US4508657A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Peptide synthesis and amino acid blocking agents
Assignee: Research Corp
•
Filing: 1983-04-29
•
Granted: 1985-04-02
•
Expires: 2003-04-29
Abstract
Abstract Process for the preparation of peptides including higher polypeptides utilizing indenylmethoxycarbonyl blocking groups and products produced thereby.
Inventors
- 👤 Louis A. Carpino
- 👤 Beri Cohen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:19
CPC Classifications
C; C07; C07K; C07K1/00; C07K1/06; C07K1/061; C07K1/063; C07C; C07C29/00; C07C29/132; C07C29/136; C07C29/14; C07C45/00
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
73 words
A compound of the formula ##STR13## wherein R 3 and R 4 are each hydrogen, alkyl, aryl or aralkyl; R 5 is up to three hydrogen atoms, alkyl, aryl, alkaryl, aralkyl, halogen or nitro; and R 6 is up to four hydrogen atoms, fused phenyl, alkyl, aryl, alkaryl, aralkyl, halogen or nitro; X is --F,--Cl,--Br,--I,--CN,--SR 7 ,--SAr,--N 3 ,--OAr, ##STR14## an alkyl, aryl, alkaryl or aralkyl group containing up to nine carbon atoms.
Claim 2
Dependent Claim
73 words
A compound of the formula ##STR13## wherein R 3 and R 4 are each hydrogen, alkyl, aryl or aralkyl; R 5 is up to three hydrogen atoms, alkyl, aryl, alkaryl, aralkyl, halogen or nitro; and R 6 is up to four hydrogen atoms, fused phenyl, alkyl, aryl, alkaryl, aralkyl, halogen or nitro; X is --F,--Cl,--Br,--I,--CN,--SR 7 ,--SAr,--N 3 ,--OAr, ##STR14## an alkyl, aryl, alkaryl or aralkyl group containing up to nine carbon atoms.
Claim 3
Dependent Claim
24 words
A compound of claim 1 wherein R 3 , R 4 and R 6 are hydrogen, R 5 is 2-halogen and X is chlorine.
Claim 4
Dependent Claim
10 words
A compound of claim 2 wherein R 5 is 2-chloro.
Claim 5
Dependent Claim
24 words
A compound of claim 1 wherein R 3 , R 4 and R 6 are hydrogen R 5 is 2-phenyl and X is chlorine.
Claim 6
Dependent Claim
1 words
2-Chloro-1-indenylmethylchloroformate.
Claim 7
Dependent Claim
1 words
2-Chloro-1-indenylmethylchloroformate.
Claim 8
Dependent Claim
1 words
1-Indenylmethylchloroformate.
Claim 9
Dependent Claim
1 words
1-Indenylmethylchloroformate.
Claim 10
Dependent Claim
1 words
2-Phenyl-1-indenylmethychloroformate.
Claim 11
Dependent Claim
1 words
2-Phenyl-1-indenylmethychloroformate.
Claim 12
Dependent Claim
1 words
1-Benz(f)indenylmethylchloroformate.
Claim 13
Dependent Claim
1 words
1-Benz(f)indenylmethylchloroformate.
Claim 14
Dependent Claim
1 words
2-benzyl-1-indenylmethylchloroformate.
Claim 15
Dependent Claim
1 words
2-benzyl-1-indenylmethylchloroformate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-04-01 | 1988-10-01 | 1989-04-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-04-01 | 1992-10-01 | 1993-04-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-04-01 | 1996-10-01 | 1997-04-02 | $7700.00 | Window Closed / Lapsed |