US4612304A
Expired / Lapsed
US
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Antitumor formulation containing lipopolysaccharide with trehalose derivatives
Assignee: SSP Co Ltd
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Filing: 1985-06-11
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Granted: 1986-09-16
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Expires: 2005-06-11
Abstract
Abstract Disclosed herein is an antitumor formulation, which contains an alpha , alpha -trehalose-6,6'-dicarboxylate, which is represented by the following general formula (I): <IMAGE> (I) wherein R means a C1-C21 alkyl group, and a lipopolysaccharide. The antitumor formulation features low toxicity and high antitumor activities.
Inventors
- 👤 Kazue Fukushi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:50
CPC Classifications
C; C07; C07H; C07H13/00; C07H13/02; C07H13/04; C07H13/06; A; A61; A61K; A61K31/00; A61K31/70; A61K31/715
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
42 words
An antitumor formulation comprising an α,α-trehalose-6,6'-dicarboxylate, which is represented by the following general formula (I): ##STR4## wherein R represents a C 1 -C 21 alkyl group, and a lipopolysaccharide, the ratio of compound I to the lipopolysaccharide ranging from 10:1 to 1:10.
Claim 2
Dependent Claim
42 words
An antitumor formulation comprising an α,α-trehalose-6,6'-dicarboxylate, which is represented by the following general formula (I): ##STR4## wherein R represents a C 1 -C 21 alkyl group, and a lipopolysaccharide, the ratio of compound I to the lipopolysaccharide ranging from 10:1 to 1:10.
Claim 3
Dependent Claim
20 words
An antitumor formulation as claimed in claim 1, wherein the lipopolysaccharide is previously treated with alkali to attenuate its toxicity.
Claim 4
Dependent Claim
16 words
An antitumor formulation as claimed in claim 1, wherein the ratio ranges from 2:1 to 1:4.
Claim 5
Dependent Claim
18 words
An antitumor formulation as claimed in claim 1, wherein R represents a C 8 -C 10 alkyl group.
Claim 6
Dependent Claim
13 words
An antitumor formulation as claimed in claim 4, wherein compound I is α,α-trehalose-6,6'-dioctanoate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-09-15 | 1990-03-17 | 1990-09-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-09-15 | 1994-03-17 | 1994-09-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-09-15 | 1998-03-17 | 1998-09-16 | $7700.00 | Window Closed / Lapsed |