US4665060A
Expired / Lapsed
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Therapeutic treatment employing oligosaccharides
Assignee: Biocarb AB
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Filing: 1983-03-22
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Granted: 1987-05-12
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Expires: 2003-03-22
Abstract
Abstract A composition for therapeutic or diagnostic use in regard to pathogenic microorganisms, containing as an active constituent a structural element having the formula: <IMAGE> II wherein R1, R2, R3 and R4 are same or different and are hydrogen or an organic residue, for example lower alkyl, lower acyl, or a carbohydrate residue or an inorganic residue, such as sulphate or phosphate, and wherein OR1 is in alpha - or beta -configuration; a process for therapeutic treatment; a process for identification or quantification of the said structural element in native biological material; a process for purifying acceptor structures of bacteria; and a process for performing disinfection on surfaces.
Inventors
- 👤 Per A. Mardh
- 👤 Sigfrid Svensson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:27
CPC Classifications
A; A01; A01N; A01N43/00; A01N43/02; A01N43/04; A01N43/14; A01N43/16; A61; A61L; A61L2/00; A61L2/16; A61P; A61P31/00; A61P31/04; C; C07; C07H; C07H3/00; C07H3/06; C07K; C07K16/00; C07K16/12; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/531; G01N33/543; G01N33/54353; G01N33/566; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/882
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
84 words
A method of inhibiting the adherence of microorganisms to mammalian cells comprising treating a mammal with a compound having the formula: ##STR9## wherein R 1 , R 2 and R 3 are same or different and are hydrogen, lower alkyl, lower acyl, or a carbohydrate residue selected from the group consisting of: ##STR10## or an inorganic residue selected from the group consisting of sulfate and phosphate, and wherein OR 1 is in α- or β-configuration, to provide adherence between the microorganism and the compound.
Claim 2
Independent Claim
84 words
A method of inhibiting the adherence of microorganisms to mammalian cells comprising treating a mammal with a compound having the formula: ##STR9## wherein R 1 , R 2 and R 3 are same or different and are hydrogen, lower alkyl, lower acyl, or a carbohydrate residue selected from the group consisting of: ##STR10## or an inorganic residue selected from the group consisting of sulfate and phosphate, and wherein OR 1 is in α- or β-configuration, to provide adherence between the microorganism and the compound.
Claim 3
Dependent Claim
18 words
A method according to claim 1, wherein in said compound R 2 and R 3 are both hydrogen.
Claim 4
Dependent Claim
15 words
A method according to claim 1, wherein in said compound OR 1 is in β-configuration.
Claim 5
Dependent Claim
11 words
A method according to claim 3, wherein R 1 is methyl.
Claim 6
Dependent Claim
16 words
A method according to claim 1, wherein R 1 is a group having the formula: ##STR11##
Claim 7
Dependent Claim
16 words
A method according to claim 1, wherein R 1 is a group having the formula: ##STR12##
Claim 8
Dependent Claim
11 words
A method according to claim 1, wherein R 1 is hydrogen.
Claim 9
Dependent Claim
14 words
A method according to claim 1, wherein the mammalian cells are human epithelial cells.
Claim 10
Independent Claim
87 words
A method for the treatment of gram positive bacterial infections in a mammalian organism comprising administering to a mammalian organism in need of such treatment an effective amount of a compound having the formula: ##STR13## wherein R 1 ,R 2 and R 3 are same or different and are hydrogen, lower alkyl, lower acyl, or a carbohydrate residue selected from the group consisting of ##STR14## or an inorganic residue selected from the group consisting of sulfate and phosphate, and wherein OR 1 is in α- or β-configuration.
Claim 11
Independent Claim
87 words
A method for the treatment of gram positive bacterial infections in a mammalian organism comprising administering to a mammalian organism in need of such treatment an effective amount of a compound having the formula: ##STR13## wherein R 1 ,R 2 and R 3 are same or different and are hydrogen, lower alkyl, lower acyl, or a carbohydrate residue selected from the group consisting of ##STR14## or an inorganic residue selected from the group consisting of sulfate and phosphate, and wherein OR 1 is in α- or β-configuration.
Claim 12
Dependent Claim
17 words
A method according to claim 9, wherein said compound R 2 and R 3 are both hydrogen.
Claim 13
Dependent Claim
14 words
A method according to claim 9, wherein said compound OR 1 is in β-configuration.
Claim 14
Dependent Claim
11 words
A method according to claim 11, wherein R 1 is methyl.
Claim 15
Dependent Claim
16 words
A method according to claim 9, wherein R 1 is a group having the formula: ##STR15##
Claim 16
Dependent Claim
16 words
A method according to claim 9, wherein R 1 is a group having the formula: ##STR16##
Claim 17
Dependent Claim
11 words
A method according to claim 9, wherein R 1 is hydrogen.
Claim 18
Dependent Claim
14 words
A method according to claim 9, wherein the mammalian cells are human eliphelial cells.
References Cited (Backward Citations)
US4362720A
Cited
US4251515A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1990-05-11 | 1990-11-10 | 1991-05-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-05-11 | 1994-11-10 | 1995-05-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-05-11 | 1998-11-10 | 1999-05-12 | $7700.00 | Window Closed / Lapsed |