Closed drug delivery system

Claim 2

A closed drug delivery system which comprises: a flexible container having a liquid diluent therein, said flexible container having a delivery outlet; a capsule including a relatively rigid wall coupled to said flexible container, said capsule having means for supporting a drug vial and flexible means for enabling movement of the drug vial relative to the supporting means; a drug vial having a drug therein adapted to be mixed with said diluent, said drug vial being supported by said supporting means and being adapted for engagement by said flexible means; means coupling said capsule to the interior of said flexible container, said coupling means including means for communicating with the interior of the drug vial, said communicating means being out of communication with the interior of the drug vial when the vial is in a first position supported by said supporting means, said communicating means being in communication with the interior of the drug vial when the vial has been moved relative to said supporting means and the vial is in another position within said capsule.

Claim 3

A system as described in claim 1, said flexible container comprising a sealed vinyl container and said delivery outlet is at a lowest location of the container.

Claim 4

A system as described in claim 1, said capsule having a relatively rigid bottom and side walls, and said flexible means comprising a flexible member that is sealed at the top of the side walls, said flexible member being substantially deformable to enable manual downward movement thereof.

Claim 5

A system as described in claim 3, said flexible member including a plurality of pleats surrounding a planar central portion, with the flexible member being sealed to the side walls adjacent the periphery of the flexible member.

Claim 6

A system as described in claim 3, said flexible member having a generally circular outline and said capsule carrying means for enabling hanging of the capsule.

Claim 7

A system as described in claim 1, said capsule having side walls formed in a generally circular configuration, and said flexible means comprising a generally circular flexible member sealed at the top of the side walls and being substantially deformable to enable manual downward movement thereof.

Claim 8

A system as described in claim 6, said flexible member including a plurality of pleats surrounding a planar central portion, with the flexible member being sealed to the side walls adjacent the periphery of the flexible member.

Claim 9

A system as described in claim 1, said drug vial comprising a standard glass drug vial bottle having a pierceable stopper retained by a metal band, said communicating means comprising a spike for piercing said stopper when the vial is moved onto the spike.

Claim 10

A system as described in claim 1, said drug vial having a pierceable stopper, said communicating means comprising a spike for piercing said stopper when the vial is moved onto the spike.

Claim 11

A system as described in claim 1, said capsule having a bottom and side walls with said supporting means comprising a plurality of legs extending inwardly from the capsule.

Claim 12

A system as described in claim 10, said legs extending upwardly from the bottom of the capsule.

Claim 13

A system as described in claim 10, said legs extending radially inwardly from the side walls of the capsule.

Claim 14

A system as described in claim 1, said coupling means including a frangible member preventing fluid flow unless the frangible member is broken.

Claim 15

A system as described in claim 1, said capsule comprising a relatively rigid plastic housing and said flexible means comprising a plastic bellows cap sealingly covering the plastic housing, the plastic bellows cap being substantially deformable to enable manual downward movement thereof.

Claim 16

A system as described in claim 1, said flexible container, said capsule, and said coupling means having sterile interiors whereby the drug delivery system is sterile.

Claim 17

A closed drug delivery system which comprises: a flexible container having a liquid diluent therein, said flexible container having a delivery outlet; said flexible container comprising a sealed vinyl container and said delivery outlet being at a lowest location of the container; a capsule coupled to said flexible container, said capsule having means for supporting a drug vial and flexible means for enabling movement of the drug vial relative to the supporting means; said capsule having a relatively rigid bottom and side walls, and said flexible means comprising a flexible member that is sealed at the top of the side walls, said flexible member being substantially deformable to enable manual downward movement thereof; said flexible member including a plurality of pleats surrounding a planar central portion, with the flexible member being sealed to the side walls adjacent the periphery of the flexible member; said flexible member having a generally circular outline and said capsule carrying means for enabling hanging of the capsule; a drug vial having a drug therein adapted to be mixed with said diluent, said drug vial being supported by said supporting means and being adapted for engagement by said flexible member; means coupling said capsule to the interior of said flexible container, said coupling means including means for communicating with the interior of the drug vial, said communicating means being out of communication with the interior of the vial when the vial is in a first position supported by said supporting means, said communicating means being in communication with the interior of the vial when the vial has been moved relative to said supporting means and the vial is in another position within said capsule; said drug vial having a pierceable stopper, said communicating means comprising a spike for piercing said stopper when the vial is moved onto the spike; said supporting means comprising a plurality of legs extending inwardly from the capsule; and said coupling means including a frangible member preventing fluid flow unless the frangible member is broken.

