US4786277A
Expired / Lapsed
US
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Electrodes, electrode assemblies, methods, and systems for tissue stimulation
Assignee: Boston University
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Filing: 1987-07-24
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Granted: 1988-11-22
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Expires: 2007-07-24
Abstract
Abstract A novel electrode and electrode assembly is provided which preferably uses alternating and direct electrical energy for transdermal delivery of pharmacologically active ligands and for stimulation of tissues in-vivo. Methods and systems are also disclosed which allow a broad range of therapeutic agents to be transmitted to tissues and organs superficially or deep within the body.
Inventors
- 👤 Whitney R. Powers
- 👤 Henry Sisun
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:09
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/0404; A61N1/0408; A61N1/0428; A61N1/0432; A61N1/0436; A61K; A61K41/00; A61N1/0448; A61N1/18; A61N1/044
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
60 words
An electrode intended for use with a source of energy comprising: a hydrophilic porous polymeric matrix which supports a confluent aqueous phase and has an initial ohmic resistance not greater than 500 ohms per square inch in the absence of electrically conductive salt solutions above 1.0% in concentration; and means for conveying energy from the source to said polymeric matrix.
Claim 2
Dependent Claim
60 words
An electrode intended for use with a source of energy comprising: a hydrophilic porous polymeric matrix which supports a confluent aqueous phase and has an initial ohmic resistance not greater than 500 ohms per square inch in the absence of electrically conductive salt solutions above 1.0% in concentration; and means for conveying energy from the source to said polymeric matrix.
Claim 3
Dependent Claim
58 words
An active electrode comprising: a source of energy; a hydrophilic porous polymeric matrix which supports a confluent aqueous phase and has an initial ohmic resistance not greater than 500 ohms per square inch in the absence of electrically conductive salt solutions above 1.0% in concentration; and means for conveying said energy from said source to said polymeric matrix.
Claim 4
Dependent Claim
58 words
An active electrode comprising: a source of energy; a hydrophilic porous polymeric matrix which supports a confluent aqueous phase and has an initial ohmic resistance not greater than 500 ohms per square inch in the absence of electrically conductive salt solutions above 1.0% in concentration; and means for conveying said energy from said source to said polymeric matrix.
Claim 5
Dependent Claim
68 words
An electrode assembly comprising: a source of energy; a plurality of electrodes, at least one of said electrodes comprising a hydrophilic, porous polymeric matrix which supports a confluent aqueous phase and has an initial ohmic resistance not greater than 500 ohms per square inch in the absence of electrically conductive salt solutions above 1.0% in concentration; and means for conveying said energy from said source to said electrodes.
Claim 6
Dependent Claim
68 words
An electrode assembly comprising: a source of energy; a plurality of electrodes, at least one of said electrodes comprising a hydrophilic, porous polymeric matrix which supports a confluent aqueous phase and has an initial ohmic resistance not greater than 500 ohms per square inch in the absence of electrically conductive salt solutions above 1.0% in concentration; and means for conveying said energy from said source to said electrodes.
Claim 7
Dependent Claim
84 words
The electrode as recited in claim 1, 2 or 3 wherein said polymeric matrix is selected from the group consisting of acrylamide polymers, acrylic acid polymers, methacrylic acid polymers, alkyds, butadienes, carboxylic polymers, cellulose containing products, epoxy products, ethylene oxide polymers and derivatives, fluoropolymers, formaldehyde products, gelatin and gelatin derivatives, inorganic products, natural gums, polyamides, polyimides, polyesters, polyethylene glycol polymers, polyethylamine and derivative products, polysiloxane and derivative products, polyurethane products, polyvinyl alcohol and related products, polyvinyl pyrrolidone and related products, starch and starch derivatives.
Claim 8
Dependent Claim
36 words
The electrode as recited in claim 1, 2 or 3 wherein said confluent aqueous phase of said polymeric matrix includes at least one selected from the group consisting of inorganic salts, buffers, and surface active agents.
Claim 9
Dependent Claim
32 words
The electrode as recited in claim 2 or 3 wherein said energy source in selected from the group consisting of electrical energy, laser light energy, ultrasound energy, microwave energy, and magnetic energy.
Claim 10
Dependent Claim
62 words
An active electrode comprising: a source of sinusoidal electrical energy; a hydrophilic, porous polymeric matrix which supports a confluent aqueous phase and has an initial ohmic resistance not greater than 500 ohms per square inch in the absence of electrically conductive salt solutions above 1.0% in concentration; and means for conveying said sinusoidal electrical energy from said source to said polymeric matrix.
Claim 11
Dependent Claim
62 words
An active electrode comprising: a source of sinusoidal electrical energy; a hydrophilic, porous polymeric matrix which supports a confluent aqueous phase and has an initial ohmic resistance not greater than 500 ohms per square inch in the absence of electrically conductive salt solutions above 1.0% in concentration; and means for conveying said sinusoidal electrical energy from said source to said polymeric matrix.
