US4650662A
Expired / Lapsed
US
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Portable blood typing apparatus and method
Assignee: Cedars-Sinai Medical Center
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Filing: 1984-11-13
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Granted: 1987-03-17
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Expires: 2004-11-13
Abstract
Abstract A portable apparatus to enable rapid determination of an individual's ABO blood group and Rh blood type and a method of using such apparatus. The apparatus has a plurality of microtubes joined together which contain blood taken from an individual. The assembly of microtubes is connected during use to an assembly of reaction chambers containing blood typing reagents. The apparatus enables rapid visualization of the test reactions within the reaction chambers, and may be used in locations removed from a laboratory to determine the ABO blood group and Rh blood type of an individual.
Inventors
- 👤 Dennis Goldfinger
- 👤 Rock C. Hsi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 06:49
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/80; Y; Y10; Y10S; Y10S435/00; Y10S435/81; Y10S436/00; Y10S436/807
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
136 words
A portable testing apparatus for determining a patient's ABO blood group using blood typing reagent agglutination reactions comprising: (a) a blood collection assembly having a plurality of microtubes for collecting the patient's blood sample; (b) a variable volume reaction chamber assembly for sealably receiving said blood collection assembly, including: (i) a plurality of reaction chambers formed by wall members to receive said microtubes; (ii) each of said reaction chambers having at least one nonresilient wall member; (iii) each of said reaction chambers having at least one resilient portion of a wall member; and (iv) a removable means abutting each of the reaction chambers so as to deform said reaction chambers inwardly at the resilient portion of the wall members, said removable means being held against said resilient portion of said wall members by a seal means.
Claim 2
Dependent Claim
136 words
A portable testing apparatus for determining a patient's ABO blood group using blood typing reagent agglutination reactions comprising: (a) a blood collection assembly having a plurality of microtubes for collecting the patient's blood sample; (b) a variable volume reaction chamber assembly for sealably receiving said blood collection assembly, including: (i) a plurality of reaction chambers formed by wall members to receive said microtubes; (ii) each of said reaction chambers having at least one nonresilient wall member; (iii) each of said reaction chambers having at least one resilient portion of a wall member; and (iv) a removable means abutting each of the reaction chambers so as to deform said reaction chambers inwardly at the resilient portion of the wall members, said removable means being held against said resilient portion of said wall members by a seal means.
Claim 3
Dependent Claim
32 words
An apparatus as defined in claim 1 wherein said reaction chambers are joined together in a linear configuration; said resilient portions of the wall members aligned along one side of the apparatus.
Claim 4
Dependent Claim
15 words
An apparatus according to claim 1 wherein said removable means consists of a compressible material.
Claim 5
Dependent Claim
15 words
An apparatus according to claim 1, wherein said removable means consists of a non-compressible material.
Claim 6
Dependent Claim
33 words
An apparatus according to claim 1 wherein said reaction chamber assembly receives the blood collection assembly so as to form an airtight seal between said blood collection assembly and said reaction chamber assembly.
Claim 7
Dependent Claim
69 words
An apparatus as defined in claim 5 wherein said airtight seal is formed by means for connecting said blood collection assembly to the reaction chamber assembly, said connecting means comprising: (a) a plurality of tapering collar elements integrally attached to said blood collection assembly into which said microtubes are inserted; and (b) apertures in each reaction chamber into which said tapering collar elements insert to form an airtight seal.
Claim 8
Dependent Claim
23 words
An apparatus as defined in claim 1 wherein said non-resilient wall members of said reaction chambers further include a portion with magnifying properties.
Claim 9
Dependent Claim
18 words
An apparatus as in claim 1, wherein said seal means is made of adhesive plastic or paper material.
Claim 10
Dependent Claim
24 words
An apparatus as in claim 1, further comprising blood typing reagents contained in liquid form in the interior of each of said reaction chambers.
Claim 11
Dependent Claim
24 words
An apparatus as in claim 1, further comprising blood typing reagents contained in freeze-dried form in the interior of each of said reaction chambers.
Claim 12
Dependent Claim
162 words
A portable testing apparatus for determining a patient's ABO blood group and Rh blood type using blood typing reagent agglutination reactions comprising: (a) a blood collection assembly having a plurality of microtubes for collecting the patient's blood sample; (b) a reaction chamber assembly for sealably receiving said blood collection assembly, including: (i) a plurality of reaction chambers formed by wall members to receive said microtubes; (ii) each of said reaction chambers having at least one non-resilient wall member; (iii) each of said reaction chambers having at least one resilient portion of a wall member, said resilient portion of the wall member of at least two reaction chambers having an inner resilient portion and an outer resilient portion, the inner and outer portions forming a heating compartment therebetween for catalyzing Rh typing reactions; (c) a chemical that produces heat when mixed with water contained at one end of said heating compartment; and (d) water contained at an opposite end of said heating compartment.
