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US4376764A Expired / Lapsed US ⏱️ 0.0 years remaining

Silver ion gel compositions

Assignee: BASF Corp
•
Filing: 1981-08-10
•
Granted: 1983-03-15
•
Expires: 2001-08-10
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Abstract

Abstract Silver ion gel compositions containing a polyoxybutylene-polyoxyethylene block copolymer that maintain their gel characteristics at temperatures below 20 DEG C. These gel compositions may be used to treat burn wounds and superficial ulcers.

Inventors

  • 👤 Irving R. Schmolka

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 18:32
CPC Classifications
A; A61; A61L; A61L26/00; A61L26/0061; A61L26/0066; A61K; A61K31/00; A61K31/74; A61K31/765; A61K31/77; A61L26/0009; A61L26/0019; A61L2300/00; A61L2300/10; A61L2300/102; A61L2300/104; A61L2300/40; A61L2300/404; Y; Y10; Y10S; Y10S424/00; Y10S424/13

Claims Analysis

Total Claims: 9
Claim 1
Independent Claim 365 words
A silver ion gel composition which remains a gel at temperatures below room temperature comprising an amount of water-soluble or water-insoluble silver salt effective to treat a burn wound, about 85 to about 65 percent by weight water and about 15 to about 35 percent by weight of a polyoxybutylene-polyoxyethylene block copolymer, said block copolymer being a cogeneric mixture of conjugated polyoxybutylene-polyoxyethylene compounds containing in their structure oxybutylene groups, oxyethylene groups and an organic radical derived from a water-soluble organic compound containing a plurality of reactive hydrogen atoms and 2 to 12 carbon atoms; the compounds being characterized in that all of the oxybutylene groups are present in polyoxybutylene chains that are attached to the organic radical at the site of a reactive hydrogen atom thereby constituting a polyoxybutylene polymer; the oxyethylene groups being attached to the oxybutylene polymer in polyoxyethylene chains; the average molecular weight of the polyoxybutylene polymers in the mixture being at least 1200, as determined by hydroxyl number, and the oxyethylene groups present constituting 50 to 80 percent, by weight, of the mixture, with the provisos that (a) when the oxybutylene polymer molecular weight is about 1200, then the minimum polyoxyethylene content is about 60 percent by weight of the block copolymer and the minimum block copolymer content to form a gel is about 25 percent by weight of the aqueous gel composition; (b) when the oxybutylene polymer molecular weight is about 1800, then the minimum polyoxyethylene content is about 55 percent by weight of the block copolymer and the minimum block copolymer content to form a gel is about 20 percent by weight of the aqueous gel compositions; (c) when the oxybutylene polymer molecular weight is about 2400, then the minimum polyoxyethylene content is about 50 percent by weight of the block copolymer and the minimum block copolymer content to form a gel is about 16 percent by weight of the aqueous gel composition; (d) when the oxybutylene polymer molecular weight is about 3000, then the minimum polyoxyethylene content is about 45 percent by weight of the block copolymer and the minimum block copolymer content to form a gel is about 16 percent by weight of the aqueous gel composition.
Claim 2
Dependent Claim 365 words
A silver ion gel composition which remains a gel at temperatures below room temperature comprising an amount of water-soluble or water-insoluble silver salt effective to treat a burn wound, about 85 to about 65 percent by weight water and about 15 to about 35 percent by weight of a polyoxybutylene-polyoxyethylene block copolymer, said block copolymer being a cogeneric mixture of conjugated polyoxybutylene-polyoxyethylene compounds containing in their structure oxybutylene groups, oxyethylene groups and an organic radical derived from a water-soluble organic compound containing a plurality of reactive hydrogen atoms and 2 to 12 carbon atoms; the compounds being characterized in that all of the oxybutylene groups are present in polyoxybutylene chains that are attached to the organic radical at the site of a reactive hydrogen atom thereby constituting a polyoxybutylene polymer; the oxyethylene groups being attached to the oxybutylene polymer in polyoxyethylene chains; the average molecular weight of the polyoxybutylene polymers in the mixture being at least 1200, as determined by hydroxyl number, and the oxyethylene groups present constituting 50 to 80 percent, by weight, of the mixture, with the provisos that (a) when the oxybutylene polymer molecular weight is about 1200, then the minimum polyoxyethylene content is about 60 percent by weight of the block copolymer and the minimum block copolymer content to form a gel is about 25 percent by weight of the aqueous gel composition; (b) when the oxybutylene polymer molecular weight is about 1800, then the minimum polyoxyethylene content is about 55 percent by weight of the block copolymer and the minimum block copolymer content to form a gel is about 20 percent by weight of the aqueous gel compositions; (c) when the oxybutylene polymer molecular weight is about 2400, then the minimum polyoxyethylene content is about 50 percent by weight of the block copolymer and the minimum block copolymer content to form a gel is about 16 percent by weight of the aqueous gel composition; (d) when the oxybutylene polymer molecular weight is about 3000, then the minimum polyoxyethylene content is about 45 percent by weight of the block copolymer and the minimum block copolymer content to form a gel is about 16 percent by weight of the aqueous gel composition.
Claim 3
Dependent Claim 15 words
The silver ion gel composition of claim 1 wherein the silver salt is water soluble.
Claim 4
Dependent Claim 15 words
The silver ion gel composition of claim 1 wherein the silver salt is water insoluble.
Claim 5
Dependent Claim 13 words
The gel composition of claim 2 wherein the silver salt is silver nitrate.
Claim 6
Dependent Claim 13 words
The gel composition of claim 3 wherein the silver salt is silver sulfadiazine.
Claim 7
Dependent Claim 35 words
The gel composition of claim 1 wherein the block copolymer has an average molecular weight of the polyoxybutylene polymer of about 1800 and the oxyethylene groups constitute about 60 percent by weight of the mixture.
Claim 8
Dependent Claim 35 words
The gel composition of claim 4 wherein the block copolymer has an average molecular weight of the polyoxybutylene polymer of about 1800 and the oxyethylene groups constitute about 60 percent by weight of the mixture.
Claim 9
Dependent Claim 35 words
The gel composition of claim 5 wherein the block copolymer has an average molecular weight of the polyoxybutylene polymer of about 1800 and the oxyethylene groups constitute about 60 percent by weight of the mixture.

References Cited (Backward Citations)

GB722746A Cited
US2828345A Cited
US3057890A Cited
US3639575A Cited
US4326977A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1986-03-14 1986-09-13 1987-03-15 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1990-03-14 1990-09-13 1991-03-15 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1994-03-14 1994-09-13 1995-03-15 $7700.00 Window Closed / Lapsed

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