Claim 18

A closed drug delivery system which comprises: a flexible container having a liquid diluent therein, said flexible container having a delivery outlet; said flexible container comprising a sealed vinyl container and said delivery outlet being at a lowest location of the container; a capsule coupled to said flexible container, said capsule having means for supporting a drug vial and flexible means for enabling movement of the drug vial relative to the supporting means; said capsule having a relatively rigid bottom and side walls, and said flexible means comprising a flexible member that is sealed at the top of the side walls, said flexible member being substantially deformable to enable manual downward movement thereof; said flexible member including a plurality of pleats surrounding a planar central portion, with the flexible member being sealed to the side walls adjacent the periphery of the flexible member; said flexible member having a generally circular outline and said capsule carrying means for enabling hanging of the capsule; a drug vial having a drug therein adapted to be mixed with said diluent, said drug vial being supported by said supporting means and being adapted for engagement by said flexible member; means coupling said capsule to the interior of said flexible container, said coupling means including means for communicating with the interior of the drug vial, said communicating means being out of communication with the interior of the vial when the vial is in a first position supported by said supporting means, said communicating means being in communication with the interior of the vial when the vial has been moved relative to said supporting means and the vial is in another position within said capsule; said drug vial having a pierceable stopper, said communicating means comprising a spike for piercing said stopper when the vial is moved onto the spike; said supporting means comprising a plurality of legs extending inwardly from the capsule; and said coupling means including a frangible member preventing fluid flow unless the frangible member is broken.

Claim 19

A drug delivery system which comprises: a flexible container having a liquid diluent therein; a capsule including a relatively rigid wall coupled to said flexible container, said capsule having means for supporting a drug vial and flexible means for enabling movement of the drug vial relative to the supporting means; means coupling said capsule to the interior of said flexible container, said coupling means including means for communicating with the interior of the drug vial, said communicating means being out of communication with the interior of the vial when the vial is in a first position supported by said supporting means, said communicating means being in communication with the interior of the vial when the vial has been moved relative to said supporting means and the vial is in another position within said capsule.

Claim 20

A drug delivery system which comprises: a flexible container having a liquid diluent therein; a capsule including a relatively rigid wall coupled to said flexible container, said capsule having means for supporting a drug vial and flexible means for enabling movement of the drug vial relative to the supporting means; means coupling said capsule to the interior of said flexible container, said coupling means including means for communicating with the interior of the drug vial, said communicating means being out of communication with the interior of the vial when the vial is in a first position supported by said supporting means, said communicating means being in communication with the interior of the vial when the vial has been moved relative to said supporting means and the vial is in another position within said capsule.

Claim 21

A system as described in claim 17, said flexible container comprising a sealed vinyl container having a delivery outlet at a lowest location of the container.

Claim 22

A system as described in claim 17, said capsule having a relatively rigid bottom and side walls, and said flexible means comprising a flexible member that is sealed at the top of the side walls, said flexible means being substantially deformable to enable manual downward movement thereof.

Claim 23

A system as described in claim 19, said flexible member including a plurality of pleats surrounding a planar central portion, with the flexible member being sealed to the side walls adjacent the periphery of the flexible member.

Claim 24

A system as described in claim 20, said flexible member having a generally circular outline and said capsule carrying means for enabling hanging of the capsule.

Claim 25

A system as described in claim 17, said capsule having side walls formed in a generally circular configuration, and said flexible means comprising a generally circular flexible member sealed at the top of the side walls and being substantially deformable to enable manual downward movement thereof.

