Patent US1498399A successfully refreshed from Google Patents.
US4534356A
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US
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Solid state transcutaneous blood gas sensors
Assignee: Biospecific Technologies Inc
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Filing: 1982-07-30
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Granted: 1985-08-13
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Expires: 2002-07-30
Abstract
Abstract Disclosed is a solid state oxygen sensor utilizing a noble metal first electrode and a silver/silver halide reference electrode and an oxygen permeable polymeric membrane electrolyte. Also disclosed is a method of producing said sensor and a method of using said sensor.
Inventors
- 👤 Nicholas Papadakis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 06:42
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/14542; A61B5/1468; A61B5/1477; G; G01; G01N; G01N27/00; G01N27/26; G01N27/403; G01N27/404; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/4925
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
130 words
A solid state transcutaneous oxygen sensor comprising: (a) an electrically insulating substrate; (b) a first electrode comprising a noble metal on said substrate of (a); (c) a second electrode comprising a silver/silver halide reference electrode on said substrate of (a); (d) an insulating dielectric layer on said components (a), (b) and (c) characterized in that at least a portion of component (b) and component (c) remains exposed; and (e) an oxygen permeable polymeric membrane containing a bound liquid electrolyte over at least said exposed portion of said first and said second electrodes; (f) a polymeric oxygen permeable, liquid impermeable, biocompatible membrane coating over said oxygen permeable polymeric membrane containing a bound liquid electrolyte; further characterized in that said exposed portions of said first and second electrodes have well-defined surface areas.
Claim 2
Dependent Claim
130 words
A solid state transcutaneous oxygen sensor comprising: (a) an electrically insulating substrate; (b) a first electrode comprising a noble metal on said substrate of (a); (c) a second electrode comprising a silver/silver halide reference electrode on said substrate of (a); (d) an insulating dielectric layer on said components (a), (b) and (c) characterized in that at least a portion of component (b) and component (c) remains exposed; and (e) an oxygen permeable polymeric membrane containing a bound liquid electrolyte over at least said exposed portion of said first and said second electrodes; (f) a polymeric oxygen permeable, liquid impermeable, biocompatible membrane coating over said oxygen permeable polymeric membrane containing a bound liquid electrolyte; further characterized in that said exposed portions of said first and second electrodes have well-defined surface areas.
Claim 3
Dependent Claim
30 words
A solid state oxygen sensor as claimed in claim 2 wherein said second electrode is selected from the group consisting of silver/silver chloride, silver/silver bromide, silver/silver fluoride, and silver/silver iodide.
Claim 4
Dependent Claim
19 words
A solid state oxygen sensor as claimed in claim 2 wherein said second electrode is composed of silver/silver chloride.
Claim 5
Dependent Claim
29 words
A solid state oxygen sensor as claimed in claim 2 wherein said oxygen permeable membrane, component (e), is selected from the group consisting essentially of hydrogels and hydrophilic polymers.
Claim 6
Dependent Claim
32 words
A solid state oxygen sensor as claimed in claim 4 wherein said hydrogel is selected from the group consisting of homopolymers and copolymers of N-vinyl pyrrolidone, glycidyl methacrylate and hydroxyethyl methacrylate (HEMA).
Claim 7
Dependent Claim
27 words
A solid state oxygen sensor as claimed in claim 2 wherein said component (f) is selected from the group consisting of TEFLON, polyphenylene oxide, polyethylene and polypropylene.
Claim 8
Dependent Claim
35 words
A solid state oxygen sensor as claimed in claim 2 wherein said electrically insulating substrate is selected from the group consisting of ceramic chips, ceramic wafers, ceramic plates, glass chips, glass wafers and glass plates.
Claim 9
Dependent Claim
17 words
A solid state oxygen sensor as claimed in claim 2 wherein said electrically insulating substrate is alumina.
