US4451471A
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US
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Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same
Assignee: Novartis Corp
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Filing: 1982-03-08
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Granted: 1984-05-29
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Expires: 2002-03-08
Abstract
Abstract 2,4,5-Trisubstituted thiazoles of the formula ##STR1## in which each of R 1 and R 2 , independently of the other, represents an aryl or optionally N-oxidized heteroaryl radical each of which is unsubstituted or substituted by aliphatic hydrocarbon radicals, free, etherified or esterified hydroxy, etherified optionally S-oxidized mercapto, aliphatically substituted amino and/or trifluoromethyl, X represents thio, n represents 0, 1, or 2, and R 3 represents an aliphatic hydrocarbon radical that is unsubstituted or substituted by etherified or esterified hydroxy, etherified optionally S-oxidized mercapto and/or, in a position higher than the α-position, by oxo and/or hydroxy and optionally contains, in addition to terminally bonded hydroxy, sulpho that is present in salt form, or represents an araliphatic hydrocarbon radical that is unsubstituted or substituted in the aryl moiety as indicated for R 1 and R 2 , or represents a cycloaliphatic or cycloaliphatic-aliphatic hydrocarbon radical that is unsubstituted or substituted in a position higher than the α-position by free, etherified or esterified hydroxy, or represents a group of the formula ##STR2## in which m represents, 0, 1 or 2, R 4 represents an aliphatic hydrocarbon radical that is unsubstituted or substituted by etherified or esterified hydroxy, optionally S-oxidized etherified mercapto or, in a position higher than the α-position and lower than the ω-position, by oxo and/or hydroxy and that is optionally interrupted by oxa or thia, which may also be S-oxidized, or, if n and m represent O, represents a direct bond, and R 1 ' and R 2 ' have one of the meanings given for R 1 and R 2 , and pharmaceutically acceptable salts thereof are suitable for combating rheumatic disorders, preferably as active ingredients in anti-rheumatic medicaments. The invention relates to medicaments of this type and to non-chemical processes for their manufacture, and also to novel compounds of the formula I and to processes for their manufacture.
Inventors
- 👤 Pier G. Ferrini
- 👤 Richard Goschke
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:02
CPC Classifications
C; C07; C07D; C07D277/00; C07D277/02; C07D277/20; C07D277/32; A; A61; A61P; A61P29/00; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/44; C07D213/46; C07D213/50; C07D277/22; C07D277/24; C07D277/30; C07D277/36; C07D513/00; C07D513/02; C07D513/04
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
154 words
A novel 2,4,5-trisubstituted thiazole of the formula ##STR23## in which at least one of the radicals R 1 and R 2 represents optionally N-oxidised pyridyl and the other represents phenyl which is unsubstituted or substituted by lower alkyl, lower alkoxy, hydroxy, halogen or lower alkanoyloxy, lower alkylthio, lower alkanesulphinyl, lower alkanesulphonyl, amino, mono- or di-lower alkylamino, nitro and/or by trifluoromethyl, X represents thio, n represents 0, 1 or 2, R 3 represents lower alkyl, lower alkenyl or lower alkynyl, mono- or di-lower alkoxy-lower alkyl, lower alkylenedioxy-lower alkyl, lower alkanoyloxy-lower alkyl carrying the lower alkanoyloxy group in a position higher than the α-position, polyhalo-lower alkyl, hydroxy-lower alkyl wherein the hydroxy group is at a position higher than the α-position, oxo-lower alkyl carrying the oxo group in a position higher than the α-position, or phenyl-lower alkyl that is unsubstituted or substituted as indicated for R 1 and R 2 , or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
154 words