Claim 13
Dependent Claim
162 words
A portable testing apparatus for determining a patient's ABO blood group and Rh blood type using blood typing reagent agglutination reactions comprising: (a) a blood collection assembly having a plurality of microtubes for collecting the patient's blood sample; (b) a reaction chamber assembly for sealably receiving said blood collection assembly, including: (i) a plurality of reaction chambers formed by wall members to receive said microtubes; (ii) each of said reaction chambers having at least one non-resilient wall member; (iii) each of said reaction chambers having at least one resilient portion of a wall member, said resilient portion of the wall member of at least two reaction chambers having an inner resilient portion and an outer resilient portion, the inner and outer portions forming a heating compartment therebetween for catalyzing Rh typing reactions; (c) a chemical that produces heat when mixed with water contained at one end of said heating compartment; and (d) water contained at an opposite end of said heating compartment.
Claim 14
Dependent Claim
13 words
An apparatus as defined in claim 11 wherein said chemical is sodium hydroxide.
Claim 15
Dependent Claim
33 words
An apparatus according to claim 11, wherein said reaction chamber assembly receives the blood collection assembly so as to form an airtight seal between said blood collection assembly and said reaction chamber assembly.
Claim 16
Dependent Claim
37 words
An apparatus as defined in claim 11 wherein said apparatus further includes a removable means abutting each of the reaction chambers so as to deform each reaction chamber inwardly at the resilient portion of a wall member.
Claim 17
Independent Claim
295 words
A method for determining a patient's ABO and Rh blood type, comprising the steps of: (a) obtaining a blood sample from the patient; (b) filling a plurality of microtubes with the blood sample by contacting the tubes to the patient's blood; (c) connecting said microtubes to a reaction chamber assembly wherein said reaction chamber assembly includes: (i) a plurality of reaction chambers formed by wall members; (ii) each of said reaction chamber having at least one resilient portion of a wall member, and said resilient portion of the wall member of at least two reaction chambers having an inner resilient portion and an outer resilient portion, the inner and outer portions forming a heating compartment therebetween; (iii) a chemical that produces heat when mixed with water contained at one end of said heating compartment; (iv) water contained at an opposite end of said heating compartment; (v) a removable means abutting each of the reaction chambers so as to deform said reaction chambers inwardly at the resilient portions and form said one end and said opposite end; (d) causing the blood sample to flow from the microtubes into the plurality of reaction chambers; (e) mixing said blood samples and blood typing reagents in said reaction chambers; (f) heating the mixture of blood sample and Rh blood typing reagents in said reaction chambers; (g) observing said mixtures in the reaction chambers for agglutination; Wherein said step of causing the blood sample to flow from the microtubes and said step of heating the mixture of blood sample and Rh blood typing reagents comprises removing said removable means to generate a negative pressure within the reaction chamber and to increase the volume of said heating compartment and simultaneously allow the water to contact the chemical within the heating compartment.
Claim 18
Independent Claim
295 words
A method for determining a patient's ABO and Rh blood type, comprising the steps of: (a) obtaining a blood sample from the patient; (b) filling a plurality of microtubes with the blood sample by contacting the tubes to the patient's blood; (c) connecting said microtubes to a reaction chamber assembly wherein said reaction chamber assembly includes: (i) a plurality of reaction chambers formed by wall members; (ii) each of said reaction chamber having at least one resilient portion of a wall member, and said resilient portion of the wall member of at least two reaction chambers having an inner resilient portion and an outer resilient portion, the inner and outer portions forming a heating compartment therebetween; (iii) a chemical that produces heat when mixed with water contained at one end of said heating compartment; (iv) water contained at an opposite end of said heating compartment; (v) a removable means abutting each of the reaction chambers so as to deform said reaction chambers inwardly at the resilient portions and form said one end and said opposite end; (d) causing the blood sample to flow from the microtubes into the plurality of reaction chambers; (e) mixing said blood samples and blood typing reagents in said reaction chambers; (f) heating the mixture of blood sample and Rh blood typing reagents in said reaction chambers; (g) observing said mixtures in the reaction chambers for agglutination; Wherein said step of causing the blood sample to flow from the microtubes and said step of heating the mixture of blood sample and Rh blood typing reagents comprises removing said removable means to generate a negative pressure within the reaction chamber and to increase the volume of said heating compartment and simultaneously allow the water to contact the chemical within the heating compartment.
Claim 19
Dependent Claim
28 words
The method according to claim 15, wherein said step of connecting includes the step of inserting said microtubes into said reaction chamber assembly to form an airtight seal.
Claim 20
Dependent Claim
36 words
A method as in claim 15 wherein said step of heating further includes wating for said water and chemical reaction to heat said Rh typing reagents to a temperature between 40 degrees to 55 degrees centigrade.
Claim 21
Dependent Claim
29 words
A method as in claim 17 wherein said water and chemical reaction is allowed to continue for 2-3 minutes prior to the step of observing said mixtures for agglutination.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-03-16 | 1990-09-15 | 1991-03-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-03-16 | 1994-09-15 | 1995-03-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-03-16 | 1998-09-15 | 1999-03-17 | $7700.00 | Window Closed / Lapsed |