US4455299A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Storage of blood platelets
Assignee: Baxter International Inc
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Filing: 1981-11-20
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Granted: 1984-06-19
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Expires: 2001-11-20
Abstract
Abstract Blood platelet pH is maintained between 6.0 and 7.6 for up to at least five days in relatively low gas permeability containers, e.g., standard polyvinyl chloride containers, by exposing the container to an atmosphere having an oxygen content greater than about 21%.
Inventors
- 👤 Gerald A. Grode
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:25
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/19; A01; A01N; A01N1/00; A01N1/10; A01N1/14; A01N1/146
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
44 words
A method comprising contacting a container holding about from 5×10 8 to 25×10 8 platelets/ml with an atmosphere having an oxygen proportion greater than about 21%, said container having a low oxygen transfer rate of about from 0.050 to 0.010 n moles/cm 2 -min-cmHg.
Claim 2
Independent Claim
44 words
A method comprising contacting a container holding about from 5×10 8 to 25×10 8 platelets/ml with an atmosphere having an oxygen proportion greater than about 21%, said container having a low oxygen transfer rate of about from 0.050 to 0.010 n moles/cm 2 -min-cmHg.
Claim 3
Dependent Claim
14 words
The method of claim 1 wherein the oxygen proportion is greater than about 60%.
Claim 4
Dependent Claim
12 words
The method of claim 2 wherein the atmosphere is substantially 100% oxygen.
Claim 5
Dependent Claim
53 words
In a method for storing a composition containing about from 5×10 8 to 25×10 8 platelets/ml in a gas-permeable container having a low oxygen transfer rate of about from 0.050 to 0.010 n moles/cm 2 -min-cmHg, the improvement comprising storing the container under an atmosphere having an oxygen proportion greater than about 21%.
Claim 6
Dependent Claim
53 words
In a method for storing a composition containing about from 5×10 8 to 25×10 8 platelets/ml in a gas-permeable container having a low oxygen transfer rate of about from 0.050 to 0.010 n moles/cm 2 -min-cmHg, the improvement comprising storing the container under an atmosphere having an oxygen proportion greater than about 21%.
Claim 7
Dependent Claim
51 words
In a method for storing a composition containing about from 5×10 8 to 25×10 8 platelets/ml in a container having an oxygen transfer rate of less than about 0.50 n moles/cm 2 -min-cmHg, the improvement comprising exposing the container to an atmosphere having a proportion of oxygen greater than about 21%.
Claim 8
Dependent Claim
51 words
In a method for storing a composition containing about from 5×10 8 to 25×10 8 platelets/ml in a container having an oxygen transfer rate of less than about 0.50 n moles/cm 2 -min-cmHg, the improvement comprising exposing the container to an atmosphere having a proportion of oxygen greater than about 21%.
Claim 9
Independent Claim
15 words
The method of claims 1 or 5 wherein the container is a polyvinyl chloride pouch.
Claim 10
Dependent Claim
20 words
The method of claim 6 wherein the polyvinyl chloride has a thickness greater than or equal to about 0.038 cm.
Claim 11
Dependent Claim
15 words
The method of claim 5 wherein the container is stored for up to 5 days.
Claim 12
Dependent Claim
61 words
In a method for storing a composition containing about from 5×10 8 to 25×10 8 platelets/ml in a plastic container formed from a film having an oxygen transfer rate of less than about 0.040 n moles/cm 2 -min-cmHg, the improvement comprising continuously exposing the container to an atmosphere comprising at least about 60% oxygen, and agitating the container during such exposure.
Claim 13
Dependent Claim
61 words
In a method for storing a composition containing about from 5×10 8 to 25×10 8 platelets/ml in a plastic container formed from a film having an oxygen transfer rate of less than about 0.040 n moles/cm 2 -min-cmHg, the improvement comprising continuously exposing the container to an atmosphere comprising at least about 60% oxygen, and agitating the container during such exposure.
Claim 14
Dependent Claim
16 words
The method of claim 9 wherein the proportion of carbon dioxide does not exceed about 5%.
Claim 15
Dependent Claim
73 words
A combination comprising: (a) a gas-permeable container having a low oxygen transfer rate of about from 0.050 to 0.010 n moles/cm 2 -min-cmHg, the container holding a composition containing about from 5×10 8 to 25×10 8 platelets/ml; (b) a plenum surrounding at least a portion of the container; (c) a source of gas having a proportion of oxygen greater than about 21% communicating with the plenum; and (d) means for agitating the container.
Claim 16
Dependent Claim
73 words
A combination comprising: (a) a gas-permeable container having a low oxygen transfer rate of about from 0.050 to 0.010 n moles/cm 2 -min-cmHg, the container holding a composition containing about from 5×10 8 to 25×10 8 platelets/ml; (b) a plenum surrounding at least a portion of the container; (c) a source of gas having a proportion of oxygen greater than about 21% communicating with the plenum; and (d) means for agitating the container.
Claim 17
Dependent Claim
73 words
A combination comprising: (a) a gas-permeable container having a low oxygen transfer rate of about from 0.050 to 0.010 n moles/cm 2 -min-cmHg, the container holding a composition containing about from 5×10 8 to 25×10 8 platelets/ml; (b) a substantially gas impermeable plenum enclosing at least a portion of the container; and (c) an atmosphere within the plenum in contact with the container which has a proportion of oxygen greater than about 21%.
Claim 18
Dependent Claim
73 words
A combination comprising: (a) a gas-permeable container having a low oxygen transfer rate of about from 0.050 to 0.010 n moles/cm 2 -min-cmHg, the container holding a composition containing about from 5×10 8 to 25×10 8 platelets/ml; (b) a substantially gas impermeable plenum enclosing at least a portion of the container; and (c) an atmosphere within the plenum in contact with the container which has a proportion of oxygen greater than about 21%.
Claim 19
Dependent Claim
13 words
The combination of claim 12 wherein the atmosphere is exchanged every 24 hours.
References Cited (Backward Citations)
US3276589A
Cited
US3441479A
Cited
US3735005A
Cited
US3729947A
Cited
US4132594A
Cited
US4082509A
Cited
US4228032A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-06-19 | 1987-12-19 | 1988-06-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-06-19 | 1991-12-19 | 1992-06-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-06-19 | 1995-12-19 | 1996-06-19 | $7700.00 | Window Closed / Lapsed |