US4755167A — In vivo method for distribution and stirring of t…

Claim 1

Independent Claim 95 words

A method for distributing a therapeutic agent in a localized area of a patients body comprising oscillatingly introducing effective amounts of said therapeutic agent to said localized area with an oscillating liquid by alternately injecting and aspirating effective amounts of said oscillating liquid so as to first distribute by agitation said therapeutic agent in said localized area and then remove said therapeutic agent therefrom said therapeutic agent being either a hydrophobic solvating agent designed to dissolve undesirable matter residing in said localized area or a drug designed to have medicating effect in said localized area.

Claim 2

Independent Claim 95 words

A method for distributing a therapeutic agent in a localized area of a patients body comprising oscillatingly introducing effective amounts of said therapeutic agent to said localized area with an oscillating liquid by alternately injecting and aspirating effective amounts of said oscillating liquid so as to first distribute by agitation said therapeutic agent in said localized area and then remove said therapeutic agent therefrom said therapeutic agent being either a hydrophobic solvating agent designed to dissolve undesirable matter residing in said localized area or a drug designed to have medicating effect in said localized area.

Claim 3

Dependent Claim 13 words

The method of claim 1 wherein the oscillating liquid comprises the therapeutic agent.

Claim 4

Dependent Claim 20 words

The method of claim 1 wherein the therapeutic agent is introduced to the localized area separately from the oscillating liquid.

Claim 5

Dependent Claim 19 words

The method of claim 1 wherein the oscillating liquid is introduced by means comprising a combined aspirating injecting pump.

Claim 6

Dependent Claim 25 words

The method of claim 1 wherein the liquid is injected at a faster rate and shorter period of time than the liquid is alternately aspirated.

Claim 7

Dependent Claim 35 words

The method of claim 1 wherein the oscillating liquid is maintained in a controlled volume range whereby make up liquid can be introduced to the localized area to maintain the effective amount of oscillating liquid.

Claim 8

Independent Claim 89 words

A method for distributing a liquid therapeutic dissolving agent in a localized area of a patients body to facilitate dissolving and thereby removing undesirable matter residing therein comprising oscillatingly introducing effective amounts of said therapeutic agent to said localized area by alternately injecting and aspirating said therapeutic agent along or with an oscillating liquid to and from said localized area so as to thereby distribute by agitatiion said thereapeutic agent in said localized area and contact and dissolve said undesirable matter and remove the same from said localized area.

Claim 9

Independent Claim 89 words

A method for distributing a liquid therapeutic dissolving agent in a localized area of a patients body to facilitate dissolving and thereby removing undesirable matter residing therein comprising oscillatingly introducing effective amounts of said therapeutic agent to said localized area by alternately injecting and aspirating said therapeutic agent along or with an oscillating liquid to and from said localized area so as to thereby distribute by agitatiion said thereapeutic agent in said localized area and contact and dissolve said undesirable matter and remove the same from said localized area.

Claim 10

Dependent Claim 32 words

The method of claim 7 wherein the matter to be dissolved is selected from the group consisting of gall stones; kidney stones; blockages within the digestive system; cholesterol plaque and blood clots.

Claim 11

Dependent Claim 13 words

The method of claim 8 wherein the matter to be dissolved is gallstones.

Claim 12

Dependent Claim 28 words

The method of claim 7 wherein the localized area of a patients body is selected from the group consisting of: gallbladder; kidney; liver; biliary tract; intestine; and artery.

Claim 13

Dependent Claim 17 words

The method of claim 10 wherein the localized area of a patients body is the biliary tract.

Claim 14

Dependent Claim 14 words

The method of claim 7 wherein the oscillating liquid comprises the therapeutic dissolving agent.

Claim 15

Dependent Claim 18 words

The method of claim 12 wherein the oscillating liquid is introduced by means comprising a combined aspirator-injector pump.

Claim 16

Dependent Claim 35 words

The method of claim 13 wherein the oscillating liquid is maintained in a controlled volume range whereby make-up liquid can be introduced in the localized area to maintain the effective amount of oscillating liquid therein.