Claim 26

A system as described in claim 17, including a drug vial having a drug therein adapted to be mixed with said diluent, said drug vial being supported by said supporting means and being adapted for engagement by said flexible means, said drug vial comprising a standard glass drug vial bottle having a pierceable stopper retained by a metal band, said communicating means comprising a spike for piercing said stopper when the vial is moved onto the spike.

Claim 27

A system as described in claim 17, including a drug vial having a drug therein adapted to be mixed with said diluent, said drug vial being supported by said supporting means and being adapted for engagement by said flexible means, said drug vial having a pierceable stopper, said communicating means comprising a spike for piercing said stopper when the vial is moved onto the spike.

Claim 28

A system as described in claim 17, said capsule having a bottom and side walls with said supporting means comprising a plurality of legs extending inwardly from the capsule.

Claim 29

A system as described in claim 17, said coupling means including a frangible member preventing fluid flow unless the frangible member is broken.

Claim 30

A system as described in claim 17, said capsule comprising a relatively rigid plastic housing and said flexible means comprising a plastic bellows cap sealingly covering the plastic housing, the plastic bellows cap being substantially deformable to enable manual downward movement thereof.

Claim 31

A drug delivery system which comprises: a flexible container having a liquid diluent therein; a capsule including a relatively rigid wall, coupled to said flexible container, said capsule having means for supporting a drug vial and flexible means for enabling movement of the drug vial relative to the supporting means, said flexible means including a flexible member having a plurality of pleats surrounding a planar central portion, with the flexible member being sealed to said wall adjacent the periphery of the flexible member, said flexible member being substantially deformable to enable manual downward movement thereof; means coupling said capsule to the interior of said flexible container, said coupling means including means for communicating with the interior of the drug vial, said communicating means being out of communication with the interior of the vial when the vial is in a first position supported by said supporting means, said communicating means being in communication with the interior of the vial when the vial has been moved relative to said supporting means and the vial is in another position within said capsule.

Claim 32

A drug delivery system which comprises: a flexible container having a liquid diluent therein; a capsule including a relatively rigid wall, coupled to said flexible container, said capsule having means for supporting a drug vial and flexible means for enabling movement of the drug vial relative to the supporting means, said flexible means including a flexible member having a plurality of pleats surrounding a planar central portion, with the flexible member being sealed to said wall adjacent the periphery of the flexible member, said flexible member being substantially deformable to enable manual downward movement thereof; means coupling said capsule to the interior of said flexible container, said coupling means including means for communicating with the interior of the drug vial, said communicating means being out of communication with the interior of the vial when the vial is in a first position supported by said supporting means, said communicating means being in communication with the interior of the vial when the vial has been moved relative to said supporting means and the vial is in another position within said capsule.

Claim 33

A drug delivery system which comprises: a flexible container having a liquid diluent therein; a capsule having side walls formed in a generally circular configuration, coupled to said flexible container, said capsule having means for supporting a drug vial and flexible means for enabling movement of the drug vial relative to the supporting means, said flexible means including a generally circular flexible member having a plurality of pleats surrounding a planar central portion, with the flexible member being sealed to the side walls adjacent the periphery of the flexible member; means coupling said capsule to the interior of said flexible container, said coupling means including means for communicating with the interior of the drug vial, said communicating means being out of communication with the interior of the vial when the vial is in a first position supported by said supporting means, said communicating means being in communication with the interior of the vial when the vial has been moved relative to said supporting means and the vial is in another position within said capsule.

Claim 34

A drug delivery system which comprises: a flexible container having a liquid diluent therein; a capsule having side walls formed in a generally circular configuration, coupled to said flexible container, said capsule having means for supporting a drug vial and flexible means for enabling movement of the drug vial relative to the supporting means, said flexible means including a generally circular flexible member having a plurality of pleats surrounding a planar central portion, with the flexible member being sealed to the side walls adjacent the periphery of the flexible member; means coupling said capsule to the interior of said flexible container, said coupling means including means for communicating with the interior of the drug vial, said communicating means being out of communication with the interior of the vial when the vial is in a first position supported by said supporting means, said communicating means being in communication with the interior of the vial when the vial has been moved relative to said supporting means and the vial is in another position within said capsule.

