Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
169 words
A drug comprising: a mixture of porphyrins; at least some of the molecules of said porphyrin mixture having the molecular formula: ##STR10## said molecules with said formulae being fluorescent, photosensitizing, having the capability of localizing in and being retained in tumor tissue as compared to normal tissues, forming a high molecular weight aggregate with adsorption peaks in the visible spectrum in water at approximately 365, 505, 537, 575 and 615 nanometers, adsorption peaks in the infrared spectrum at approximately 3.0, 3.4, 6.4, 7.1, 8.1, 9.4, 12 and 15 microns, adsorption peaks in carbon-13 nuclear magnetic resonance study at approximately 9.0, 18.9, 24.7, 34.5, 62, 94.5, 130-145, 171.7 ppm and possibly 118 and 127 relative to a 37.5 ppm resonance peak of dimethyl sulfoxide and additional adsorption peaks in carbon-13 nuclear magnetic study at approximately 27.9 ppm and 68.4 ppm relative to the resonance peak of tetramethylsilane in deuterated chloroform solvent; and at least 50 percent of the porphyrins in said mixture being of said molecule having said molecular formula.
Claim 2
Dependent Claim
169 words
A drug comprising: a mixture of porphyrins; at least some of the molecules of said porphyrin mixture having the molecular formula: ##STR10## said molecules with said formulae being fluorescent, photosensitizing, having the capability of localizing in and being retained in tumor tissue as compared to normal tissues, forming a high molecular weight aggregate with adsorption peaks in the visible spectrum in water at approximately 365, 505, 537, 575 and 615 nanometers, adsorption peaks in the infrared spectrum at approximately 3.0, 3.4, 6.4, 7.1, 8.1, 9.4, 12 and 15 microns, adsorption peaks in carbon-13 nuclear magnetic resonance study at approximately 9.0, 18.9, 24.7, 34.5, 62, 94.5, 130-145, 171.7 ppm and possibly 118 and 127 relative to a 37.5 ppm resonance peak of dimethyl sulfoxide and additional adsorption peaks in carbon-13 nuclear magnetic study at approximately 27.9 ppm and 68.4 ppm relative to the resonance peak of tetramethylsilane in deuterated chloroform solvent; and at least 50 percent of the porphyrins in said mixture being of said molecule having said molecular formula.
Claim 3
Dependent Claim
31 words
A drug in accordance with claim 1 wherein said molecule shows mass numbers of 1899, 1866, 1809, 1290, 1200, 609, 591, 219 and 149 according to fast atom bombardment mass spectroscopy.
Claim 4
Dependent Claim
21 words
A drug in accordance with claim 2 wherein said mixture is in liquid form having a concentration of approximately 2.5 mg/cc.
Claim 5
Dependent Claim
23 words
A drug in accordance with claim 3 wherein said liquid form includes isotonic saline solution at a pH of approximately 7.0 to 7.2.
Claim 6
Dependent Claim
14 words
A drug in accordance with claim 4 wherein the mixture is orange-red in color.
Claim 7
Dependent Claim
71 words
A process for the production and purification of the drug defined in claim 1, which comprises, reacting hematoporphyrin with acetic/sulfuric acids to form a solution, precipitating the crude product by neutralization in sodium acetate, dissolving the crude product with sodium hydroxide, adjusting the acidity of the solution to pH of 9.5 and passing the resultant impure solution through a porous membrane system to exclude low molecular weight by-products thereby effecting purification.
Claim 8
Dependent Claim
28 words
A process in accordance with claim 6 including adding sodium chloride to said impure solution to make the latter isotonic prior to passing it through said membrane system.
Claim 9
Dependent Claim
35 words
A process in accordance with claim 7 wherein a solution of said drug is prepared with a concentration of approximately 2.5 mg/cc and is adjusted to obtain said concentration by addition or removal of liquid.