Claim 17

Dependent Claim 29 words

The method of claim 13 wherein the oscillating liquid is injected at a faster rate and for a shorter period of time than the oscillating liquid is alternately aspirated.

Claim 18

Dependent Claim 23 words

The method of claim 7 wherein the therapeutic dissolving agent is selected from the group consisting of mono-octanoion and methyl tertiary butyl ether.

Claim 19

Dependent Claim 44 words

The method of claim 12 wherein the oscillating liquid is introduced to the localized area by means selected from the group consisting of percutaneous transhepatic catheter placement; endoscopic retrograde biliary catheter placement; and placement of a t-tube into the localized area by surgical means.

Claim 20

Dependent Claim 16 words

The method of claim 17 wherein the catheter means comprise a fine needle or flexible catheter.

Claim 21

Independent Claim 83 words

A method for distributing a liquid therapeutic dissolving agent in the biliary tract of a patient to dissolve gallstones residing therein comprising oscillatingly introducing effective amounts of said therapeutic dissolving agent to said biliary tract by alternately injecting and aspirating said therapeutic agent along or with an oscillating liquid to and from said biliary tract so as to thereby distribute by agitation said therapeutic agent in said biliary tract and contact and dissolve said gallstones and remove the same form said biliary tract.

Claim 22

Independent Claim 83 words

A method for distributing a liquid therapeutic dissolving agent in the biliary tract of a patient to dissolve gallstones residing therein comprising oscillatingly introducing effective amounts of said therapeutic dissolving agent to said biliary tract by alternately injecting and aspirating said therapeutic agent along or with an oscillating liquid to and from said biliary tract so as to thereby distribute by agitation said therapeutic agent in said biliary tract and contact and dissolve said gallstones and remove the same form said biliary tract.

Claim 23

Dependent Claim 15 words

A method as in claim 19 wherein said oscillating liquid comprises said therapeutic dissolving agent.

Claim 24

Dependent Claim 19 words

A method as in claim 20 wherein said oscillating liquid is introduced by means comprising a combined aspirator-injector pump.

Claim 25

Dependent Claim 23 words

A method as in claim 20 wherein said oscillating liquid is selected from the group consisting of mono-octanoin and methyl tertiary butyl ether.

Claim 26

Dependent Claim 15 words

A method as in claim 22 wherein said oscillating liquid is methyl tertiary butyl ether.

Claim 27

Independent Claim 78 words

A method for distributing a liquid therapeutic dissolving agent in the gallbladder of a patient to dissolve gallstones residing therein comprising oscillatingly introducing effective amounts of said therapeutic dissolving agent to said gallbladder by alternately injecting and aspirating said therapeutic agent alone or with an oscillating liquid to and from said gallbladder so as to thereby distribute by agitation said therapeutic agent in said gallbladder and contact and dissolve said gallstones and remove the same from said gallbladder.

Claim 28

Independent Claim 78 words

A method for distributing a liquid therapeutic dissolving agent in the gallbladder of a patient to dissolve gallstones residing therein comprising oscillatingly introducing effective amounts of said therapeutic dissolving agent to said gallbladder by alternately injecting and aspirating said therapeutic agent alone or with an oscillating liquid to and from said gallbladder so as to thereby distribute by agitation said therapeutic agent in said gallbladder and contact and dissolve said gallstones and remove the same from said gallbladder.

Claim 29

Dependent Claim 14 words

A method as in claim 24 wherein said oscillating liquid comprises said therapeutic agent.

Claim 30

Dependent Claim 19 words

A method as in claim 25 wherein said oscillating liquid is introduced by means comprising a combined aspirator-injector pump.

Claim 31

Dependent Claim 23 words

A method as in claim 25 wherein said oscillating liquid is selected from the group consisting of mono-octanoin and methyl tertiary butyl ether.

Claim 32

Dependent Claim 15 words

A method as in claim 27 wherein said oscillating liquid is methyl tertiary butyl ether.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1991-07-05	1992-01-04	1992-07-05	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1995-07-05	1996-01-04	1996-07-05	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	1999-07-05	2000-01-04	2000-07-05	$7700.00	Window Closed / Lapsed

In vivo method for distribution and stirring of therapeutic agents

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