Abstract An antiviral drug contains as its effective component an isothiosemicarbazone represented by the following general formula (I) or an acidic salt thereof: ##STR1## wherein R 1 represents a halogen atom, a lower (C 1 -C 6 ) alkyl group, a hydroxy group, a phenyl group which may be or may not be substituted with an alkoxy group containing 1 to 12 carbon atoms, or an unsubstituted or substituted phenylethynyl group represented by the following general formula (II): ##STR2## (wherein R 5 and R 6 may be the same or different, and they each represent a hydrogen atom, a halogen atom, a lower (C 1 -C 6 ) alkyl group, a hydroxy group or an alkoxy group containing 1 to 12 carbon atoms); R 2 represents a hydrogen atom or a lower (C 1 -C 6 ) alkyl group; R 3 represents a lower (C 1 -C 6 ) alkyl group or a benzyl group; R 4 represents a hydrogen atom or a lower (C 1 -C 6 ) alkyl group. Many of these effective component compounds not only have antiviral activity (especially against influenza virus), but also prevent the breeding of and exterminate plant pathogenic molds.
A process for treating a subject having an A 2 -type influenza virus infection which comprises administering orally or by injection an anti A 2 -type influenza viral effective amount of an isothiosemicarbazone represented by the following general formula (I) or an acidic salt thereof: ##STR60## wherein R 1 represents an unsubstituted phenyl group or a phenyl group substituted by at least one of 1 to 3 halogen atoms selected from the group consisting of fluorine, chlorine and bromine, a methyl group substituted in the para position of the phenyl group, a hydroxyl group, or an alkoxy group containing 1 to 12 carbon atoms substituted in the para position of the phenyl group, or an unsubstituted or substituted phenylethynyl group represented by the following general formula (II) ##STR61## wherein R 5 represents a chlorine atom, or an alkoxy group containing 1 to 12 carbon atoms; R 2 represents a hydrogen atom or a C 1 -C 6 alkyl group; and R 3 represents a C 1 -C 6 alkyl group; and R 4 represents a hydrogen atom or a methyl group, to said subject.
Claim 2
Dependent Claim
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A process for treating a subject having an A 2 -type influenza virus infection which comprises administering orally or by injection an anti A 2 -type influenza viral effective amount of an isothiosemicarbazone represented by the following general formula (I) or an acidic salt thereof: ##STR60## wherein R 1 represents an unsubstituted phenyl group or a phenyl group substituted by at least one of 1 to 3 halogen atoms selected from the group consisting of fluorine, chlorine and bromine, a methyl group substituted in the para position of the phenyl group, a hydroxyl group, or an alkoxy group containing 1 to 12 carbon atoms substituted in the para position of the phenyl group, or an unsubstituted or substituted phenylethynyl group represented by the following general formula (II) ##STR61## wherein R 5 represents a chlorine atom, or an alkoxy group containing 1 to 12 carbon atoms; R 2 represents a hydrogen atom or a C 1 -C 6 alkyl group; and R 3 represents a C 1 -C 6 alkyl group; and R 4 represents a hydrogen atom or a methyl group, to said subject.
Claim 3
Dependent Claim
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The process of claim 1 wherein said phenyl group is substituted in the para-position.
Claim 4
Dependent Claim
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The process of claim 2 wherein said phenyl group is substituted by a halogen atom in the para-position.
Claim 5
Dependent Claim
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The process of claim 2 wherein said phenyl group is substituted by said alkoxy group in the para-position.
Claim 6
Dependent Claim
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The process of claim 1 wherein said isothiosemicarbazone is selected from the group consisting of ##STR62##