising the step of ensuring that said liposome is impermeable prior to subjecting said liposome to said electromagnetic fields.
Claim 4
Dependent Claim
30 words
A method of delivering a chemical agent to a preselected area of a body as defined in claim 2 wherein said electromagnetic fields are in the range of 26-2450 MHz.
Claim 5
Dependent Claim
58 words
A method of delivering a chemical agent to a preselected area of a body as defined in claim 3 wherein said preselected area of said body is subjected to said electromagnetic fields for periods of time as short as one second and at a power of approximately 60 mW/gram of tissue at said preselected area of said body.
Claim 6
Dependent Claim
26 words
A method of delivering a chemical agent to a preselected area of a body as defined in claim 4 wherein said liposome is a unilamellar vesicle.
Claim 7
Dependent Claim
39 words
A method of delivering a chemical agent to a preselected area of a body as defined in claim 5 wherein said unilamellar vesicle is made up of 4:1 weight combination of dipalmitoylphosphatidylcholine and dipalmitoylphosphatidylglycerol prepared in a physiological buffer.
Claim 8
Dependent Claim
38 words
A method of delivering a chemical agent to a preselected area of a body as defined in claim 1 wherein said release of said chemical agent is enhanced by injecting serum into said preselected area of said body.
Claim 9
Dependent Claim
38 words
A method of delivering a chemical agent to a preselected area of a body as defined in claim 1 wherein said release of said chemical agent is enhanced by introducing oxygen into said preselected area of said body.
Claim 10
Dependent Claim
38 words
A method of delivering a chemical agent to a preselected area of said body as defined in claim 8 wherein said release of said chemical agent is enhanced by injecting serum into said preselected area of said body.
Claim 11
Independent Claim
101 words
A method of delivering a chemical agent to a preselected area of a body, comprising the steps of: (a) encapsulating said chemical agent within a liposome, said liposome having a predetermined phase transition temperature at which said liposome is capable of releasing said chemical agent; (b) injecting said liposome into a preselected tissue of said body; and (c) subjecting said preselected tissue of said body to nonionizing electromagnetic fields without heating said tissue to said predetermined phase transition temperature in order to release said chemical agent from said liposome by nonthermal means at a temperature below said predetermined phase transition temperature.
Claim 12
Independent Claim
101 words
A method of delivering a chemical agent to a preselected area of a body, comprising the steps of: (a) encapsulating said chemical agent within a liposome, said liposome having a predetermined phase transition temperature at which said liposome is capable of releasing said chemical agent; (b) injecting said liposome into a preselected tissue of said body; and (c) subjecting said preselected tissue of said body to nonionizing electromagnetic fields without heating said tissue to said predetermined phase transition temperature in order to release said chemical agent from said liposome by nonthermal means at a temperature below said predetermined phase transition temperature.
Claim 13
Dependent Claim
39 words
A method of delivering a chemical agent to a preselected area of said body as defined in claim 10 further comprising the step of ensuring that said liposome is impermeable prior to subjecting said liposome to said electromagnetic fields.
Claim 14
Dependent Claim
30 words
A method of delivering a chemical agent to a preselected area of a body as defined in claim 11 wherein said electromagnetic fields are in the range of 26≧2450 MHz.
Claim 15
Dependent Claim
58 words
A method of delivering a chemical agent to a preselected area of a body as defined in claim 12 wherein said preselected area of said body is subjected to said electromagnetic fields for periods of time as short as one second and at a power of approximately 60 mW/gram of tissue at said preselected area of said body.
Claim 16
Dependent Claim
26 words
A method of delivering a chemical agent to a preselected area of said body as defined in claim 13 wherein said liposome is a unilamellar vesicle.
Claim 17
Dependent Claim
39 words
A method of delivering a chemical agent to a preselected area of a body as defined in claim 14 wherein said unilamellar vesicle is made up of 4:1 weight combination of dipalmitoylphosphatidylcholine and dipalmitoylphosphatidylglycerol prepared in a physiological buffer.
Claim 18
Dependent Claim
38 words
A method of delivering a chemical agent to a preselected area of said body as defined in claim 10 wherein said release of said chemical agent is enhanced by injecting serum into said preselected area of said body.
Claim 19
Dependent Claim
38 words
A method of delivering a chemical agent to a preselected area of said body as defined in claim 10 wherein said release of said chemical agent is enhanced by introducing oxygen into said preselected area of said body.
Claim 20
Dependent Claim
38 words
A method of delivering a chemical agent to a preselected area of said body as defined in claim 17 wherein said release of said chemical agent is enhanced by injecting serum into said preselected area of said body.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-01-31 | 1992-08-01 | 1993-01-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-01-31 | 1996-08-01 | 1997-01-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-01-31 | 2000-08-01 | 2001-01-31 | $7700.00 | Window Closed / Lapsed |