US4485088A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of treatment of fibrotic lesions by topical administration of lathyrogenic drugs
Assignee: LATHROTEC Inc A CORP OF ARIZONA
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Filing: 1982-03-26
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Granted: 1984-11-27
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Expires: 2002-03-26
Abstract
Abstract The disclosure deals with a method of treating fibrotic lesions related to abnormal collagen polymerization by topical administration of lathyrogenic substances, such as β-aminopropionitrile fumarate, aminoacetonitrile, D-penicillamine, into the site of the injury. The lathyrogenic drugs are administered by local injection or onto the skin and percutaneously transported into the site of the lesion. Lathyrogens, administered locally as a single drug or in combination do not produce any local or systemic toxic effects and are improving the function of the pathological fibrosis based on the accumulation of polymerized collagenous protein.
Inventors
- 👤 Milos Chvapil
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 03:54
CPC Classifications
A; A61; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/44; A61K; A61K31/00; A61K31/275; A61L2300/00; A61L2300/20; A61L2300/204
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
43 words
A method of treating a wound to reduce the extent of collagen crosslinking at the wound site, comprising preparing a drug preparation containing beta-aminopropionitrile in a drug carrier, and applying a therapeutically effective amount of the drug preparation locally to the wound site.
Claim 2
Independent Claim
43 words
A method of treating a wound to reduce the extent of collagen crosslinking at the wound site, comprising preparing a drug preparation containing beta-aminopropionitrile in a drug carrier, and applying a therapeutically effective amount of the drug preparation locally to the wound site.
Claim 3
Dependent Claim
39 words
The method of claim 1, wherein the drug preparation is prepared to include beta-aminopropionitrile at a concentration between about 0.2M and 2M, and said applying includes placing the preparation in contact with the skin surface of the wound site.
Claim 4
Dependent Claim
44 words
The method of claim 2, wherein the drug carrier includes water or water and DMSO, and said applying includes placing the drug preparation on the skin at the wound site, and covering the site with an occlusive material to reduce drying at the site.
Claim 5
Dependent Claim
27 words
The method of claim 3, wherein the drug preparation is contained in a porous hydrophilic support which is placed against the skin surface of the wound site.
Claim 6
Dependent Claim
18 words
The method of claim 2, wherein said applying includes infusing the wound site subcutaneously with the drug preparation.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-11-27 | 1988-05-28 | 1988-11-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-11-27 | 1992-05-28 | 1992-11-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-11-27 | 1996-05-28 | 1996-11-27 | $7700.00 | Window Closed / Lapsed |