Patent US4673927A successfully refreshed from Google Patents.
US4784685A
Expired / Lapsed
US
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Glutathione delivery system
Assignee: Cornell Research Foundation Inc
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Filing: 1987-07-01
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Granted: 1988-11-15
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Expires: 2007-07-01
Abstract
Abstract Substantially pure alkyl monoesters of glutathione, the ester being of the glycine carboxylic acid, and use thereof to increase cellular levels of glutathione.
Inventors
- 👤 Alton Meister
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:02
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/02; C07K5/0215
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
56 words
A method for increasing cellular levels in plants of glutathione, comprising: administering a methyl and/or ethyl monoester of glutathione in substantially pure form in an amount to increase intracellular levels of glutathione, whereby said ester is transported into said cells and hydrolyzed intracellularly to glutathione, said ester being of the glycine carboxylic acid group of glutathione.
Claim 2
Independent Claim
56 words
A method for increasing cellular levels in plants of glutathione, comprising: administering a methyl and/or ethyl monoester of glutathione in substantially pure form in an amount to increase intracellular levels of glutathione, whereby said ester is transported into said cells and hydrolyzed intracellularly to glutathione, said ester being of the glycine carboxylic acid group of glutathione.
Claim 3
Dependent Claim
12 words
The method of claim 1 wherein said ester is the methyl ester.
Claim 4
Dependent Claim
12 words
The method of claim 1 wherein said ester is the ethyl ester.
Claim 5
Independent Claim
45 words
A method for increasing radiation resistance of a plant comprising: administering a substantially pure monomethyl or monoethyl ester of glutathione, with the proviso that only the glycine carboxyl group of glutathione is esterified, in a dosage sufficient to increase the radiation resistance of said plant.
Claim 6
Independent Claim
45 words
A method for increasing radiation resistance of a plant comprising: administering a substantially pure monomethyl or monoethyl ester of glutathione, with the proviso that only the glycine carboxyl group of glutathione is esterified, in a dosage sufficient to increase the radiation resistance of said plant.
Claim 7
Independent Claim
55 words
A method for safening plants by increasing their resistance to toxic effects of herbicides comprising treating crop plants or seeds thereof prior to planting with a methyl and/or ethyl monoester of glutathione, said ester being of the glycine carboxylic acid group of glutathione, to protect said crop plants against the toxic effects of a herbicide.
Claim 8
Independent Claim
55 words
A method for safening plants by increasing their resistance to toxic effects of herbicides comprising treating crop plants or seeds thereof prior to planting with a methyl and/or ethyl monoester of glutathione, said ester being of the glycine carboxylic acid group of glutathione, to protect said crop plants against the toxic effects of a herbicide.
Claim 9
Independent Claim
60 words
A method for increasing the resistance of a plant to the effects of reactive oxygen intermediates comprising: administering a substantially pure monomethyl or monoethyl ester of glutathione, with the proviso that only the glycine carboxyl group of glutathione is esterified, in a dosage sufficient to increase the resistance of said animal or plant to the effects of reactive oxygen intermediates.
Claim 10
Independent Claim
60 words
A method for increasing the resistance of a plant to the effects of reactive oxygen intermediates comprising: administering a substantially pure monomethyl or monoethyl ester of glutathione, with the proviso that only the glycine carboxyl group of glutathione is esterified, in a dosage sufficient to increase the resistance of said animal or plant to the effects of reactive oxygen intermediates.
Claim 11
Independent Claim
42 words
A method for purifying monoethyl or monomethyl ester of glutathione admixed with corresponding diester, comprising dissolving the admixture in aqueous medium, adjusting the pH to about 8.0 to 9.2 and extracting the diester using an organic solvent immiscible with the aqueous medium.
Claim 12
Independent Claim
42 words
A method for purifying monoethyl or monomethyl ester of glutathione admixed with corresponding diester, comprising dissolving the admixture in aqueous medium, adjusting the pH to about 8.0 to 9.2 and extracting the diester using an organic solvent immiscible with the aqueous medium.
