US4622362A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polyacrolein microspheres
Assignee: California Institute of Technology
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Filing: 1983-08-04
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Granted: 1986-11-11
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Expires: 2003-08-04
Abstract
Abstract Microspheres of acrolein homopolymers and copolymer with hydrophillic comonomers such as methacrylic acid and/or hydroxyethylmethacrylate are prepared by cobalt gamma irradiation of dilute aqueous solutions of the monomers in presence of suspending agents, especially alkyl sulfates such as sodium dodecyl sulfate. Amine or hydroxyl modification is achieved by forming adducts with diamines or alkanol amines. Carboxyl modification is effected by oxidation with peroxides. Pharmaceuticals or other aldehyde reactive materials can be coupled to the microspheres. The microspheres directly form antibody adducts without agglomeration.
Inventors
- 👤 Alan Rembaum
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:25
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/51; A61K9/5107; A61K9/513; A61K9/5138; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58; C; C08; C08F; C08F16/00; C08F16/34; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54313; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
70 words
A composition comprising the adduct of an aldehyde reactive material selected from proteins, pharmaceuticals and fluorescent chromophores with a microsphere of the addition interpolymerizate of a monomer mixture containing: 20 to 90 percent by weight of an addition polymerizable unsaturated aldehyde selected from acrolein and C 1 to C 8 aryl, alkyl or cycloalkyl derivatives thereof; and 0.1 to 20 percent by weight of an addition copolymerizable, polyunsaturated cross-linking agent.
Claim 2
Dependent Claim
70 words
A composition comprising the adduct of an aldehyde reactive material selected from proteins, pharmaceuticals and fluorescent chromophores with a microsphere of the addition interpolymerizate of a monomer mixture containing: 20 to 90 percent by weight of an addition polymerizable unsaturated aldehyde selected from acrolein and C 1 to C 8 aryl, alkyl or cycloalkyl derivatives thereof; and 0.1 to 20 percent by weight of an addition copolymerizable, polyunsaturated cross-linking agent.
Claim 3
Dependent Claim
41 words
A composition according to claim 1 in which the interpolymerizate further contains 10 to 50 percent by weight of at least one addition copolymerizable, mono-unsaturated, freely water soluble acrylic comonomer substituted with a hydrophilic substituent selected from amine, carboxyl or hydroxyl.
Claim 4
Dependent Claim
21 words
A composition according to claim 1 in the form of small microspheres having a diameter from 500 Angstroms to 10 microns.
Claim 5
Dependent Claim
17 words
A composition according to claim 3 in which the diameter is from 100 Angstroms to 2000 Angstroms.
Claim 6
Dependent Claim
12 words
A composition according to claim 1 in which the aldehyde is acrolein.
Claim 7
Dependent Claim
16 words
A composition according to claim 5 in which the pharmaceutical is an amine substituted chemotherapeutic agent.
Claim 8
Dependent Claim
23 words
A composition according to claim 1 in which the aldehyde is selected from acrolein, methacrolein, alpha-ethyl acrolein, alpha-butylacrolein, alpha-chloroacrolein, beta-phenylacrolein, alpha-cyclohexylacrolein and alpha-decylacrolein.
Claim 9
Dependent Claim
40 words
A composition according to claim 7 in which the cross-linking agent is present in an amount from 6 to 12% by weight and is selected from a polyvinyl diene or triene capable of addition polymerization with the covalent bonding monomer.
Claim 10
Dependent Claim
23 words
A composition according to claim 7 in which the copolymer further includes 0.05% to 5% by weight of a copolymerizable fluorescent chromophore monomer.
Claim 11
Dependent Claim
16 words
A composition according to claim 1 in which the proteins are selected from antibodies or enzymes.
Claim 12
Dependent Claim
16 words
A composition according to claim 7 in which the microspheres contain a dispersion of magnetic particles.
References Cited (Backward Citations)
US4267234A
Cited
US4424302A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-11-10 | 1990-05-12 | 1990-11-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-11-10 | 1994-05-12 | 1994-11-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-11-10 | 1998-05-12 | 1998-11-11 | $7700.00 | Window Closed / Lapsed |