A novel 2,4,5-trisubstituted thiazole of the formula ##STR23## in which at least one of the radicals R 1 and R 2 represents optionally N-oxidised pyridyl and the other represents phenyl which is unsubstituted or substituted by lower alkyl, lower alkoxy, hydroxy, halogen or lower alkanoyloxy, lower alkylthio, lower alkanesulphinyl, lower alkanesulphonyl, amino, mono- or di-lower alkylamino, nitro and/or by trifluoromethyl, X represents thio, n represents 0, 1 or 2, R 3 represents lower alkyl, lower alkenyl or lower alkynyl, mono- or di-lower alkoxy-lower alkyl, lower alkylenedioxy-lower alkyl, lower alkanoyloxy-lower alkyl carrying the lower alkanoyloxy group in a position higher than the α-position, polyhalo-lower alkyl, hydroxy-lower alkyl wherein the hydroxy group is at a position higher than the α-position, oxo-lower alkyl carrying the oxo group in a position higher than the α-position, or phenyl-lower alkyl that is unsubstituted or substituted as indicated for R 1 and R 2 , or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
134 words
A compound according to claim 1 of the formula I in which at least one of R 1 and R 2 represents unsubstituted optionally N-oxidised pyridyl and the other denotes phenyl that is unsubstituted or substituted by lower alkoxy, hydroxy, halogen, lower alkanoyloxy, lower alkylthio, lower alkanesulphinyl, di-lower alkylamino and/or trifluoromethyl, X represents thio, n represents 0, 1 or 2, R 3 represents lower alkyl, or lower alkenyl or lower alkynyl each of which is bonded via a saturated carbon atom, lower alkoxy-lower alkyl, lower alkanoyloxy-lower alkyl carrying the lower alkanoyloxy group in a position higher than the α-position, lower hydroxy-lower alkyl which carries the hydroxy group in a position higher than the α-position, or oxo-lower alkyl carrying the oxo group in a position higher than the α-position, or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
184 words
A compound according to claim 1 of the formula I in which at least one of the radicals R 1 and R 2 represents optionally N-oxidised pyridyl, and the other represents phenyl that is unsubstituted or substituted by lower alkoxy having up to and including 4 carbon atoms, lower alkylthio having up to and including 4 carbon atoms, halogen having an atomic number of up to and including 35, hydroxy and/or trifluoromethyl, X represents thio, n represents 0, 1 or 2, and R 3 represents lower alkyl having up to and including 4 carbon atoms, or any one of the following, each of which carries the oxo, hydroxy, lower alkanoyloxy, lower alkoxy or lower alkylenedioxy group(s) in a position higher than the α-position: oxo- or hydroxy-lower alkyl each having up to and including 4 carbon atoms, lower alkanoyloxy-lower alkyl, each moiety having up to and including 4 carbon atoms, mono- or di-lower alkoxy-lower alkyl, each moiety having up to and including 4 carbon atoms, or lower alkylenedioxy-lower alkyl, each moiety having up to and including 4 carbon atoms, or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
110 words
A compound according to claim 1 of the formula I in which at least one of the radicals R 1 and R 2 represents pyridyl and the other represents phenyl that is unsubstituted or substituted by lower alkoxy having up to and including 4 carbon atoms or halogen having an atomic number of up to and including 35, X represents thio, n represents 0, 1 or 2, and R 3 represents lower alkyl having up to and including 4 carbon atoms, ω-hydroxy-lower alkyl having from 2 to 4 carbon atoms, or 2- or 3-lower alkoxy-lower alkyl having up to and including 4 carbon atoms, or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
15 words
A compound according to claim 1 that is 2-methylthio-5-phenyl-4-(3-pyridyl)-thiazole or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
15 words
A compound according to claim 1 that is 2-ethylthio-5-phenyl-4-(3-pyridyl)-thiazole or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
16 words
A compound according to claim 1 that is 2-(2-hydroxyethylthio)-5-phenyl-4-(3 -pyridyl)-thiazole or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
15 words
A compound according to claim 1 that is 2-methanesulphinyl-5-phenyl-4-(3-pyridyl)-thiazole or a pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
15 words
A compound according to claim 1 that is 2-methanesulphonyl-5-phenyl-4-(3-pyridyl)-thiazole or a pharmaceutically acceptable salt thereof.
