US4431428A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bio-artificial organ using microencapsulated enzymes
Assignee: BIOMEDICS Inc AN IL CORP
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Filing: 1981-09-30
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Granted: 1984-02-14
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Expires: 2001-09-30
Abstract
Abstract A bio-artificial organ containing a biochemically active matrix is disclosed. The biochemically active matrix includes biochemically active enzyme-containing microcapsules entrapped within a gel matrix. An extracorporeal blood flow can be passed through the organ and over the biochemically active matrix to permit the enzyme to perform its enzymatic function on a substrate in the blood.
Inventors
- 👤 Gottfried Schmer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:43
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3687; A61M1/3689; C; C12; C12N; C12N11/00; C12N11/02; C12N11/04
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
55 words
A biochemically active matrix suitable for use in bio-artificial organ comprising at least one biochemically active enzyme disposed within a plurality of semi-permeable microcapsules which are entrapped within a gel matrix, the gel matrix and microcapsule each having a permeability such that the substrate and enzyme-substrate reaction products pass to and from the microencapsulated enzyme.
Claim 2
Dependent Claim
55 words
A biochemically active matrix suitable for use in bio-artificial organ comprising at least one biochemically active enzyme disposed within a plurality of semi-permeable microcapsules which are entrapped within a gel matrix, the gel matrix and microcapsule each having a permeability such that the substrate and enzyme-substrate reaction products pass to and from the microencapsulated enzyme.
Claim 3
Dependent Claim
14 words
The biochemically active matrix of claim 1 wherein the microcapsules are red cell ghosts.
Claim 4
Dependent Claim
17 words
The biochemically active matrix of claim 1 wherein the microcapsule wall is made of a synthetic material.
Claim 5
Dependent Claim
14 words
The biochemically active matrix of claim 1 wherein the biochemically active enzyme is urease.
Claim 6
Dependent Claim
16 words
The biochemically active matrix of claim 1 wherein the gel matrix is formed of a polysaccharide.
Claim 7
Dependent Claim
18 words
The biochemically active matrix of claim 5 wherein the gel matrix is formed of an irreversibly gelled agarose.
Claim 8
Dependent Claim
20 words
The biochemically active matrix of claim 6 wherein the agarose has a temperature of irreversible gelation of about 37° C.
Claim 9
Dependent Claim
47 words
A biochemically active matrix for use in a bio-artificial organ comprising: a biochemically active enzyme disposed within a plurality of red cell ghosts which are entrapped within an agarose gel having a permeability such that substrate and enzyme-substrate reaction product can pass and to from the enzyme.
Claim 10
Dependent Claim
47 words
A biochemically active matrix for use in a bio-artificial organ comprising: a biochemically active enzyme disposed within a plurality of red cell ghosts which are entrapped within an agarose gel having a permeability such that substrate and enzyme-substrate reaction product can pass and to from the enzyme.
Claim 11
Dependent Claim
80 words
A bio-artificial organ comprising, in operative combination: (a) a reactor housing defining an enclosed space, an inlet and an outlet, and the inner surface of the reactor being of material compatible with an extracorporeal blood flow; (b) a gel matrix within the reactor housing; (c) a plurality of semi-permeable microcapsules entrapped within the gel matrix; and (d) a biochemically active enzyme disposed within the microcapsules; the gel matrix and the microcapsules each being permeable to substrate and enzyme-substrate reaction products.
Claim 12
Dependent Claim
80 words
A bio-artificial organ comprising, in operative combination: (a) a reactor housing defining an enclosed space, an inlet and an outlet, and the inner surface of the reactor being of material compatible with an extracorporeal blood flow; (b) a gel matrix within the reactor housing; (c) a plurality of semi-permeable microcapsules entrapped within the gel matrix; and (d) a biochemically active enzyme disposed within the microcapsules; the gel matrix and the microcapsules each being permeable to substrate and enzyme-substrate reaction products.
Claim 13
Dependent Claim
25 words
A bio-artificial organ of claim 9 wherein the gel matrix is formed of an agarose which irreversibly gels at a temperature of about 37° C.
Claim 14
Dependent Claim
13 words
The bio-artificial organ of claim 9 wherein the microcapsules are red cell ghosts.
Claim 15
Dependent Claim
22 words
The bio-artificial organ of claim 9 wherein the gel matrix is disposed on a physical support means positioned within the reactor housing.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-02-13 | 1987-08-15 | 1988-02-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-02-13 | 1991-08-15 | 1992-02-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-02-13 | 1995-08-15 | 1996-02-14 | $7700.00 | Window Closed / Lapsed |