Patent US5399158A successfully refreshed from Google Patents.
US4699141A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Neovascularization
Assignee: RHODE ISLAND HOSPITAL PROVIDENCE RHODE ISLAND A CORP OF RHODE ISLAND
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Filing: 1986-01-16
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Granted: 1987-10-13
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Expires: 2006-01-16
Abstract
Abstract Neovascularization is caused by placing a ligated blood vessel, preferably in an artery, in a sponge made of a material permitting vessel growth therein and therethrough, the material preferably being an acrylic copolymer carrying therein collagen and thereon heparin and fibrinogen, there being also in a preferred embodiment a cell receptacle with a molecular weight cutoff permeable walls within the sponge.
Inventors
- 👤 Robert P. Lamberton
- 👤 Milton H. Lipsky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 08:10
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/56; A61F; A61F2/00; A61F2/02; A61F2/022; A61F2/04; A61F2/06; A61L27/14; A61L27/18; A61L27/26; A61L27/36; A61L27/54; A61L2300/00; A61L2300/20; A61L2300/23; A61L2300/236; A61L2300/252; A61L2300/40; A61L2300/412
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
116 words
A surgically implantable container for transplanted cells, comprising, a sponge body formed of a spongy material adapted to permit growth therein of capillary blood vessels when said sponge is placed adjacent to or surrounding a larger noncapillary blood vessel, and a semipermeable membrane receptacle for containing living transplanted cells mounted in said sponge body in position to communicate with blood in said growing capillary vessels, said receptacle having pores with a predetermined molecular weight cutoff size to retain cells therein and to prevent passage of bodies that would cause rejection of the cells but to permit passage of nutrients to the interior of said receptacle and the transport out of the receptacle of chemicals created therein.
Claim 2
Dependent Claim
116 words
A surgically implantable container for transplanted cells, comprising, a sponge body formed of a spongy material adapted to permit growth therein of capillary blood vessels when said sponge is placed adjacent to or surrounding a larger noncapillary blood vessel, and a semipermeable membrane receptacle for containing living transplanted cells mounted in said sponge body in position to communicate with blood in said growing capillary vessels, said receptacle having pores with a predetermined molecular weight cutoff size to retain cells therein and to prevent passage of bodies that would cause rejection of the cells but to permit passage of nutrients to the interior of said receptacle and the transport out of the receptacle of chemicals created therein.
Claim 3
Dependent Claim
15 words
The container of claim 1 in which said sponge body is formed of acrylic copolymer.
Claim 4
Dependent Claim
16 words
The container of claim 2 in which said receptacle is formed of acrylic copolymer hollow fiber.
Claim 5
Dependent Claim
25 words
The container of claim 1 in which said sponge body carries in said material or thereon fibrinogen, heparin, or collagen additives to facilitate said growth.
Claim 6
Independent Claim
112 words
The method of transplanting cells which comprises placing a noncapillary blood vessel within or adjacent to a spongy material adapted to permit growth therein of capillary blood vessels, and providing in said spongy material a semipermeable membrane receptacle containing living transplanted cells, said receptacle being mounted in said spongy material in position to communicate with blood in said growing capillary vessels, said receptacle having pores with a predetermined molecular weight cutoff size to retain cells therein and to prevent passage of bodies that would cause rejection of the cells but to permit passage of nutrients to the interior of said receptacle and the transport out of the receptacle of chemicals created therein.
Claim 7
Independent Claim
112 words
The method of transplanting cells which comprises placing a noncapillary blood vessel within or adjacent to a spongy material adapted to permit growth therein of capillary blood vessels, and providing in said spongy material a semipermeable membrane receptacle containing living transplanted cells, said receptacle being mounted in said spongy material in position to communicate with blood in said growing capillary vessels, said receptacle having pores with a predetermined molecular weight cutoff size to retain cells therein and to prevent passage of bodies that would cause rejection of the cells but to permit passage of nutrients to the interior of said receptacle and the transport out of the receptacle of chemicals created therein.
Claim 8
Dependent Claim
13 words
The method of claim 5 in which said vessel is a ligated artery.
Claim 9
Dependent Claim
14 words
The method of claim 5 in which said spongy material comprises an acrylic copolymer.
Claim 10
Dependent Claim
26 words
The method of claim 7 in which said spongy material includes therein or thereon or both fibrogen, heparin, or collagen materials tending to encourage said growth.
Claim 11
Dependent Claim
23 words
The method of claim 7 in which said one or more materials is one or more or all of collagen, heparin, and fibrinogen.
Claim 12
Dependent Claim
14 words
The container claim 2 in which said sponge body is formed of polyurethane isocyanate.
Claim 13
Dependent Claim
15 words
The container of claim 3 in which said receptacle is a polyurethane isocyanate hollow fiber.
Claim 14
Dependent Claim
17 words
The container of claim 11 in which the ends of said fiber are sealed with polyurethane isocyanate.
Claim 15
Dependent Claim
28 words
The method of claim 5 wherein said providing includes providing an empty receptacle, waiting for said capillary blood vessels to grow, and placing said cells in said receptacle.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-10-12 | 1991-04-13 | 1991-10-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-10-12 | 1995-04-13 | 1995-10-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-10-12 | 1999-04-13 | 1999-10-13 | $7700.00 | Window Closed / Lapsed |