US4627419A
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US
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Blood pump apparatus and method
Assignee: The University of Texas System
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Filing: 1984-08-29
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Granted: 1986-12-09
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Expires: 2004-08-29
Abstract
Abstract A blood pump apparatus and method for pumping blood and pressure treating blood for minimizing hemolysis, platelet degradation, microthrombus and bubble formation. A blood pump apparatus for pumping and pressure treating blood comprising a flaccid chamber having an inlet for accepting fluid and an outlet for expelling fluid, a pressure housing associated with the flaccid chamber for applying pressure isotropically to dissolve or crush gaseous bubbles in the blood, an inert, heavier than blood, immiscible fluid acceptable in said flaccid chamber for displacing blood from said flaccid chamber and for drawing blood into said flaccid chamber, means for displacing said flaccid chamber and a hydraulic system and associated valves for controlling the flow of the inert fluid. A method for pumping and pressure treating blood comprising the steps of pumping an inert, heavier than blood, immiscible fluid into a flaccid chamber, inverting the flaccid chamber to position the chamber outlet below the chamber inlet for the fluid to and egrass the flaccid chamber thereby causing the blood to ingress the flaccid chamber, isotropically applying sufficient pressure for a sufficient time to dissolve or crush gaseous bubbles in the blood, ceasing the application of the pressure to the flaccid chamber, inverting the flaccid chamber to position the chamber inlet below the chamber outlet and pumping the inert fluid into the flaccid chamber thereby purging the blood from the flaccid chamber.
Inventors
- 👤 Brian A. Hills
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 00:34
CPC Classifications
A; A61; A61M; A61M60/00; A61M60/40; A61M60/424; A61M60/427; A61M60/435; A61M60/10; A61M60/104; A61M60/109; A61M60/113; A61M60/30; A61M60/36; A61M60/38; A61M60/80; A61M60/845; A61M60/849; A61M60/851; A61M60/855; A61M60/89; A61M60/892; A61M60/894; Y; Y10; Y10S; Y10S128/00; Y10S128/12
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
99 words
Apparatus for the pressure treatment of blood comprising: (a) a flaccid chamber having an interior surface, exterior surface, an inlet for accepting blood, an outlet for expelling blood; (b) a pressure housing including pressure applying means for applying pressure isotropically to blood in said flaccid chamber; (c) means for introducing a physiologically inert fluid which is heavier than and immiscible with blood into said flaccid chamber so as to displace blood from said flaccid chamber; and (d) means for rotating said flaccid chamber in order to change the orientation of the inlet and outlet with respect to one another.
Claim 2
Dependent Claim
99 words
Apparatus for the pressure treatment of blood comprising: (a) a flaccid chamber having an interior surface, exterior surface, an inlet for accepting blood, an outlet for expelling blood; (b) a pressure housing including pressure applying means for applying pressure isotropically to blood in said flaccid chamber; (c) means for introducing a physiologically inert fluid which is heavier than and immiscible with blood into said flaccid chamber so as to displace blood from said flaccid chamber; and (d) means for rotating said flaccid chamber in order to change the orientation of the inlet and outlet with respect to one another.
Claim 3
Dependent Claim
42 words
An apparatus as defined in claim 1 further comprising a valve associated with the inlet of said flaccid chamber and a valve associated with the outlet of said flaccid chamber for controlling the flow of blood to and from said flaccid chamber.
Claim 4
Dependent Claim
39 words
An apparatus as defined in claim 2 wherein said valves are encompassed by said pressure housing for preventing pressure differentials on said valves thereby preventing said valves from leaking during the application of isotropic pressure by said pressure housing.
Claim 5
Dependent Claim
24 words
An apparatus as defined in claim 1 wherein the isotropic pressure comprises between about 50 to about 1,000 pounds per square inch of pressure.
Claim 6
Dependent Claim
21 words
An apparatus as defined in claim 4 wherein the time duration of the isotropic pressure comprises approximately 1 to 30 seconds.
Claim 7
Dependent Claim
27 words
An apparatus as defined in claim 3 wherein said pressure housing further comprises a gas for transferring an isotropic pressure to the blood within said flaccid chamber.
Claim 8
Dependent Claim
42 words
An apparatus as defined in claim 6 wherein the circulating temperature of said gas corresponds to the temperature of the blood of the patient for maintaining the temperature of the pumped blood at the same temperature as the blood of the patient.
Claim 9
Dependent Claim
13 words
An apparatus as defined in claim 2 wherein said valves comprise ball valves.
Claim 10
Dependent Claim
41 words
An apparatus as defined in claim 1 wherein the interior surface of said flaccid chamber has such an affinity for said inert fluid to further comprise a liquid film of said inert fluid on the interior surface of said flaccid chamber.
Claim 11
Dependent Claim
69 words
An apparatus as defined in claim 1 wherein the interior surface of said flaccid chamber and all related interior components are covered with a synthetic fluorocarbon and said inert fluid comprises a fluorocarbon, such that a liquid film of the fluorocarbon is maintained on the interior surface of said flaccid chamber thereby preventing the direct contact of blood with the interior surface, minimizing blood trauma and reducing microthrombus formations.
Claim 12
Dependent Claim
16 words
An apparatus as defined in claim 1 wherein said flaccid chamber is a unitary single-use unit.
Claim 13
Independent Claim
90 words
A method for pumping blood comprising the steps of: closing a blood outlet valve in fluid communication with a flexible chamber when said outlet valve is in contact with an inert fluid that is immiscible with blood; inletting blood into said flexible chamber through an inlet valve; filling the inlet valve with said inert fluid; closing said blood inlet valve when said inlet valve is in contact with said inert fluid; and displacing said blood from said chamber through said outlet valve by pumping said inert fluid into said chamber.
Claim 14
Independent Claim
90 words
A method for pumping blood comprising the steps of: closing a blood outlet valve in fluid communication with a flexible chamber when said outlet valve is in contact with an inert fluid that is immiscible with blood; inletting blood into said flexible chamber through an inlet valve; filling the inlet valve with said inert fluid; closing said blood inlet valve when said inlet valve is in contact with said inert fluid; and displacing said blood from said chamber through said outlet valve by pumping said inert fluid into said chamber.
Claim 15
Dependent Claim
26 words
The method of claim 12 including the step of rotating said inlet and outlet valves to position the valve to be closed below the other valve.
Claim 16
Dependent Claim
19 words
The method of claim 12 including the step of applying an isotropic pressure to said blood in said chamber.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-12-08 | 1990-06-09 | 1990-12-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-12-08 | 1994-06-09 | 1994-12-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-12-08 | 1998-06-09 | 1998-12-09 | $7700.00 | Window Closed / Lapsed |