US4530787B1
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US
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US4530787B1 - - Google Patents
Assignee: Novartis Vaccines and Diagnostics Inc
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Filing: 1984-10-17
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Granted: 1993-07-20
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Expires: 2004-10-17
Abstract
Abstract 57 Method of oxidizing reduced cysteine-containing microbially produced synthetic proteins, such as synthetic INF-β or synthetic IL-2, in a controlled manner so that the synthetic proteins have the same disulfide bridging as their native counterparts. The oxidation employs o-iodosobenzoate as oxidizing agent and is carried out in an aqueous medium at a pH at least about one-half pH unit less than the pK, of the cystines to be oxidized, a synthetic protein concentration of less than about 5 mg ml. and an oxidizing agent:protein mol ratio that is at least stoichiometric, provided that the oxidizing agent is in excess in the terminal portion of the reaction.
Inventors
- 👤 Ev Shaked Ze
- 👤 N Wolfe Sidney
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:49
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/52; C07K14/54; C07K14/55; C07K1/00; C07K1/107; C07K1/113; C07K1/1133; C07K1/14; C07K1/36; C07K14/555; C07K14/565; Y; Y10; Y10S; Y10S435/00; Y10S435/811; Y10S530/00; Y10S530/808; Y10S530/82; Y10S530/825; Y10S930/00; Y10S930/01; Y10S930/14; Y10S930/141; Y10S930/142
Claims Analysis
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References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-07-19 | 1997-01-18 | 1997-07-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-07-19 | 2001-01-18 | 2001-07-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-07-19 | 2005-01-18 | 2005-07-20 | $7700.00 | Window Closed / Lapsed |