US4456591A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Therapeutic method for activating factor VII
Assignee: Baxter International Inc
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Filing: 1982-11-29
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Granted: 1984-06-26
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Expires: 2002-11-29
Abstract
Abstract Patients having a clotting factor defect can be successfully treated by the administration of a composition containing effective hemostatic amounts of factor VIIa. Preferably, the factor VIIa is substantially free of factors IXa and Xa. Procedures for preparing the above therapeutic compositions are also described. A method involving the activation of factor VII is set forth.
Inventors
- 👤 William R. Thomas
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:12
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/43; A61K38/46; A61K38/48; A61K38/482; A61K38/4846
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
108 words
A method for making a therapeutic composition, comprising (a) providing a starting material comprising factors VII and IX; (b) substantially separating factor VII from factor IX; (c) activating the factor VII-enriched fraction from step (b) by (i) selecting a condition which can be varied to control the degree of factor VII activation; (ii) prior to the completion of activation, determining the magnitude of the condition needed to activate the factor VII to a predetermined degree of activation; (iii) setting the condition to said magnitude; (iv) conducting the activation of the factor VII in accordance with the condition; and (v) terminating the activation at the predetermined degree of activation.
Claim 2
Independent Claim
108 words
A method for making a therapeutic composition, comprising (a) providing a starting material comprising factors VII and IX; (b) substantially separating factor VII from factor IX; (c) activating the factor VII-enriched fraction from step (b) by (i) selecting a condition which can be varied to control the degree of factor VII activation; (ii) prior to the completion of activation, determining the magnitude of the condition needed to activate the factor VII to a predetermined degree of activation; (iii) setting the condition to said magnitude; (iv) conducting the activation of the factor VII in accordance with the condition; and (v) terminating the activation at the predetermined degree of activation.
Claim 3
Dependent Claim
14 words
The method of claim 1 wherein the factor VII is activated by factor XIIa.
Claim 4
Dependent Claim
20 words
The method of claim 1 wherein the selected condition is the time of exposure of factor VII to factor XIIa.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-06-26 | 1987-12-26 | 1988-06-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-06-26 | 1991-12-26 | 1992-06-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-06-26 | 1995-12-26 | 1996-06-26 | $7700.00 | Window Closed / Lapsed |