Claim 11
Dependent Claim
15 words
A compound according to claim 1 that is 2-ethanesulphinyl-5-phenyl-4-(3-pyridyl)-thiazole or a pharmaceutically acceptable salt thereof.
Claim 12
Dependent Claim
15 words
A compound according to claim 1 that is 2-ethanesulphonyl-5-phenyl-4-(3-pyridyl)-thiazole or a pharmaceutically acceptable salt thereof.
Claim 13
Dependent Claim
15 words
A compound according to claim 1 that is 2-(2-hydroxyethanesulphinyl)-5-phenyl-4-(3-pyridyl)-thiazole or a pharmaceutically acceptable salt thereof.
Claim 14
Dependent Claim
15 words
A compound according to claim 1 that is 2-(2-hydroxyethanesulphonyl)-5-phenyl-4-(3-pyridyl)-thiazole or a pharmaceutically acceptable salt thereof.
Claim 15
Dependent Claim
15 words
A compound according to claim 1 that is 2-(1,1,2,2-tetrafluoroethylthio)-5-phenyl-4-(3-pyridyl)-thiazole or a pharmaceutically acceptable salt thereof.
Claim 16
Dependent Claim
15 words
A compound according to claim 1 that is 2-methylthio-4-phenyl-5-(3-pyridyl)-thiazole or a pharmaceutically acceptable salt thereof.
Claim 17
Dependent Claim
15 words
A compound according to claim 1 that is 2-ethylthio-4-phenyl-5-(3-pyridyl)-thiazole or a pharmaceutically acceptable salt thereof.
Claim 18
Dependent Claim
15 words
A compound according to claim 1 that is 2-(2-hydroxyethylthio)-4-phenyl-5-(3-pyridyl)-thiazole or a pharmaceutically acceptable salt thereof.
Claim 19
Dependent Claim
15 words
A compound according to claim 1 that is 2-methanesulphinyl-4-phenyl-5-(3-pyridyl)-thiazole or a pharmaceutically acceptable salt thereof.
Claim 20
Dependent Claim
15 words
A compound according to claim 1 that is 2-methanesulphonyl-4-phenyl-5-(3-pyridyl)-thiazole or a pharmaceutically acceptable salt thereof.
Claim 21
Dependent Claim
13 words
A compound according to claim 1 that is 2-ethanesulphonyl-4-phenyl-5-(3-pyridyl)-thiazole or a salt thereof.
Claim 22
Dependent Claim
15 words
A compound according to claim 1 that is 2-ethanesulphinyl-4-phenyl-5-(3-pyridyl)-thiazole or a pharmaceutically acceptable salt thereof.
Claim 23
Dependent Claim
15 words
A compound according to claim 1 that is 2-(2-hydroxyethanesulphinyl)-4-phenyl-5-(3-pyridyl)-thiazole or a pharmaceutically acceptable salt thereof.
Claim 24
Dependent Claim
15 words
A compound according to claim 1 that is 2-(2-hydroxyethanesulphonyl)-4-phenyl-5-(3-pyridyl)-thiazole or a pharmaceutically acceptable salt thereof.
Claim 25
Dependent Claim
15 words
A compound according to claim 1 that is 2-(2-hydroxyethylthio)-4-phenyl-5-(3-pyridyl)-thiazole or a pharmaceutically acceptable salt thereof.
Claim 26
Dependent Claim
23 words
An antiinflammatory pharmaceutical composition comprising an effective amount of a compound according to claim 1 in the presence of a pharmaceutically acceptable carrier.
Claim 27
Dependent Claim
26 words
A method for treating inflammation comprising administering to warm blooded animals in need of such administration an effective amount of a compound according to claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-05-29 | 1987-11-28 | 1988-05-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-05-29 | 1991-11-28 | 1992-05-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-05-29 | 1995-11-28 | 1996-05-29 | $7700.00 | Window Closed / Lapsed |