Thrombin inhibitory new dihydroxybenzene ether derivatives

Abstract

Abstract An ether derivative of a dihydroxybenzene of the formula ##STR1## in which R 1 is 1 to 3 identical or different substituents selected from hydrogen, halogen, trifluoromethyl, carboxyl, alkyl, alkoxy, alkylmercapto and carbalkoxy, with in each case 1 to 4 carbon atoms in the alkyl and alkoxy groups, and R 2 and R 3 are different and each is an alkyl or alkenyl chain in which 1 or 2 CH 2 chain members are optionally replaced by O, S, CO or a phenylene group, and/or in which the chain is optionally substituted by 1 to 3 identical or different substituents selected from hydroxyl, halogen, trifluoromethyl, phenyl, carboxyl, alkyl, alkoxy, alkylmercapto, carbalkoxy, and acyl, the phenyl radical in turn optionally being substituted by halogen, trifluoromethyl, carboxyl, alkyl, alkoxy, alkylmercapto or carbaloxy, and the abovementioned alkyl, alkoxy and acyl groups in each case containing 1 to 4 carbon atoms, and in which at least one of the radicals R 2 or R 3 is substituted and/or in at least one of the radicals R 2 or R 3 1 or 2 chain members are replaced by 1 or 2 identical or different radicals selected from O, S, CO and phenylene, is effective in combating cardiac infarcations, angina pectoric, thromboembolic illnesses, in venous and arterial regions and arteriosclerosis.

Inventors

• 👤 Horst Boshagen
• 👤 Ulrich Horlein
• 👤 Gerd Reinhardt
• 👤 Friedel Seuter
• 👤 Elisabeth Perzborn

Bibliographic Details