Claim 35

A drug delivery system which comprises: a flexible container having a liquid diluent therein; a capsule coupled to said flexible container, said capsule having means for supporting a drug vial and flexible means for enabling movement of the drug vial relative to the supporting means, said supporting means including a plurality of legs extending inwardly from the capsule; means coupling said capsule to the interior of said flexible container, said coupling means including means for communicating with the interior of the drug vial, said communicating means being out of communication with the interior of the vial when the vial is in a first position supported by said supporting means, said communicating means being in communication with the interior of the vial when the vial has been moved relative to said supporting means and the vial is in another position within said capsule.

Claim 36

A drug delivery system which comprises: a flexible container having a liquid diluent therein; a capsule coupled to said flexible container, said capsule having means for supporting a drug vial and flexible means for enabling movement of the drug vial relative to the supporting means, said supporting means including a plurality of legs extending inwardly from the capsule; means coupling said capsule to the interior of said flexible container, said coupling means including means for communicating with the interior of the drug vial, said communicating means being out of communication with the interior of the vial when the vial is in a first position supported by said supporting means, said communicating means being in communication with the interior of the vial when the vial has been moved relative to said supporting means and the vial is in another position within said capsule.

Claim 37

A system as described in claim 30, said capsule further comprising a bottom and side walls.

Claim 38

A system as described in claim 31, said legs extending upwardly from the bottom of the capsule.

Claim 39

A system as described in claim 31, said legs extending radially inwardly from the side walls of the capsule.

Claim 40

A drug delivery system which comprises: a flexible container having a liquid diluent therein; a capsule including a relatively rigid housing, coupled to said flexible container, said capsule having means for supporting a drug vial and flexible means for enabling movement of the drug vial relative to the supporting means, said flexible means including a plastic bellows cap sealingly covering the housing, the plastic bellows cap being substantially deformable to enable manual downward movement thereof; means coupling said capsule to the interior of said flexible container, said coupling means including means for communicating with the interior of the drug vial, said communicating means being out of communication with the interior of the vial when the vial is in a first position supported by said supporting means, said communicating means being in communication with the interior of the vial when the vial has been moved relative to said supporting means and the vial is in another position within said capsule.

Claim 41

A drug delivery system which comprises: a flexible container having a liquid diluent therein; a capsule including a relatively rigid housing, coupled to said flexible container, said capsule having means for supporting a drug vial and flexible means for enabling movement of the drug vial relative to the supporting means, said flexible means including a plastic bellows cap sealingly covering the housing, the plastic bellows cap being substantially deformable to enable manual downward movement thereof; means coupling said capsule to the interior of said flexible container, said coupling means including means for communicating with the interior of the drug vial, said communicating means being out of communication with the interior of the vial when the vial is in a first position supported by said supporting means, said communicating means being in communication with the interior of the vial when the vial has been moved relative to said supporting means and the vial is in another position within said capsule.

Claim 42

A system as described in claim 28, further comprising a drug vial having a drug therein adapted to be mixed with said diluent, said drug vial being supported by said supporting means and being adapted for engagement by said flexible means.

Claim 43

A system as described in claim 29, further comprising a drug vial having a drug therein adapted to be mixed with said diluent, said drug vial being supported by said supporting means and being adapted for engagement by said flexible means.

Claim 44

A system as described in claim 30, further comprising a drug vial having a drug therein adapted to be mixed with said diluent, said drug vial being supported by said supporting means and being adapted for engagement by said flexible means.

Claim 45

A system as described in claim 34, further comprising a drug vial having a drug therein adapted to be mixed with said diluent, said drug vial being supported by said supporting means and being adapted for engagement by said flexible means.