US4492684A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Slow release injectable insulin composition
Assignee: Sanofi Pasteur Ltd
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Filing: 1983-06-20
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Granted: 1985-01-08
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Expires: 2003-06-20
Abstract
Abstract A slow release injectable insulin composition is provided which is able to control blood sugar levels over extended periods of time. The albumin is partially cross-linked using a concentration of glutaraldehyde which is less than 3.75% v/w of the albumin to form a matrix enclosing the insulin. The composition conveniently is provided in the form of microbeads.
Inventors
- 👤 Mattheus F. A. Goosen
- 👤 Anthony M. F. Sun
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:56
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2063; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/28; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1658
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
77 words
A biodegradable insulin-containing composition suitable for administration to a living body for the control of blood sugar levels therein, comprising a matrix of partially cross-linked physically-native albumin and insulin where the extent of said partial cross-linking is such as to permit insulin to be released from the matrix by diffusion and/or erosion when positioned in the body, said cross-linking being achieved by the use of glutaraldehyde in a concentration of less than 3.75% v/w of the albumin.
Claim 2
Dependent Claim
77 words
A biodegradable insulin-containing composition suitable for administration to a living body for the control of blood sugar levels therein, comprising a matrix of partially cross-linked physically-native albumin and insulin where the extent of said partial cross-linking is such as to permit insulin to be released from the matrix by diffusion and/or erosion when positioned in the body, said cross-linking being achieved by the use of glutaraldehyde in a concentration of less than 3.75% v/w of the albumin.
Claim 3
Dependent Claim
20 words
The composition of claim 1 wherein the concentration of glutaraldehyde is about 1.25 to about 3.12% v/w of the albumin.
Claim 4
Dependent Claim
11 words
The composition of claim 1 in the form of injectable microbeads.
Claim 5
Dependent Claim
18 words
The composition of claim 1 wherein said insulin comprises about 5 to about 40% w/w of the composition.
Claim 6
Independent Claim
107 words
A method of formation of an insulin-containing biodegradable composition useful for administration to a living body for the control of blood sugar levels therein, which comprises: forming an aqueous suspension of native albumin, insulin crystals and glutaraldehyde in a concentration of less than 3.75% v/w of the albumin, adding said aqueous suspension to an oil phase under shear to form a water-in-oil emulsion and to cross-link the albumin with said glutaraldehyde to form microbeads of a matrix of partially cross-linked albumin and insulin which permit insulin to be released therefrom by diffusion and/or erosion when positioned in the body, and recovering the microbeads from the oil phase.
Claim 7
Independent Claim
107 words
A method of formation of an insulin-containing biodegradable composition useful for administration to a living body for the control of blood sugar levels therein, which comprises: forming an aqueous suspension of native albumin, insulin crystals and glutaraldehyde in a concentration of less than 3.75% v/w of the albumin, adding said aqueous suspension to an oil phase under shear to form a water-in-oil emulsion and to cross-link the albumin with said glutaraldehyde to form microbeads of a matrix of partially cross-linked albumin and insulin which permit insulin to be released therefrom by diffusion and/or erosion when positioned in the body, and recovering the microbeads from the oil phase.
Claim 8
Dependent Claim
14 words
The method of claim 5 effected at a temperature less than about 20° C.
Claim 9
Dependent Claim
18 words
The method of claim 5 wherein the aqueous suspension has a pH of about 5.5 to about 8.5.
Claim 10
Dependent Claim
21 words
The method of claim 5 wherein the amount of insulin used provides about 5 to about 40% w/w of the composition.
Claim 11
Independent Claim
98 words
A method of administrating insulin to a human body for the control of blood sugar levels therein, which comprises injecting into the human body an effective quantity of biodegradable microbeads comprising a matrix of partially cross-linked physically-native albumin and insulin wherein the extent of said partial cross-linking is such as to permit insulin to be released by diffusion and/or erosion over an extended period to the body into which the microbeads are injected to achieve said blood sugar control, said cross-linking being achieved by the use of glutaraldehyde in a concentration less than 3.75 v/w of the albumin.
Claim 12
Independent Claim
98 words
A method of administrating insulin to a human body for the control of blood sugar levels therein, which comprises injecting into the human body an effective quantity of biodegradable microbeads comprising a matrix of partially cross-linked physically-native albumin and insulin wherein the extent of said partial cross-linking is such as to permit insulin to be released by diffusion and/or erosion over an extended period to the body into which the microbeads are injected to achieve said blood sugar control, said cross-linking being achieved by the use of glutaraldehyde in a concentration less than 3.75 v/w of the albumin.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-01-08 | 1988-07-09 | 1989-01-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-01-08 | 1992-07-09 | 1993-01-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-01-08 | 1996-07-09 | 1997-01-08 | $7700.00 | Window Closed / Lapsed |