US4780212A
Expired / Lapsed
US
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Ultrasound enchancement of membrane permeability
Assignee: Massachusetts Institute of Technology
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Filing: 1987-07-31
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Granted: 1988-10-25
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Expires: 2007-07-31
Abstract
Abstract A method for enhancing or controlling permeability of large molecular weight molecules in a membrane system wherein molecules in solution are contacted with membranes and the system is exposed to ultrasound at a selected intensity and frequency and for a specific length of time. The method may be designed to insure that only reversible changes in the membrane result from exposure to the ultrasound or to enhance the rate of degradation of the membrane and/or selectivity of passage of molecules through the membrane. The method may include selection of the membrane composition and structure, including the pore size, thickness, crystallinity and molecular arrangement. Selection of the solvent or media in which the molecules are suspended may be used to further enhance or control permeability. The media may be either an aqueous or inorganic solution with the physical and chemical properties may be selected to attenuate sound transmission or to enhance stability of the molecule permeating the membrane.
Inventors
- 👤 Joseph Kost
- 👤 Robert S. Langer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:39
CPC Classifications
B; B01; B01D; B01D61/00; B01D61/24; B01D61/243; A; A61; A61M; A61M37/00; A61M37/0092; B01D63/00; B01D63/16
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
61 words
A method comprising: controlling transport of preselected species of molecules in a solution through a membrane, by, providing a membrane containing apparatus, contacting a solution containing molecules with the membrane, exposing the membrane containing apparatus to ultrasound, and adjusting the intensity, frequency and time of exposure of the ultrasound sufficient to selectively pass said preselected species of molecules through the membrane.
Claim 2
Independent Claim
61 words
A method comprising: controlling transport of preselected species of molecules in a solution through a membrane, by, providing a membrane containing apparatus, contacting a solution containing molecules with the membrane, exposing the membrane containing apparatus to ultrasound, and adjusting the intensity, frequency and time of exposure of the ultrasound sufficient to selectively pass said preselected species of molecules through the membrane.
Claim 3
Dependent Claim
25 words
The method of claim 1 wherein the frequency and intensity of the ultrasound is limited to produce predominantly reversible changes in the molecules and membrane.
Claim 4
Dependent Claim
19 words
The method of claim 1 further comprising removing molecules interspersed within the membrane by exposing the membrane to ultrasound.
Claim 5
Dependent Claim
36 words
The method of claim 1 wherein the frequency of the ultrasound is between about 10 kHz and 20 MHz and the intensity of the ultrasound is between about 0.05 watt/cm 2 and 30 watts/cm 2 .
Claim 6
Dependent Claim
29 words
The method of claim 4 wherein the ultrasound frequency is between approximately 1 MHz and 3 MHz and the intensity is between approximately 0.05 and 3 W/cm 2 .
Claim 7
Dependent Claim
33 words
The method of claim 1 wherein the molecules are selected from the group of large molecular weight compounds consisting of proteins, cofactors, chemical compounds, nucleic acid sequences, saccharides, peptides, polymers and combinations thereof.
Claim 8
Dependent Claim
29 words
The method of claim 1 further comprising selecting a membrane composition and structure having a selective effect on the passage of the molecules in solution upon exposure to ultrasound.
Claim 9
Dependent Claim
19 words
The method of claim 7 wherein the membrane is selected to have a specific molecular weight cut off range.
Claim 10
Dependent Claim
47 words
The method of claim 7 wherein the membrane is selected from the group of organic, inorganic and biological polymer compositions consisting of polyanhydrides, ethylenevinyl acetate polymers, silicone, hydroxyethylmethacrylate, vinyl alcohol, polylactides, polyglyclolides, polycaprolactone, lactic glycolic copolymers, polyorthoesters, polyamides, agarose, carbohydrates, celluloses, polypropylene, polyethylene, polyurethanes, and combinations thereof.
Claim 11
Dependent Claim
18 words
The method of claim 1 further comprising selecting a membrane composition which degrades in response to the ultrasound.
Claim 12
Dependent Claim
30 words
The method of claim 10 further comprising selecting the frequency, intensity and time of exposure of the membrane to the ultrasound to increase the rate of degradation of the membrane.
Claim 13
Dependent Claim
23 words
The method of claim 1 further comprising altering the three dimensional structure of said molecules by selection of the solvent for the molecules.
Claim 14
Dependent Claim
21 words
The method of claim 12 further comprising selecting the solvent for the degree of attenuation of the ultrasound by the solvent.
Claim 15
Dependent Claim
23 words
The method of claim 1 wherein application of the ultrasound directly to the membrane alters the passage of the molecules through the membrane.
Claim 16
Dependent Claim
21 words
The method of claim 1 wherein application of the ultrasound to the solution alters passage of the molecules through the membrane.
Claim 17
Dependent Claim
15 words
The method of claim 1 wherein the passage of molecules through the membrane is enhanced.
Claim 18
Independent Claim
70 words
A method for enhancing membrane dialysis comprising controlling transport of preselected species of molecules in a solution through a membrane, by, exposing a kidney dialysis apparatus to ultrasound at a frequency between about 10 KHz and 20 MHz and at an intensity of between about 0.05 and 30 W/cm 2 , wherein the frequency and intensity of the ultrasound is limited to avoid irreversible damage to the membrane and blood.
Claim 19
Independent Claim
70 words
A method for enhancing membrane dialysis comprising controlling transport of preselected species of molecules in a solution through a membrane, by, exposing a kidney dialysis apparatus to ultrasound at a frequency between about 10 KHz and 20 MHz and at an intensity of between about 0.05 and 30 W/cm 2 , wherein the frequency and intensity of the ultrasound is limited to avoid irreversible damage to the membrane and blood.
Claim 20
Independent Claim
77 words
A method for enhancing the oxygenation of blood comprising controlling transport of preselected species of molecules in a solution through a membrane, by, exposing a solution to be oxygenated in a membrane oxygenator device to ultrasound at a frequency between about 10 KHz and 20 MHz and an intensity of between about 0.05 and 30 W/cm 2 , wherein the frequency and intensity of the ultrasound is limited to avoid irreversible damage to the membrane and solution.
Claim 21
Independent Claim
77 words
A method for enhancing the oxygenation of blood comprising controlling transport of preselected species of molecules in a solution through a membrane, by, exposing a solution to be oxygenated in a membrane oxygenator device to ultrasound at a frequency between about 10 KHz and 20 MHz and an intensity of between about 0.05 and 30 W/cm 2 , wherein the frequency and intensity of the ultrasound is limited to avoid irreversible damage to the membrane and solution.
Claim 22
Independent Claim
60 words
A method for controlling the rate of a separation process comprising controlling transport of preselected species of molecules in a solution through a membrane, by, selecting a separation system medium and exposing the molecules to be separated to ultrasound in the medium, wherein the molecules move within the medium as a function of the frequency and intensity of the ultrasound.
Claim 23
Independent Claim
60 words
A method for controlling the rate of a separation process comprising controlling transport of preselected species of molecules in a solution through a membrane, by, selecting a separation system medium and exposing the molecules to be separated to ultrasound in the medium, wherein the molecules move within the medium as a function of the frequency and intensity of the ultrasound.
Claim 24
Dependent Claim
28 words
The method of claim 19 further comprising selecting the separation mediums from the group of solid matrices consisting of agarose, sepharose, polymethacrylate, polyacrylamide, cellulose, ceramics and derivatives thereof.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1991-10-25 | 1992-04-25 | 1992-10-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-10-25 | 1996-04-25 | 1996-10-25 | $3760.00 | Window Closed / Lapsed |
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