Claim 10
Dependent Claim
27 words
A solid state oxygen sensor as claimed in claim 2 wherein said oxygen permeable polymeric membrane bound liquid electrolyte is an alkali metal halide in a solvent.
Claim 11
Dependent Claim
21 words
A solid state oxygen sensor as claimed in claim 9 wherein said alkali metal halide is NaCl, KCl or mixtures thereof.
Claim 12
Dependent Claim
21 words
A solid state oxygen sensor as claimed in claim 9 wherein said liquid electrolyte is a 0.09 N isotonic saline solution.
Claim 13
Dependent Claim
26 words
A solid state oxygen sensor as claimed in claim 9 wherein said solvent is selected from the group consisting of water, ethylene glycol and mixtures thereof.
Claim 14
Dependent Claim
31 words
A solid state oxygen sensor as claimed in claim 9 wherein said liquid electrolyte comprises 0.1 molar NaCl in a solvent comprising a 1:1 ratio, by weight, water and ethylene glycol.
Claim 15
Dependent Claim
35 words
A solid state oxygen sensor as claimed in claim 2 wherein said noble metal of component (b) is selected from the group consisting of gold, silver, palladium, iridium, rhodium, ruthenium, osmium, platinum and alloys thereof.
Claim 16
Independent Claim
169 words
A method for non-invasively measuring the blood oxygen partial pressure (PO 2 ) of a patient, which method comprises applying a polarization potential to a solid state transcutaneous oxygen sensor comprising: (a) an electrically insulating substrate; (b) a first electrode comprising a noble metal on said substrate of (a); (c) a second electrode comprising a silver/silver halide reference electrode on said substrate of (a); (d) an insulating dielectric layer on said components (a), (b) and (c) characterized in that at least a portion of component (b) and component (c) remains exposed; (e) an oxygen permeable polymeric membrane containing a bound liquid electrolyte over at least said exposed portion of said first and said second electrodes; (f) a polymeric oxygen permeable, liquid impermeable, bicompatible membrane coating over said oxygen permeable polymeric membrane containing a bound liquid electrolyte; and (g) further characterized in that said exposed portions of said first and second electrodes have well-defined surface areas; then contacting the patient's skin with the sensor and measuring the current flow response.
Claim 17
Independent Claim
169 words
A method for non-invasively measuring the blood oxygen partial pressure (PO 2 ) of a patient, which method comprises applying a polarization potential to a solid state transcutaneous oxygen sensor comprising: (a) an electrically insulating substrate; (b) a first electrode comprising a noble metal on said substrate of (a); (c) a second electrode comprising a silver/silver halide reference electrode on said substrate of (a); (d) an insulating dielectric layer on said components (a), (b) and (c) characterized in that at least a portion of component (b) and component (c) remains exposed; (e) an oxygen permeable polymeric membrane containing a bound liquid electrolyte over at least said exposed portion of said first and said second electrodes; (f) a polymeric oxygen permeable, liquid impermeable, bicompatible membrane coating over said oxygen permeable polymeric membrane containing a bound liquid electrolyte; and (g) further characterized in that said exposed portions of said first and second electrodes have well-defined surface areas; then contacting the patient's skin with the sensor and measuring the current flow response.
References Cited (Backward Citations)
US3763850A
Cited
US3912614A
Cited
US3985633A
Cited
US4120770A
Cited
US4296752A
Cited
US4273636A
Cited
GB1581338A
Cited
US4133735A
Cited
US4324257A
Cited
US4324256A
Cited
JPS55101249A
Cited
US4290431A
Cited
US4259963A
Cited
US4265250A
Cited
GB2056689A
Cited
US4269684A
Cited
DE2943958A1
Cited
GB2066962A
Cited
US4340457A
Cited
US4276144A
Cited
US4312332A
Cited
US4409980A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-08-12 | 1989-02-11 | 1989-08-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-08-12 | 1993-02-11 | 1993-08-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-08-12 | 1997-02-11 | 1997-08-13 | $7700.00 | Window Closed / Lapsed |