US4792598A
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US
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Poly-dicaboxylic acid anhydrides and polymeric anhydrides therefrom
Assignee: First Fidelity Bank NA New Jersey
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Filing: 1986-09-29
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Granted: 1988-12-20
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Expires: 2006-09-29
Abstract
Abstract New poly-dicarboxylic acid anhydrides, which are suitable as bio-degradable matrix materials for the controlled release of medicinal agents in humans. The anhydrides have the following formula: ##STR1## where ##STR2## where n=an integer of two or more, for the first three radicals, or one or more for the fourth.
Inventors
- 👤 Gerd Ziegast
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:40
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; C; C08; C08G; C08G67/00; C08G67/04
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
151 words
A poly-dicarboxylic acid anhydride, containing structural units of formula ##STR157## wherein A represents a direct bond or A represents (C 1-12 )alkylene in the ortho-, meta- or para-position in the phenylring, and wherein B represents B1 or B2 where b 1 is --CH 2 --CH 2 --O-- with n>2, --CH 2 --CH 2 --CH 2 --O-- or ##STR158## with n≧2, and B 2 is ##STR159## with n=1 and wherein m=1, 2, 3 or 4 and wherein R is (C 1-20 )alkyl or substituted phenyl, or wherein ##STR160## is a (co)(poly)ester group of one or more identical or different hydroxy carboxylic acid units, and D=H, CH 3 or OCH 3 in the ortho-, meta- or para-position in the phenylring, with a molecular weight of 2,000 to 140,000 and with the units of formula I in homo- or copolymeric arrangement the polymer having terminal monocarboxylic acid anhydride residues or free carboxylic acid groups.
Claim 2
Dependent Claim
151 words
A poly-dicarboxylic acid anhydride, containing structural units of formula ##STR157## wherein A represents a direct bond or A represents (C 1-12 )alkylene in the ortho-, meta- or para-position in the phenylring, and wherein B represents B1 or B2 where b 1 is --CH 2 --CH 2 --O-- with n>2, --CH 2 --CH 2 --CH 2 --O-- or ##STR158## with n≧2, and B 2 is ##STR159## with n=1 and wherein m=1, 2, 3 or 4 and wherein R is (C 1-20 )alkyl or substituted phenyl, or wherein ##STR160## is a (co)(poly)ester group of one or more identical or different hydroxy carboxylic acid units, and D=H, CH 3 or OCH 3 in the ortho-, meta- or para-position in the phenylring, with a molecular weight of 2,000 to 140,000 and with the units of formula I in homo- or copolymeric arrangement the polymer having terminal monocarboxylic acid anhydride residues or free carboxylic acid groups.
Claim 3
Dependent Claim
101 words
A poly-dicarboxylic acid anhydride according to claim 1, having a molecular weight of from 2,000 to 100,000 at least 50 mol percent of which consists of units of formula I in which A is a direct bond or (C 1-3 ) alkylene, D and B 1 are the same as in claim 1 and B 2 = ##STR161## with n=1, wherein m is 1 or 3 and R is (C 1-20 )alkyl, or the group ##STR162## which has the same significance as in claim 1, the polymer having terminal (C 1-4 ) alkylcarboxylic acid anhydride residues or free carboxylic acid groups.
Claim 4
Dependent Claim
15 words
A poly-dicarboxylic acid anhydride according to claim 1, in which A is a direct bond.
Claim 5
Dependent Claim
18 words
A poly-dicarboxylic acid anhydride according to claim 1, which consists almost entirely of structural units of formula I.
Claim 6
Dependent Claim
18 words
A poly-dicarboxylic acid anhydride according to claim 1 having a copolymeric arrangement of the units of formula I.
Claim 7
Dependent Claim
23 words
A poly-dicarboxylic acid anhydride according to claim 5, having said arrangement, which contains group B 1 as well as group B 2 .
Claim 8
Dependent Claim
20 words
A poly-dicarboxylic acid anhydride according to claim 1, B being --CH 2 CH 2 --O-- (corresponding to "B 1 ").
Claim 9
Dependent Claim
13 words
A poly-dicarboxylic acid anhydride according to claim 1, n being 3 or more.
Claim 10
Dependent Claim
16 words
A poly-dicarboxylic acid anhydride according to claim 1, B being B 2 with R=(C 1-3 )alkyl.
Claim 11
Dependent Claim
14 words
A poly-dicarboxylic acid anhydride according to claim 1, B being B 2 with m=1.
Claim 12
Dependent Claim
16 words
A poly-dicarboxylic acid anhydride according to claim 1, having terminal (C 1-3 )alkylcarboxylic acid anhydride groups.
Claim 13
Dependent Claim
19 words
A chirurgical auxiliary material of an anhydride according to claim 1 for use in a human body after operations.
Claim 14
Dependent Claim
11 words
Filament, foil or fabric of an anhydride according to claim 1.
References Cited (Backward Citations)
GB840846A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-12-20 | 1992-06-20 | 1992-12-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-12-20 | 1996-06-20 | 1996-12-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-12-20 | 2000-06-20 | 2000-12-20 | $7700.00 | Window Closed / Lapsed |