US4534825A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of making an electrochemical sensing cell
Assignee: Cordis Europa NV
•
Filing: 1984-03-09
•
Granted: 1985-08-13
•
Expires: 2004-03-09
Abstract
Abstract An in vivo electrochemical monitoring device is formed by a catheter-like member which terminates in a closed end having a wall with a fixed opening to admit fluid to be tested, such as blood in an artery. An electrochemical sensor, such as an ISFET device for monitoring the concentration of a particular ion in blood, is mounted inside the tube at a fixed location below the opening preferably a larger sensing chamber. An infusion channel in the tube is arranged to flood the sensor with a fluid of known chemical properties so that the sensor output can be calibrated. Under pressure the calibration fluid expels the test fluid out of the tube or chamber via the fixed opening. A method of constructing a suitable chamber on an ISFET wafer is also disclosed.
Inventors
- 👤 Gerrit Koning
- 👤 Piet Bergveld
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:25
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/14542; A61B5/1468; A61B5/1473; A61B5/1495; G; G01; G01N; G01N27/00; G01N27/26; G01N27/28; G01N27/416; G01N27/4163; G01N27/4165
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
137 words
A method of making a sensing cell for a chemically sensitive probe for measuring the properties of biological fluids in vivo, comprising the steps of producing a wafer comprising an ISFET with spaced source and drain regions spanned by an ion-sensitive gate portion, covering said source and drain regions and gate portion of said ISFET with a temporary first layer of soluble material, covering said temporary first layer with a second layer of relatively insoluble material, defining an opening in said second layer directly above said gate region, and removing said temporary first layer which covers the source and drain regions and the gate portion by introducing a solvent through said opening to dissolve said first layer, thus forming a sensing chamber encompassing the source and drain regions as well as the gate portion of said ISFET.
Claim 2
Independent Claim
137 words
A method of making a sensing cell for a chemically sensitive probe for measuring the properties of biological fluids in vivo, comprising the steps of producing a wafer comprising an ISFET with spaced source and drain regions spanned by an ion-sensitive gate portion, covering said source and drain regions and gate portion of said ISFET with a temporary first layer of soluble material, covering said temporary first layer with a second layer of relatively insoluble material, defining an opening in said second layer directly above said gate region, and removing said temporary first layer which covers the source and drain regions and the gate portion by introducing a solvent through said opening to dissolve said first layer, thus forming a sensing chamber encompassing the source and drain regions as well as the gate portion of said ISFET.
Claim 3
Dependent Claim
12 words
The method of claim 1, wherein said second layer is electrically conductive.
Claim 4
Dependent Claim
39 words
The method of claim 1, further comprising the step of forming an infusion through-hole through the wafer leading into said sensing chamber, whereby a known fluid can be introduced through said through-hole into said chamber for calibration in vivo.
Claim 5
Dependent Claim
24 words
The method of claim 1, wherein said opening formed in said second layer is narrower than said chamber formed by removing said first layer.
Claim 6
Dependent Claim
22 words
The method of claim 1, further comprising the step of covering said cell with a layer of hydrogel to promote biological compatability.
References Cited (Backward Citations)
US3476670A
Cited
US3924321A
Cited
US4020830A
Cited
US4020830B1
Cited
US4041933A
Cited
US4152233A
Cited
US4221567A
Cited
EP0015075A1
Cited
EP0036171A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-08-12 | 1989-02-11 | 1989-08-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-08-12 | 1993-02-11 | 1993-08-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-08-12 | 1997-02-11 | 1997-08-13 | $7700.00 | Window Closed / Lapsed |