US4397843A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Mannose-6-phosphate-low density protein reagent effective against hypercholesterolemia
Assignee: United States Department of Health and Human Services
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Filing: 1982-01-21
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Granted: 1983-08-09
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Expires: 2002-01-21
Abstract
Abstract A new reagent effective in inhibiting cholesterol synthesis 75% in human fibroblasts derived from patients suffering from the disease familial hypercholestrolemia is Man6P-low density lipoprotein and is effective in tissue culture test systems at 100 μg/ml after a ten-hour exposure. The broad purpose of this invention is to modify the receptor specificity of a protein so that it will enter cells which were previously impermeable and exert new effects or reverse a pathological condition. That is, the compound of this invention is a useful reagent in the selective cytotoxic treatment of hypercholesterolemia.
Inventors
- 👤 David M. Neville, Jr.
- 👤 Richard J. Youle
- 👤 Gary J. Murray
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:51
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/415; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/61; A61K47/68; A61K47/6801; A61K47/6803; A61K47/6811; A61K47/6817; A61K47/6819; A61K47/6821; A61K47/6823; C07K14/435; C07K14/775; A61K38/00
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
14 words
A reagent for treating familial hypercholestrolemia comprising an effective amount of mannose-6-phosphate-low density lipoprotein.
Claim 2
Dependent Claim
14 words
A reagent for treating familial hypercholestrolemia comprising an effective amount of mannose-6-phosphate-low density lipoprotein.
Claim 3
Dependent Claim
14 words
A cholesterol synthesis inhibiting reagent composition comprising an effective amount of mannose-6-phosphate-low density protein.
Claim 4
Dependent Claim
14 words
A cholesterol synthesis inhibiting reagent composition comprising an effective amount of mannose-6-phosphate-low density protein.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-08-08 | 1987-02-07 | 1987-08-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-08-08 | 1991-02-07 | 1991-08-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-08-08 | 1995-02-07 | 1995-08-09 | $7700.00 | Window Closed / Lapsed |