US4770664A
Expired / Lapsed
US
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Multilayered prosthesis material and a method of producing same
Assignee: Mendinvent SA
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Filing: 1985-01-17
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Granted: 1988-09-13
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Expires: 2005-01-17
Abstract
Abstract A method producing a multilayered prosthesis material for use with a living body, said material showing mechanical compliance vis-a-vis soft body tissue and possessing biocompatibility. The method comprising the steps: (a) preparing a copolymer solution using a solvent; (b) coating a substrate with a uniform thickness of said solution; (c) precipitating the initial coating resulting from step (b) to form a physically stable structure having pores substantially uniformly distributed therein by treating the coating with a precipitating solution which is miscible in said solvent but functioning as a precipitating non-solvent with respect to the copolymer; and (d) repeating steps (a)-(c), as required to form the multilayered material, characterized by preparing in step (a) a solution containing less than 5% by weight of polymer. Also disclosed is a multilayered prosthesis material possessing biocompatibility and showing mechanical compliance vis-a-vis soft body tissue, comprising several porous layers of block copolyurethane interconnected by linking fibers integral with the respective adjacent layers.
Inventors
- 👤 Sylwester Gogolewski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:05
CPC Classifications
C; C08; C08J; C08J3/00; C08J3/02; C08J3/09; C08J3/091; A; A61; A61F; A61F13/00; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/26; A61L15/42; A61L15/425; A61L15/64; A61L27/00; A61L27/28; A61L27/34; A61L27/50; A61L27/56; A61L27/58; B; B29; B29C; B29C67/00; B29C67/02; B29C67/06; A61F2013/00089; A61F2013/00165; A61F2013/00217; A61F2013/00221; A61F13/15; A61F13/15577; A61F2013/15821; A61F13/51; A61F13/514; A61F13/51401; A61F2013/51409; A61F2013/51411; C08J2375/00; C08J2375/04; Y; Y10; Y10S; Y10S623/00; Y10S623/915
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
121 words
A method of producing a multilayered prosthesis material for use with a living body, said material showing mechanical compliance vis-a-vis soft body tissue and possessing biocompatibility, said method comprising the steps: (a) preparing a polymer solution using a solvent wherein said polymer solution contains less than 5% by weight of polymer; (b) coating a substrate with a uniform thickness of said solution; (c) precipitating the intial coating resulting from step (b) to form a physically stable structure having pores substantially uniformly distributed therein by treating the coating with a precipitating solution which is miscible in said solvent but functioning as a precipitating non-solvent with respect to the polymer; and (d) repeating steps (a)-(c), as required , to form a multilayered material.
Claim 2
Independent Claim
121 words
A method of producing a multilayered prosthesis material for use with a living body, said material showing mechanical compliance vis-a-vis soft body tissue and possessing biocompatibility, said method comprising the steps: (a) preparing a polymer solution using a solvent wherein said polymer solution contains less than 5% by weight of polymer; (b) coating a substrate with a uniform thickness of said solution; (c) precipitating the intial coating resulting from step (b) to form a physically stable structure having pores substantially uniformly distributed therein by treating the coating with a precipitating solution which is miscible in said solvent but functioning as a precipitating non-solvent with respect to the polymer; and (d) repeating steps (a)-(c), as required , to form a multilayered material.
Claim 3
Dependent Claim
21 words
The method of claim 1, wherein the solution prepared in step (a) contains less than about 3% by weight of polymer.
Claim 4
Dependent Claim
25 words
The method of claim 1, wherein at least a portion of the solvent is left in each preceding layer when the subsequent layer is applied.
Claim 5
Dependent Claim
73 words
The method of claim 3, wherein the precipitating solution comprises as a major constituent, a fluid which is miscible in said solvent but functions as a precipitating non-solvent with respect to the polymer, and further comprises as a minor constituent, a solvent for the polymer, whereby when repeating steps (a)-(c), due to the presence in the precipitating solution of solvent, mechanical binding will be obtained between said initial coating and the subsequent one.
Claim 6
Dependent Claim
35 words
The method of claim 3, wherein the treatment of the coating with the precipitating solution is interrupted so that a portion of the solvent is left in the coating when the subsequent layer is applied.
Claim 7
Dependent Claim
13 words
A method according to claim 1, wherein said polymer solution contains a copolyurethane.
Claim 8
Dependent Claim
13 words
A method according to claim 6, wherein the polymer is a segmented copolyurethane.
Claim 9
Dependent Claim
22 words
A method according to claim 1, wherein the solvent is selected from the group consisting of tetrahydrofurane, amide solvents and sulfoxide solvents.
Claim 10
Dependent Claim
16 words
A method according to claim 1, wherein the non-solvent is selected from water and lower alkanols.
Claim 11
Dependent Claim
32 words
The method of claim 1, wherein by varying the concentration of polymer in the solution of step (a) a multilayered material is produced wherein the different layers have different average pore sizes.
Claim 12
Dependent Claim
21 words
The method of claim 2, wherein the solution prepared in step (a) contains less than about 2% by weight of polymer.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1991-09-13 | 1992-03-14 | 1992-09-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-09-13 | 1996-03-14 | 1996-09-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-09-13 | 2000-03-14 | 2000-09-13 | $7700.00 | Window Closed / Lapsed |