US4732155A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Implantable chemoattractant system
Assignee: Boston Children's Hospital
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Filing: 1985-08-27
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Granted: 1988-03-22
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Expires: 2005-08-27
Abstract
Abstract A system for providing sustained prolonged release of a chemoattractant to a surrounding biological medium which contains cells responsive to the chemoattractant. The system consists of a biocompatible, non-inflammatory body, which sequesters the chemoattractant and allows sustained prolonged release of the chemoattractant from at least one part of the body. A cell trap is positioned adjacent to the releasing portion of the body, so that the released chemoattractant is transmitted through the trap and attracted cells are trapped in it.
Inventors
- 👤 Bruce R. Zetter
- 👤 Robert S. Langer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:20
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
95 words
A device for providing sustained, prolonged release of a chemoattractant to cells in a surrounding biological medium and for trapping cells attracted by said chemoattractant, said device comprising: (a) a biocompatible non-inflammatory body comprising said chemoattractant sequestered therein, said body providing sustained prolonged release of said chemoattractant from at least a portion thereof, and (b) a cell trap comprising a non-inflammatory wettable material attached to said body, chemoattractant released from said body being transmitted through said trap, and cells attracted by said chemoattractant released from said body being trapped by and retained within said trap.
Claim 2
Independent Claim
95 words
A device for providing sustained, prolonged release of a chemoattractant to cells in a surrounding biological medium and for trapping cells attracted by said chemoattractant, said device comprising: (a) a biocompatible non-inflammatory body comprising said chemoattractant sequestered therein, said body providing sustained prolonged release of said chemoattractant from at least a portion thereof, and (b) a cell trap comprising a non-inflammatory wettable material attached to said body, chemoattractant released from said body being transmitted through said trap, and cells attracted by said chemoattractant released from said body being trapped by and retained within said trap.
Claim 3
Dependent Claim
20 words
The device of claim 1 wherein said body comprises a polymer matrix impermeable to said cells and to said chemoattractant.
Claim 4
Dependent Claim
14 words
The device of claim 2 wherein said polymer is an ethylene vinyl acetate copolymer.
Claim 5
Dependent Claim
34 words
The device of claim 1 wherein said cell trap comprises a web which allows penetration by cells attracted to said chemical, said web being capable of being fixed and sectioned to examine said cells.
Claim 6
Dependent Claim
37 words
The device of claim 1 wherein said cell trap comprises a polymer having openings larger than said cells, said polymer exhibiting a surface attraction for said cells whereby cells entering said openings are retained in said trap.
Claim 7
Dependent Claim
11 words
The device of claim 5 wherein said surface attraction is electrostatic.
Claim 8
Dependent Claim
15 words
The device of claim 4 or 5 wherein said trap comprises a synthetic polyester fiber.
Claim 9
Dependent Claim
42 words
The device of claim 1 wherein said chemoattractant is chosen from: (a) histamine (b) tuftsin (c) Glycyl-Histidyl-Lysine. (d) Alanyl-Glycyl-Seryl-Glutamine (e) f-Methionyl-Leucyl-Phenylalanine (f) Glycyl-Histidyl-Glycine (g) Valinyl-Glycyl-Seryl-Glutamine (h) collagen Type I (i) epidermal growth factor (j) endotoxin standard (k) prostaglandin E and (1) heparin.
Claim 10
Dependent Claim
14 words
The device of claim 1 wherein said body is configured to provide directional release.
Claim 11
Dependent Claim
39 words
The device of claim 1 wherein only a portion of the surface of said body releases said chemoattractant and said portion comprises less than 1/4 of the surface area of said body to provide directional release of said chemoattractant.
Claim 12
Dependent Claim
35 words
The device of claim 1 wherein said cells comprise a heterogenous group of cells, and said trap is adapted to be sectioned to determine the cell species in said cell group that are trapped therein.
Claim 13
Dependent Claim
17 words
The device of claim 11 wherein said chemoattractant is a substance to be evaluated for allergenic activity.
Claim 14
Dependent Claim
14 words
The device of claim 11 wherein said cell group comprises neutrophiles, monocytes, and macrophages.
Claim 15
Dependent Claim
11 words
The device of claim 1 wherein said cell trap comprises polyester.
Claim 16
Dependent Claim
48 words
A method of measuring the ability of a chemoattractant to attract cells, send method comprising providing the device of claim 1 comprising said chemoattractant sequestered in said body; contacting said device with a medium comprising said cells; and then determining the presence of cells trapped in said trap.
Claim 17
Dependent Claim
17 words
The method of claim 15 wherein said contacting step comprises implanting said device within a living animal.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-03-22 | 1991-09-21 | 1992-03-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-03-22 | 1995-09-21 | 1996-03-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-03-22 | 1999-09-21 | 2000-03-22 | $7700.00 | Window Closed / Lapsed |