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US4775522A Expired / Lapsed US ⏱️ 0.0 years remaining

NMR compositions for indirectly detecting a dissolved gas in an animal

Assignee: Childrens Hospital Research Foundation
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Filing: 1985-12-16
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Granted: 1988-10-04
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Expires: 2005-12-16
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Abstract

Abstract A novel and improved method to detect and/or measure indirectly at least one gas, particularly dissolved gases, of an animal employing nuclear magnetic resonance techniques (NMR). The method examines an NMR spectrum to determine chemical shift relaxation times or spin-spin couplings for an element of an animal influenced by at least one gas of the animal. Uniquely, the gas detected according to the principles of this invention may be insensitive to present NMR techniques. Further, the present invention discloses a novel method to determine and monitor gaseous physiological states of an animal. Because of the unique and advantageous non-invasive, non-destructive and non-ionizing properties, the present invention may be employed in an animal continuously and in vivo. Still further, the present invention provides for the imaging of at least one-, two-, or three-dimensional projections reconstructed from a chemical shift, relaxation times, or spin-spin couplings for an element of an animal influenced by at least one gas in the animal. Novel compounds directed to providing radio-frequency reference signals in which chemical shifts may be determined therefrom are also disclosed.

Inventors

  • 👤 Leland C. Clark, Jr.

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 13:15
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61K; A61K49/00; A61K49/06; A61K49/18; A61K49/1806; G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/46; G01R33/465; G01R33/48; G01R33/483; G01R33/485; G01R33/54; G01R33/56; G01R33/5601; Y; Y10; Y10T; Y10T436/00; Y10T436/24

Claims Analysis

Total Claims: 12
Claim 1
Independent Claim 125 words
An NMR composition suitable for introduction into an animal for detecting indirectly a dissolved gas in the animal with an NMR technique, said NMR composition comprising a compound containing a sufficient amount of an element adapted for NMR detection with an NMR technique, the element being influenced by the dissolved gas when said NMR composition is introduced into the animal, and an aqueous liquid mixed with said compound which forms said NMR composition whereby, when said NMR composition is introduced into the animal and the animal is subjected to an NMR spectrometer, a radio-frequency signal derived from the nuclear magnetic resonance of the influenced element can be detected with an NMR technique to generate an NMR parameter which is a function of the dissolved gas.
Claim 2
Dependent Claim 125 words
An NMR composition suitable for introduction into an animal for detecting indirectly a dissolved gas in the animal with an NMR technique, said NMR composition comprising a compound containing a sufficient amount of an element adapted for NMR detection with an NMR technique, the element being influenced by the dissolved gas when said NMR composition is introduced into the animal, and an aqueous liquid mixed with said compound which forms said NMR composition whereby, when said NMR composition is introduced into the animal and the animal is subjected to an NMR spectrometer, a radio-frequency signal derived from the nuclear magnetic resonance of the influenced element can be detected with an NMR technique to generate an NMR parameter which is a function of the dissolved gas.
Claim 3
Dependent Claim 20 words
An NMR composition of claim 1 wherein said compound is a perfluorocarbon or derivative thereof and the element is flourine.
Claim 4
Dependent Claim 13 words
An NMR composition of claim 2 wherein said NMR composition is an emulsion.
Claim 5
Dependent Claim 15 words
An NMR composition of claim 3 wherein said perfluorocarbon or derivative thereof is a perfluorocyclocarbon.
Claim 6
Dependent Claim 13 words
An NMR composition of claim 3 wherein said aqueous liquid includes a surfactant.
Claim 7
Dependent Claim 11 words
An NMR composition of claim 5 wherein said surfactant is XMO-10.
Claim 8
Dependent Claim 73 words
An NMR composition of claim 1 wherein said compound is selected from a group of perfluorocarbon compounds comprising perfluorodecalin, perfluoromethyldecalin, perfluoroetherpolymer (Fomblin Y/01), perfluorotrimethylbicyclononane, perfluorotributylamine (FC-47), perfluorotripropylamine, perfluoro-1-3-dimethyladamantane and perfluorotrimethylbicyclo[3.3.1]nonane (DAWN), perfluoroether (PID) [(CF 3 ) 2 CFOCF 2 (CF 2 ) 2 CF 2 OCF(CF 3 ) 2 ], perfluoroether (PIID) [(CF 3 ) 2 CFOCF 2 (CF 2 ) 6 CF 2 OCF(CF 3 ) 2 ], ##STR3## perfluorohexane and perfluorooctylbromide.
Claim 9
Dependent Claim 35 words
An NMR composition of claim 3 wherein the emulsion is a perfluorocarbon emulsion comprising a perfluorocarbon in an amount on the order of 10% V/V and a surfactant in an amount of about 3-10% V/V.
Claim 10
Dependent Claim 13 words
An NMR composition of claim 3 wherein said surfactant is a pluronic surfactant.
Claim 11
Dependent Claim 12 words
An NMR composition of claim 1 wherein said compound is a perfluorocyclocarbon.
Claim 12
Dependent Claim 11 words
An NMR composition of claim 1 wherein the element is flourine.

References Cited (Backward Citations)

US4297637A Cited
US4318043A Cited
US4361807A Cited
US4319190A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1991-10-04 1992-04-04 1992-10-04 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1995-10-04 1996-04-04 1996-10-04 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1999-10-04 2000-04-04 2000-10-04 $7700.00 Window Closed / Lapsed

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