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US4758596A
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Method for therapeutic use of methyl tertiary-butyl ether
Assignee: RESEARCH Corp A NY NOT-FOR-PROFIT CORP
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Filing: 1984-09-11
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Granted: 1988-07-19
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Expires: 2004-09-11
Abstract
Abstract Method for dissolving cholesterol calculus in vitro or in vivo comprising contacting the cholesterol calculus with methyl tertiary-butyl ether.
Inventors
- 👤 Johnson L. Thistle
- 👤 Mark J. Allen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:38
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/075; A61K31/08; A61B; A61B17/00; A61B17/22; A61B2017/22082; A61B2017/22084
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
14 words
A method for dissolving cholesterol calculus comprising contacting the calculus with methyl tertiary-butyl ether.
Claim 2
Independent Claim
14 words
A method for dissolving cholesterol calculus comprising contacting the calculus with methyl tertiary-butyl ether.
Claim 3
Dependent Claim
20 words
The method of claim 1 wherein the cholesterol calculus of a patient is contacted with methyl tertiary-butyl ether in vivo.
Claim 4
Dependent Claim
26 words
The method of claim 2 wherein the cholesterol calculus is selected from the group consisting of biliary duct stones, gallstones in the gallbladder and cholesterol plaque.
Claim 5
Dependent Claim
15 words
The method of claim 3 wherein the cholesterol calculus is a gallstone in the gallbladder.
Claim 6
Dependent Claim
22 words
The method of claim 1 wherein the cholesterol calculus is contacted with methyl tertiary-butyl ether in the biliary tract of the patient.
Claim 7
Dependent Claim
17 words
The method of claim 3 wherein the cholesterol calculus contacted with methyl tertiary-butyl ether is cholesterol plaque.
Claim 8
Dependent Claim
31 words
The method of claim 1 wherein in vivo agitation or stirring and aspiration of bile is utilized to facilitate distribution of the methyl tertiary-butyl ether and dissolving of the cholesterol calculus.
Claim 9
Independent Claim
20 words
A method for in vivo dissolving cholesterol calculus in a human patient comprising contacting the calculus with methyl tertiary-butyl ether.
Claim 10
Independent Claim
20 words
A method for in vivo dissolving cholesterol calculus in a human patient comprising contacting the calculus with methyl tertiary-butyl ether.
Claim 11
Dependent Claim
31 words
The method of claim 8 wherein in vivo agitation or stirring and removal of bile is utilized to facilitate distribution of the methyl tertiary-butyl ether and dissolving of the cholesterol calculus.
Claim 12
Dependent Claim
26 words
The method of claim 8 wherein the cholesterol calculus is selected from the group consisting of biliary duct stones, gallstones in the gallbladder and cholesterol plaque.
Claim 13
Dependent Claim
15 words
The method of claim 10 wherein the cholesterol calculus is a gallstone in the gallbladder.
Claim 14
Dependent Claim
13 words
The method of claim 1 wherein the cholesterol calculus is biliary duct stones.
Claim 15
Dependent Claim
12 words
The method of claim 1 wherein the cholesterol calculus is cholesterol plaque.
Claim 16
Dependent Claim
21 words
The method of claim 9 wherein bile is continuously or intermittently aspirated from the bile duct or gallbladder and not reinfused.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-07-19 | 1992-01-18 | 1992-07-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-07-19 | 1996-01-18 | 1996-07-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-07-19 | 2000-01-18 | 2000-07-19 | $7700.00 | Window Closed / Lapsed |