US4713249A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Crystallized carbohydrate matrix for biologically active substances, a process of preparing said matrix, and the use thereof
Assignee: Individual
•
Filing: 1983-07-04
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Granted: 1987-12-15
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Expires: 2003-07-04
Abstract
Abstract The invention shows that it is possible to produce a depot matrix for biologically active substances, consisting of carbohydrate microspheres, such that the carbohydrate polymers included in the microsphere are stabilized to a microsphere by crystallization, which implies using non-covalent bonds, the substance enclosed retaining its biological activity.
Inventors
- 👤 Ulf Schroder
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:41
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/51; A61K9/5107; A61K9/513; A61K9/5161; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/61; A61K9/14; A61K9/16; A61K9/1605; A61K9/1617; A61K9/1623; A61K9/1629; A61K9/1652; A61K9/1682; A61K9/1694; A61K9/5094; A61K9/5192; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2989
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
38 words
A composition useful for the prolonged release of a biologically-active substance comprising a sphere or particle comprising a non-covalently cross-linked crystalline polymeric carbohydrate matrix, said matrix incorporating 0.001-50% by weight of an absorbed or covalently bonded biologically-active substance.
Claim 2
Dependent Claim
38 words
A composition useful for the prolonged release of a biologically-active substance comprising a sphere or particle comprising a non-covalently cross-linked crystalline polymeric carbohydrate matrix, said matrix incorporating 0.001-50% by weight of an absorbed or covalently bonded biologically-active substance.
Claim 3
Dependent Claim
20 words
The composition of claim 1 wherein said sphere or particle has an average diameter within the range of 0.01-1,000 μm.
Claim 4
Dependent Claim
20 words
The composition of claim 1 wherein said sphere or particle has an average diameter within the range of 0.01-1.0 μm.
Claim 5
Dependent Claim
21 words
The composition of claim 1 wherein said carbohydrate is selected from the group consisting of dextran, starch and the derivatives thereof.
Claim 6
Dependent Claim
26 words
The composition of claim 1 wherein the carbohydrate is selected from the group consisting of alginate, chitosan, agarose, carrageenan, cellulose, glycogen, pullullan and the derivatives thereof.
Claim 7
Dependent Claim
12 words
The composition of claim 1 wherein said biologically-active substance is an antigen.
Claim 8
Dependent Claim
11 words
The composition of claim 1 wherein the biologically-active substance is insulin.
Claim 9
Dependent Claim
12 words
The composition of claim 1 wherein the biologically-active substance is an allergen.
Claim 10
Dependent Claim
13 words
The composition of claim 1 wherein the biologically-active substance is a growth hormone.
Claim 11
Dependent Claim
85 words
A process for producing a composition useful for the prolonged release of a biologically-active substance, comprising, (a) forming a solution of a polymeric carbohydrate and a biologically-active substance in one or more hydrophillic solvents; (b) emulsifying the mixture of the carbohydrate and the biologically active substance in a liquid hydrophobic medium to form spherical droplets; and (c) introducing the emulsion into a crystallizing medium to form spheres having a non-covalently cross-linked crystalline polymeric carbohydrate matrix, said matrix incorporating 0.001-50% by weight of the biologically-active substance.
Claim 12
Dependent Claim
85 words
A process for producing a composition useful for the prolonged release of a biologically-active substance, comprising, (a) forming a solution of a polymeric carbohydrate and a biologically-active substance in one or more hydrophillic solvents; (b) emulsifying the mixture of the carbohydrate and the biologically active substance in a liquid hydrophobic medium to form spherical droplets; and (c) introducing the emulsion into a crystallizing medium to form spheres having a non-covalently cross-linked crystalline polymeric carbohydrate matrix, said matrix incorporating 0.001-50% by weight of the biologically-active substance.
Claim 13
Dependent Claim
22 words
The process of claim 10 wherein the droplets are crystallized by introducing them into a crystallizing medium comprising acetone, ethanol or methanol.
Claim 14
Dependent Claim
23 words
The process of claim 10 wherein the emulsification is conducted at 4°-40° C. so that the activity of the biologically-active substance is preserved.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-12-14 | 1991-06-15 | 1991-12-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-12-14 | 1995-06-15 | 1995-12-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-12-14 | 1999-06-15 | 1999-12-15 | $7700.00 | Window Closed / Lapsed |