US4772471A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Aqueous dispersions of lipid spheres and compositions containing the same
Assignee: L'Oréal SA
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Filing: 1979-12-12
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Granted: 1988-09-20
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Expires: 1999-12-12
Abstract
Abstract A dispersion in a continuous phase or spherules comprises arranged molecular layers of a non-ionic lipid compound encapsulating an aqueous phase wherein the non-ionic lipid compound has a lipophile group/hydrophile group ratio such that the non-ionic lipid compound swells in the aqueous phase to be encapsulated therein so as to form a lamellar phase. The hydrophile group of the non-ionic compound is selected from the group consisting of polyoxyethylene groups, polyglycerol groups and esters of polyols. The spherules have a diameter between 1,000 ANGSTROM and 50,000 ANGSTROM .
Inventors
- 👤 Guy Vanlerberghe
- 👤 Rose-Marie Handjani
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:55
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K8/00; A61K8/02; A61K8/14; A61K9/1271; A61K9/1272; A61Q; A61Q17/00; A61Q17/04; A61Q19/00; A61Q19/04; C; C09; C09K; C09K23/00; C09K23/14; Y; Y10; Y10S; Y10S424/00; Y10S424/812; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984; Y10T428/2985
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
87 words
A dispersion in a continuous phase of spherules comprising arranged molecular layers of a non-ionic lipid compound encapsulating an aqueous phase wherein the non-ionic lipid compound has a lipophile group/hydrophile group ratio such that the non-ionic lipid compound swells in the aqueous phase to be encapsulated therein so as to form a lamellar phase, the hydrophile group of said nonionic compound being selected from the group consisting of polyoxyethylene groups, polyglycerol groups and other polyol groups, said spherules having a diameter between 1,000 Å and 50,000 Å.
Claim 2
Dependent Claim
87 words
A dispersion in a continuous phase of spherules comprising arranged molecular layers of a non-ionic lipid compound encapsulating an aqueous phase wherein the non-ionic lipid compound has a lipophile group/hydrophile group ratio such that the non-ionic lipid compound swells in the aqueous phase to be encapsulated therein so as to form a lamellar phase, the hydrophile group of said nonionic compound being selected from the group consisting of polyoxyethylene groups, polyglycerol groups and other polyol groups, said spherules having a diameter between 1,000 Å and 50,000 Å.
Claim 3
Dependent Claim
98 words
The dispersion of claim 1 wherein the non-ionic lipid compound is selected from the group consisting of (1) linear or branched polyglycerol ethers having, respectively, the formulas R--OCH 2 CHOHCH 2 -- n OH and ##STR21## wherein n is a whole number between 1 and 6, R is selected from the group consisting of a linear or branched, saturated or unsaturated aliphatic chain having 16 to 20 carbon atoms, the hydrocarbon residue of lanolin alcohols and the 2-hydroxy alkyl residue of long chain α-diols, (2) polyoxyethylenated fatty alcohols, (3) esters of polyols, and (4) natural or synthetic glycolipids.
Claim 4
Dependent Claim
76 words
The dispersion of claim 1 wherein said non-ionic lipid is combined with an additive selected from the group consisting of a long chain alcohol or diol; a sterol; a long chain amine or the quaternary ammonium derivative thereof; a dihydroxyalkylamine; a polyoxyethylenated fatty amine; an ester of a long chain amino alcohol, a salt thereof or a quaternary ammonium derivative thereof; a phosphoric ester of a fatty alcohol; an alkyl sulfate; a polypeptide and a protein.
Claim 5
Dependent Claim
13 words
The dispersion of claim 1 wherein said continuous phase is an aqueous phase.
Claim 6
Dependent Claim
21 words
The dispersion of claim 1 wherein said aqueous phase encapsulated in said spherules is an aqueous solution of an active compound.
Claim 7
Dependent Claim
24 words
The dispersion of claim 1 wherein said aqueous phase encapsulated in said spherules is iso-osmotic relative to the said continuous phase of said dispersion.
Claim 8
Dependent Claim
23 words
The dispersion of claim 1 wherein said aqueous phase encapsulated in said spherules is an aqueous solution of a component exhibiting cosmetic activity.
Claim 9
Dependent Claim
24 words
The dispersion of claim 1 wherein said aqueous phase encapsulated in said spherules is an aqueous solution of at least one pharmaceutically active substance.
Claim 10
Dependent Claim
26 words
The dispersion of claim 8 wherein said pharmaceutically active substance is selected from the group consisting of vitamins, hormones, enzymes, vaccines, anti-inflammatory agents, antibiotics and bactericides.
Claim 11
Dependent Claim
23 words
The dispersion of claim 1 wherein said aqueous phase encapsulated in said spherules is an aqueous solution of at least one alimentary substance.
Claim 12
Dependent Claim
24 words
The dispersion of claim 1 wherein the weight of the spherules relative to the weight of the continuous phase is between 0.01 to 0.5.
References Cited (Backward Citations)
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Cited
FR1477048A
Cited
US3686701A
Cited
US3630920A
Cited
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Cited
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-09-20 | 1992-03-21 | 1992-09-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-09-20 | 1996-03-21 | 1996-09-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-09-20 | 2000-03-21 | 2000-09-20 | $7700.00 | Window Closed / Lapsed |