US4704273A
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Methods and materials for treatment of rheumatoid arthritis
Assignee: Molecular Rx Inc
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Filing: 1986-02-27
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Granted: 1987-11-03
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Expires: 2006-02-27
Abstract
Abstract Disclosed are methods and compositions useful for alleviating the symptoms of rheumatoid arthritis. In preferred embodiments, the compositions are administered in essentially minute "neutralizing" doses. The compositions comprise mixtures of histamine, immunoglobulin G provocative of RF formation or an immunologically active fraction thereof, collagen and either attenuated measles virus or immunologically active fraction thereof. Illustratively significant relief of symptoms of arthritis disease symptoms is achieved through parenteral (e.g., subcutaneous or sublingual) administration of such compositions.
Inventors
- 👤 John McMichael
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:11
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/415; A61K35/00; A61K35/66; A61K35/76; A61K38/00; A61K38/16; A61K38/17; A61K38/39; A61K39/00; A61K39/0005; A61K39/0008; A61K39/12; A61K39/155; A61K39/165; A61K39/395; A61K2039/51; A61K2039/525; A61K2039/5252; A61K2039/54; A61K2039/541; A61K2039/542; A61K2039/58; C; C12; C12N; C12N2760/00; C12N2760/00011; C12N2760/16011; C12N2760/16111; C12N2760/16134; C12N2760/18011; C12N2760/18411; C12N2760/18433; C12N2760/18434; C12N2760/18711; C12N2760/18734; Y; Y10; Y10S; Y10S424/00; Y10S424/81
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
50 words
A method for alleviating the symptoms of rheumatoid arthritis comprising administering to the disease victim an effective amount of a composition comprising a mixture of histamine, immunoglobulin G provocative of rheumatoid factor formation or an immunologically active fraction thereof, collagen and attenuated measles virus or an immunologically active fraction thereof.
Claim 2
Independent Claim
50 words
A method for alleviating the symptoms of rheumatoid arthritis comprising administering to the disease victim an effective amount of a composition comprising a mixture of histamine, immunoglobulin G provocative of rheumatoid factor formation or an immunologically active fraction thereof, collagen and attenuated measles virus or an immunologically active fraction thereof.
Claim 3
Dependent Claim
18 words
The method of claim 1 wherein histamine is administered in the form of a water soluble histamine salt.
Claim 4
Dependent Claim
25 words
The method of claim 1 wherein said composition comprises, in unit dosage form, from about 8.8×10 -6 to about 5.5×10 -3 mg of histamine phosphate.
Claim 5
Dependent Claim
25 words
The method of claim 1 wherein said composition comprises, in unit dosage form, from about 0.1 to about 0.005 mg of chromatographically pure immunoglobulin G.
Claim 6
Dependent Claim
13 words
The method of claim 4 wherein the immunoglobulin G is human immunoglobulin G.
Claim 7
Dependent Claim
25 words
The method of claim 1 wherein said composition comprises, in unit dosage form, from about 0.4 to about 10 TCID 50 of attenuated measles virus.
Claim 8
Dependent Claim
24 words
The method of claim 1 wherein said composition comprises, in unit dosage form, from about 4×10 -3 to about 1×10 -1 mg of collagen.
Claim 9
Dependent Claim
11 words
The method of claim 1 wherein said composition is administered parenterally.
Claim 10
Dependent Claim
13 words
The method of claim 8 wherein said composition is administered subcutaneously or sublingually.
Claim 11
Dependent Claim
20 words
A composition of matter comprising a mixture of histamine, immunoglobulin G provocative of RF formation, collagen and attenuated measles virus.
Claim 12
Dependent Claim
20 words
A composition of matter comprising a mixture of histamine, immunoglobulin G provocative of RF formation, collagen and attenuated measles virus.
Claim 13
Dependent Claim
18 words
A composition according to claim 10 wherein histamine is in the form of a water soluble histamine salt.
Claim 14
Dependent Claim
23 words
A composition according to claim 10 comprising, in unit dosage form, from about 8.8×10 -6 to about 5.5×10 -3 mg of histamine phosphate.
Claim 15
Dependent Claim
23 words
A composition according to claim 10 comprising, in unit dosage form, from about 0.1 to about 0.005 mg of chromatographically pure immunoglobulin G.
Claim 16
Dependent Claim
13 words
A composition according to claim 13 wherein the immunoglobulin is human immunoglobulin G.
Claim 17
Dependent Claim
23 words
A composition according to claim 10 comprising, in unit dosage form, from about 0.4 to about 10 TCID 50 of attenuated measles virus.
Claim 18
Dependent Claim
22 words
A composition according to claim 10 comprising, in unit dosage form, from about 4×10 -3 to about 1×10 -1 mg of collagen.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-11-02 | 1991-05-04 | 1991-11-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-11-02 | 1995-05-04 | 1995-11-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-11-02 | 1999-05-04 | 1999-11-03 | $7700.00 | Window Closed / Lapsed |