US4716117A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Monoclonal antibodies to factor VIIIC
Assignee: Novo Nordisk AS
•
Filing: 1985-01-07
•
Granted: 1987-12-29
•
Expires: 2005-01-07
Abstract
Abstract Hybridomas producing monoclonal antibodies specific for polypeptide fragments derived from human Factor VIIIC are provided. Class I hybridomas produce monoclonal antibodies reactive with a 80/77 kd doublet fragment or with both the 80/77 kd doublet and a 240 kd polypeptide. Class III hybridomas produce monoclonal antibodies reactive with the 240 kd polypeptide as well as a 92.5 kd fragment and its precursors. Class III antibodies show additional reactivity with a 40 kd thrombin digestion product. The monoclonal antibodies are useful for the separation of Factor VIIIC and its constituent polypeptides, as well as for the immunoassay of Factor VIIIC in biological samples.
Inventors
- 👤 George Kuo
- 👤 Frank R. Masiarz
- 👤 Martha Truett
- 👤 Pablo Valenzuela
- 👤 Mirella E. Rasmussen
- 👤 Jennifer Favaloro
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:44
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/745; C07K14/755; C07K16/00; C07K16/18; C07K16/36; C12; C12Q; C12Q1/00; C12Q1/68; C12Q1/6876; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
32 words
A hybridoma cell line selected from the group consisting of cell line 42, cell line 47, cell line 56, cell line 1-28, cell line 4E5, cell line 5B1, and, cell line 2B6.
Claim 2
Dependent Claim
32 words
A hybridoma cell line selected from the group consisting of cell line 42, cell line 47, cell line 56, cell line 1-28, cell line 4E5, cell line 5B1, and, cell line 2B6.
Claim 3
Dependent Claim
13 words
Monoclonal antibodies obtained from any of the hybridoma cell lines of claim 1.
Claim 4
Dependent Claim
27 words
A hybridoma cell line producing monoclonal antibodies that block the binding of any of the monoclonal antibodies of claim 2 to their epitope in a competition assay.
Claim 5
Dependent Claim
13 words
Monoclonal antibodies obtained from any of the hybridoma cell lines of claim 3.
References Cited (Backward Citations)
US4361509A
Cited
EP0123945A1
Cited
US4649132A
Cited
US4657894A
Cited
WO1984004541A1
Cited
WO1985001961A1
Cited
EP0160457A1
Cited
EP0182372A2
Cited
EP1157556A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-12-28 | 1991-06-29 | 1991-12-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-12-28 | 1995-06-29 | 1995-12-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-12-28 | 1999-06-29 | 1999-12-29 | $7700.00 | Window Closed / Lapsed |