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US4459278A Expired / Lapsed US ⏱️ 0.0 years remaining

Composition and method of immobilizing emetics and method of treating human beings with emetics

Assignee: Clear Lake Development Group
•
Filing: 1983-03-07
•
Granted: 1984-07-10
•
Expires: 2003-03-07
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Abstract

Abstract A therapeutic composition is coated with a mixture of an emetic chemical and an inert material. A method for reducing absorption into the body of a being of an emetic chemical while still retaining localized emetic activity comprises combining prior to ingestion of the chemical, the emetic chemical with a material that is substantially inert to a gastrointestinal environment such that when the combination is ingested and passed along the gastrointestinal tract, localized emetic activity is available while an undesirable amount of the emetic chemical is not absorbed into the body. A method of inducing emesis in the body of a being to preclude death from accidental or intentional overdosage of a therapeutic composition, which is normally of the type which if ingested by prescription is safe, but if excessively ingested is lethal while simultaneously reducing absorption of an emetic chemical into the body. The method comprising the steps of: combining an emetic chemical with a material that is substantially inert to a gastrointestinal environment; coating the surface of said therapeutic composition with the combination; controlling the quantity of said emetic chemical coated on the surface of the therapeutic composition such that no emesis ensues if normal prescription directions are followed or if no overdosage occurs; ingesting excessive quantities by the being of said therapeutic composition; and emesising by the being of the ingested excessive quantities of coated therapeutic composition in order to render the therapeutic compositions harmless and preclude death or serious illness to the being.

Inventors

  • 👤 Garry L. Porter

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 19:16
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2072; A61K9/2086; A61K9/209; A61K45/00; A61K45/06; A61K9/48; A61K9/4891

Claims Analysis

Total Claims: 8
Claim 1
Independent Claim 142 words
A therapeutic composition adapted to prevent drug overdosage and adapted for oral administration in addition to therapeutic ingredients having psychoactive characteristics comprising a coating of a-mixture of an emetic chemical and an inert cation-exchange resin material on the surface of said therapeutic composition irreversibly interacting with an emetine alkaloid to form an emetine resin complex mixture which exhibits emetic activity because the ionic interaction between the emetine and the cation-exchange resin are not involved in absorption and the resin-bound emetine fails to pass across a cell membrane; said emetic chemical and said inert material having a ratio of emetic chemical to inert material of from about 2:1 to about 1:50; and said coating including between about 0.25 to 2.0 mg. of the emetic chemical comprising a major proportion of methyl cephaeline and cephaeline, and a minor proportion of psychotrine, O-methylpsychotrine and emetamine.
Claim 2
Dependent Claim 142 words
A therapeutic composition adapted to prevent drug overdosage and adapted for oral administration in addition to therapeutic ingredients having psychoactive characteristics comprising a coating of a-mixture of an emetic chemical and an inert cation-exchange resin material on the surface of said therapeutic composition irreversibly interacting with an emetine alkaloid to form an emetine resin complex mixture which exhibits emetic activity because the ionic interaction between the emetine and the cation-exchange resin are not involved in absorption and the resin-bound emetine fails to pass across a cell membrane; said emetic chemical and said inert material having a ratio of emetic chemical to inert material of from about 2:1 to about 1:50; and said coating including between about 0.25 to 2.0 mg. of the emetic chemical comprising a major proportion of methyl cephaeline and cephaeline, and a minor proportion of psychotrine, O-methylpsychotrine and emetamine.
Claim 3
Dependent Claim 24 words
The therapeutic composition of claim 1 wherein the particle size of said cation-exchange resin varies from between about 100 mesh to about 500 mesh.
Claim 4
Dependent Claim 21 words
The therapeutic composition of claim 1 additionally including an opaque coating means surrounding said mixture of emetic chemical and inert material.
Claim 5
Dependent Claim 58 words
The therapeutic composition of claim 1 wherein said emetic chemical comprises between about 40% wt. and 85% wt. of methyl cephaeline, between about 10% wt. and 40% wt. of cephaeline, between about 2% wt. and 12% wt. of psychotrin, between about 1% wt. and 6% wt. of O-methylpsychotrine, and between about 1% wt. and 6% wt. of emetamine.
Claim 6
Dependent Claim 31 words
The therapeutic composition of claim 4 wherein said emetic chemical additionally includes between about 1% wt. and 6% wt. of ipecamine and between about 1% wt. and 6% wt. of hydro-ipecamine.
Claim 7
Dependent Claim 22 words
The therapeutic composition of claim 5 wherein said emetic chemical additionally includes between about 1% wt. and 6% wt. of ipecacuanhic acid.
Claim 8
Dependent Claim 22 words
The therapeutic composition of claim 6 wherein said emetic chemical additionally includes between about 1% wt. and 6% wt. of emetine hydrochloride.

References Cited (Backward Citations)

US1542006A Cited
US1589081A Cited
US2787579A Cited
US2990332A Cited
US3143465A Cited
US3091574A Cited
US3499960A Cited
GB1218102A Cited
US3934007A Cited
US4122169A Cited
US4140652A Cited
US4175119A Cited
US4221778A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1987-07-10 1988-01-09 1988-07-10 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1991-07-10 1992-01-09 1992-07-10 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1995-07-10 1996-01-09 1996-07-10 $7700.00 Window Closed / Lapsed

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