Claim 13
Independent Claim
60 words
A method for increasing cellular levels in plants of glutathione, comprising: administering an alkyl (C 3 to C 10 ) monoester of glutathione in substantially pure form in an amount to increase intracellular levels of glutathione, whereby said ester is transported into said cells and hydrolyzed intracellularly to glutathione, said ester being of the glycine carboxylic acid group of glutathione.
Claim 14
Independent Claim
60 words
A method for increasing cellular levels in plants of glutathione, comprising: administering an alkyl (C 3 to C 10 ) monoester of glutathione in substantially pure form in an amount to increase intracellular levels of glutathione, whereby said ester is transported into said cells and hydrolyzed intracellularly to glutathione, said ester being of the glycine carboxylic acid group of glutathione.
Claim 15
Dependent Claim
12 words
The method of claim 8 wherein said ester is a propyl ester.
Claim 16
Dependent Claim
12 words
The method of claim 8 wherein said ester is a butyl ester.
Claim 17
Independent Claim
49 words
A method for increasing radiation resistance of a plant comprising: administering a substantially pure alkyl (C 3 to C 10 ) monoester of glutathione with the proviso that only the glycine carboxyl group of glutathione is esterified, in a dosage sufficient to increase the radiation resistance of said plant.
Claim 18
Independent Claim
49 words
A method for increasing radiation resistance of a plant comprising: administering a substantially pure alkyl (C 3 to C 10 ) monoester of glutathione with the proviso that only the glycine carboxyl group of glutathione is esterified, in a dosage sufficient to increase the radiation resistance of said plant.
Claim 19
Independent Claim
59 words
A method for safening plants by increasing their resistance to toxic effects of herbicides comprising treating crop plants or seeds thereof prior to planting with an alkyl (C 3 to C 10 ) monoester of glutathione, said ester being of the glycine carboxylic acid group of glutathione, to protect said crop plants against the toxic effects of a herbicide.
Claim 20
Independent Claim
59 words
A method for safening plants by increasing their resistance to toxic effects of herbicides comprising treating crop plants or seeds thereof prior to planting with an alkyl (C 3 to C 10 ) monoester of glutathione, said ester being of the glycine carboxylic acid group of glutathione, to protect said crop plants against the toxic effects of a herbicide.
Claim 21
Independent Claim
61 words
A method for increasing the resistance of a plant to the effects of reactive oxygen intermediates comprising: administering a substantially pure (C 3 to C 10 ) monoester of glutathione, with the proviso that only the glycine carboxyl group of glutathione is esterified, in a dosage sufficient to increase the resistance of said plant to the effects of reactive oxygen intermediates.
Claim 22
Independent Claim
61 words
A method for increasing the resistance of a plant to the effects of reactive oxygen intermediates comprising: administering a substantially pure (C 3 to C 10 ) monoester of glutathione, with the proviso that only the glycine carboxyl group of glutathione is esterified, in a dosage sufficient to increase the resistance of said plant to the effects of reactive oxygen intermediates.
Claim 23
Independent Claim
46 words
A method for purifying alkyl (C 3 to C 10 ) monoester of glutathione admixed with corresponding diester, comprising dissolving the admixture in aqueous medium, adjusting the pH to about 8.0 to 9.2 and extracting the diester using an organic solvent immiscible with the aqueous medium.
Claim 24
Independent Claim
46 words
A method for purifying alkyl (C 3 to C 10 ) monoester of glutathione admixed with corresponding diester, comprising dissolving the admixture in aqueous medium, adjusting the pH to about 8.0 to 9.2 and extracting the diester using an organic solvent immiscible with the aqueous medium.
References Cited (Backward Citations)
JPH108399A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-11-15 | 1992-05-16 | 1992-11-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-11-15 | 1996-05-16 | 1996-11-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-11-15 | 2000-05-16 | 2000-11-15 | $7700.00 | Window Closed / Lapsed |