US4748018A
Expired / Lapsed
US
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Method of passive immunization of mammals using avian antibody
Assignee: STOLLE EGG BIOLOGICS INTERNATIONAL
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Filing: 1984-06-19
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Granted: 1988-05-31
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Expires: 2004-06-19
Abstract
Abstract A method of passively immunizing a mammal against a condition caused by an antigen comprising: administering to the mammal immunizing amounts of an antibody obtained from a domesticated fowl which has been immunized against the antigen; the mammal being tolerant to the antibody by virtue of having a history of consumption of antibody containing material derived from the egg of a fowl.
Inventors
- 👤 Ralph J. Stolle
- 👤 Lee R. Beck
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:07
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/04; A; A61; A61P; A61P31/00; A61P31/04; A61P37/00; C07K16/02; C07K16/12; C07K16/1267; C07K16/1275; A61K; A61K39/00; A61K2039/505; A61K2039/507; A61K2039/54; A61K2039/541; A61K2039/542; C07K2317/00; C07K2317/20; C07K2317/23
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
80 words
A method of passive immunization of a mammal against a condition caused by an antigen, which comprises: (a) feeding said mammal a material, said material comprising heterologous protein antibody, having an enhanced antibody titer against said antigen obtained from the egg of a domesticated fowl immunized against said antigen, until said mammal develops substantial tolerance to said antibody; and (b) administering to said mammal an immunologically effective amount of an antibody obtained from a domesticated fowl immunized against said antigen.
Claim 2
Independent Claim
80 words
A method of passive immunization of a mammal against a condition caused by an antigen, which comprises: (a) feeding said mammal a material, said material comprising heterologous protein antibody, having an enhanced antibody titer against said antigen obtained from the egg of a domesticated fowl immunized against said antigen, until said mammal develops substantial tolerance to said antibody; and (b) administering to said mammal an immunologically effective amount of an antibody obtained from a domesticated fowl immunized against said antigen.
Claim 3
Dependent Claim
16 words
The method of claim 1 wherein, in said step (a), said mammal is fed whole eggs.
Claim 4
Dependent Claim
16 words
The method of claim 1 wherein, in said step (a), said mammal is fed egg yolk.
Claim 5
Dependent Claim
15 words
The method of claim 1 wherein, in said step (b), said administration is by injection.
Claim 6
Dependent Claim
15 words
The method of claim 1 wherein the condition caused by the antigen is dental caries.
Claim 7
Dependent Claim
15 words
The method of claim 1 wherein the condition caused by the antigen is dental plaque.
Claim 8
Dependent Claim
25 words
The method of claim 1 wherein, in said step (a), said eggs have an enhanced antibody titer against a multiplicity of antigens including said antigen.
Claim 9
Dependent Claim
23 words
The method of claim 1 wherein, in said step (b), said fowl is the same individual as the one used in step (a).
Claim 10
Dependent Claim
25 words
The method of claim 1 wherein, in said step (b), said domesticated fowl is a different individual as the one used in said step (a).
Claim 11
Dependent Claim
12 words
The method of claim 1 wherein said mammal is a non-human mammal.
Claim 12
Dependent Claim
30 words
The method of claim 10 wherein said mammal is selected from the group consisting of a rabbit, a bovid, a horse, a goat, a sheep, an ape, and a monkey.
Claim 13
Dependent Claim
13 words
The method of said claim 1 wherein said mammal is a human being.
Claim 14
Dependent Claim
23 words
The method of claim 1 wherein said antigen is a bacterial species, product of a bacterial species, or a combination of bacterial species.
Claim 15
Dependent Claim
23 words
The method of claim 1 wherein said antigen is a viral species, product of a viral species, or a combination of viral species.
Claim 16
Dependent Claim
12 words
The method of claim 1 wherein said antigen is a bioregulatory substance.
Claim 17
Dependent Claim
16 words
The method of claim 15 wherein said bioregulatory substance is a hormone, enzyme, or immune-regulatory factor.
Claim 18
Dependent Claim
11 words
The method of claim 1 wherein said antigen is a polypeptide.
Claim 19
Dependent Claim
16 words
The method of claim 17 wherein said polypeptide is snake venom toxin or bee venom toxin.
Claim 20
Dependent Claim
11 words
The method of claim 1 wherein said passive immunization is preventive.
Claim 21
Dependent Claim
11 words
The method of claim 1 wherein said passive immunization is paliative.
Claim 22
Dependent Claim
38 words
The method of claim 1 wherein, in step (a), said material is fed to said mammal together with material having an enhanced antibody titer against said antigen obtained from the milk of a bovid immunized against said antigen.
Claim 23
Independent Claim
46 words
The method of any of claims 1 or 21 wherein, in step (b), said antibody is administered to said mammal together with antibody purified from milk of a bovid immunized against said antigen, and wherein said combination of antibodies is administered in an immunologically effective amount.
Claim 24
Dependent Claim
11 words
The method of claim 22 wherein said administration is by injection.
Claim 25
Dependent Claim
17 words
The method of claim 1 wherein said domesticated fowl in steps (a) and (b) is a chicken.
Claim 26
Dependent Claim
20 words
The method of claim 1 wherein, in step (b), said antibody is purified from the egg of said domesticated fowl.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-05-31 | 1991-11-30 | 1992-05-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-05-31 | 1995-11-30 | 1996-05-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-05-31 | 1999-11-30 | 2000-05-31 | $7700.00 | Window Closed / Lapsed |