Claim 12
Dependent Claim
61 words
An active electrode comprising: a source of galvanic electrical energy; a hydrophilic, porous polymeric matrix which supports a confluent aqueous phase and has an initial ohmic resistance not greater than 500 ohms per square inch in the absence of electrically conductive salt solutions above 1.0% in concentration; and means for conveying galvanic electrical energy from said source to said polymeric matrix.
Claim 13
Dependent Claim
61 words
An active electrode comprising: a source of galvanic electrical energy; a hydrophilic, porous polymeric matrix which supports a confluent aqueous phase and has an initial ohmic resistance not greater than 500 ohms per square inch in the absence of electrically conductive salt solutions above 1.0% in concentration; and means for conveying galvanic electrical energy from said source to said polymeric matrix.
Claim 14
Dependent Claim
69 words
An electrode assembly comprising: a source of electrical energy; a plurality of electrodes, at least one of said electrodes comprising a hydrophilic, porous polymeric matrix which supports a confluent aqueous phase and has an initial ohmic resistance not greater than 500 ohms per square inch in the absence of electrically conductive salt solutions above 1.0% in concentration; and means for conveying said energy from said source to said electrodes.
Claim 15
Dependent Claim
69 words
An electrode assembly comprising: a source of electrical energy; a plurality of electrodes, at least one of said electrodes comprising a hydrophilic, porous polymeric matrix which supports a confluent aqueous phase and has an initial ohmic resistance not greater than 500 ohms per square inch in the absence of electrically conductive salt solutions above 1.0% in concentration; and means for conveying said energy from said source to said electrodes.
Claim 16
Dependent Claim
20 words
The electrode as recited in claim 7, 8 or 9 wherein said polymeric matrix further comprises a pharmacologically active ligand.
Claim 17
Dependent Claim
83 words
The electrode as recited in claim 7, 8 or 9 wherein said polymeric matrix is selected from the group consisting of acrylamide polymers, acrylic acid polymers, methacrylic acid polymers, alkyds, butadienes, carboxylic polymers, cellulose products, epoxy products, ethylene oxide polymers and derivatives, fluoropolymers, formaldehyde products gelatin and gelatin derivative products, inorganic products, natural gums, polyamides, polyimides, polyesters, polyethylene glycols, polyethylene amine and related products, polysiloxanes and related products, polyurethane products, polyvinyl alcohols and derivatives, polyvinyl pyrrolodine and derivative products, starch and starch derivatives.
Claim 18
Dependent Claim
17 words
The electrode as recited in claim 7, 8 or 9 wherein said polymeric matrix comprises hydroxyethyl methacrylate.
Claim 19
Dependent Claim
17 words
The electrode as recited in claim 7, 8 or 9 wherein said polymeric matrix comprises N-vinyl pyrrolidone.
Claim 20
Dependent Claim
26 words
The electrode assembly as recited in claim 9 wherein said electrical energy source is selected from the group consisting of sinusoidal and galvanic electrical energy sources.
Claim 21
Independent Claim
105 words
A method for electrical stimulation of the tissues of a subject comprising the steps of: preparing an electrode assembly comprising a source of electrical energy, a plurality of electrodes, in which at least one of said electrodes comprises a hydrophilic, porous polymeric matrix which supports a confluent aqueous phase and has an initial ohmic resistance not greater than 500 ohms per square inch in the absence of electrically conductive salt solutions above 1.0% in concentration, and means for conveying electrical energy from said source to said polymeric matrix; placing said electrode assembly onto the tissue of the subject; and conveying electrical energy to said electrodes.
Claim 22
Independent Claim
105 words
A method for electrical stimulation of the tissues of a subject comprising the steps of: preparing an electrode assembly comprising a source of electrical energy, a plurality of electrodes, in which at least one of said electrodes comprises a hydrophilic, porous polymeric matrix which supports a confluent aqueous phase and has an initial ohmic resistance not greater than 500 ohms per square inch in the absence of electrically conductive salt solutions above 1.0% in concentration, and means for conveying electrical energy from said source to said polymeric matrix; placing said electrode assembly onto the tissue of the subject; and conveying electrical energy to said electrodes.
Claim 23
Dependent Claim
30 words
The method for electrical stimulation as recited in claim 15 wherein said electrical energy source is selected from the group consisting of sinusoidal electrical energy and galvanic electrical energy source.
Claim 24
Dependent Claim
17 words
The method for electrical stimulation as recited in claim 15 wherein the tissue stimulated comprises nerve tissue.
Claim 25
Dependent Claim
17 words
The method for electrical stimulation as recited in claim 15 wherein the tissue stimulated comprises muscle tissue.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1991-11-22 | 1992-05-23 | 1992-11-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-11-22 | 1996-05-23 | 1996-11-22 | $3760.00 | Window Closed / Lapsed |
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