US4377512A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Oxygen carrier for blood substitute
Assignee: Ajinomoto Co Inc
•
Filing: 1981-06-26
•
Granted: 1983-03-22
•
Expires: 2001-06-26
Abstract
Abstract A hemoglobin modified by covalently bound inulin.
Inventors
- 👤 Katsumi Ajisaka
- 👤 Yuji Iwashita
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:23
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/795; C07K14/805; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/60; A61K38/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
7 words
A hemoglobin modified by covalently bound inulin.
Claim 2
Dependent Claim
7 words
A hemoglobin modified by covalently bound inulin.
Claim 3
Dependent Claim
21 words
The compound of claim 1, wherein said hemoglobin is obtained from cattle, swine, sheep, horses, dogs, monkeys, chickens or human beings.
Claim 4
Dependent Claim
26 words
The compound of claim 1, wherein the hemoglobin component of said modified hemoglobin is a sugar nucleotide, alcohol, carboxylic acid, sulphate or phosphate derivative of hemoglobin.
Claim 5
Dependent Claim
22 words
The compound of claim 1, wherein the inulin component of said modified hemoglobin has a molecular weight of 4,000 to 6,000 daltons.
Claim 6
Dependent Claim
20 words
The compound of claim 1, wherein said compound comprises from 1 to 20 inulin units attached to one hemoglobin subunit.
Claim 7
Dependent Claim
21 words
The compound of claim 5, wherein the number of inulin units combined with one hemoglobin subunit ranges from 1 to 15.
Claim 8
Independent Claim
43 words
A method of preparing hemoglobin modified by covalently bound inulin, comprising: coupling inulin units via hydroxyl groups thereon to amino groups on a hemoglobin subunit by a coupling agent selected from the group consisting of cyanogen bromide, cyanuric chloride, 2,2-dichlorobenzidine, p,p'-difluoro-m,m'-dinitrodiphenylsulfone or 2,4-dichloronitrobenzene.
Claim 9
Independent Claim
43 words
A method of preparing hemoglobin modified by covalently bound inulin, comprising: coupling inulin units via hydroxyl groups thereon to amino groups on a hemoglobin subunit by a coupling agent selected from the group consisting of cyanogen bromide, cyanuric chloride, 2,2-dichlorobenzidine, p,p'-difluoro-m,m'-dinitrodiphenylsulfone or 2,4-dichloronitrobenzene.
Claim 10
Independent Claim
32 words
A method of preparing hemoglobin modified by covalently bound inulin, comprising: esterifying inulin with a dicarboxylic acid, and reacting the remaining free carboxyl group of the partially reacted dicarboxylic acid with hemoglobin.
Claim 11
Independent Claim
32 words
A method of preparing hemoglobin modified by covalently bound inulin, comprising: esterifying inulin with a dicarboxylic acid, and reacting the remaining free carboxyl group of the partially reacted dicarboxylic acid with hemoglobin.
Claim 12
Dependent Claim
21 words
The compound of claim 1, wherein the hemoglobin component of said modified hemoglobin is a pyridoxal-5'-phosphate or pyridoxal-5'-sulphate derivative of hemoglobin.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-03-21 | 1986-09-20 | 1987-03-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-03-21 | 1990-09-20 | 1991-03-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-03-21 | 1994-09-20 | 1995-03-22 | $7700.00 | Window Closed / Lapsed |