US4370349A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for preparing freeze-dried liposome compositions
Assignee: Syngenta Ltd
•
Filing: 1981-09-18
•
Granted: 1983-01-25
•
Expires: 2001-09-18
Abstract
Abstract Process for preparing a freeze-dried, potential liposome, mixture which comprises either (a) dissolving at least one liposome-forming amphipathic lipid, at least one biologically-active compound, and optionally one or more adjuvants, in a suitable solvent, and then freeze-drying the solution, or (b) preparing by any known method an aqueous liposome composition containing at least one biologically-active compound, and then freeze-drying the said aqueous liposome composition. Process for preparing an aqueous liposome composition which comprises dispersing said freeze-dried, potential liposome, mixture, obtained by procedure (a) or (b), in a suitable aqueous medium.
Inventors
- 👤 John R. Evans
- 👤 Francis J. T. Fildes
- 👤 Jean E. Oliver
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 03:27
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K9/1277
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
41 words
A method for the manufacture of a freeze-dried, potential liposome, mixture which comprises preparing an aqueous liposome composition comprising at least one lipid-soluble or lipid-bound biologically active compound, and then freeze-drying the said composition to produce a freeze-dried, potential liposome, mixture.
Claim 2
Independent Claim
41 words
A method for the manufacture of a freeze-dried, potential liposome, mixture which comprises preparing an aqueous liposome composition comprising at least one lipid-soluble or lipid-bound biologically active compound, and then freeze-drying the said composition to produce a freeze-dried, potential liposome, mixture.
Claim 3
Dependent Claim
18 words
The method claimed in claim 1 in which the liposomes contain at least one natural or synthetic lecithin.
Claim 4
Dependent Claim
15 words
The method claimed in claim 1 in which the biologically active compound is a medicament.
Claim 5
Dependent Claim
43 words
The method claimed in claim 1 in which there is present with the lipid and the biologically active compound at least one adjuvant selected from the group consisting of cholesterol, substances which provide a negative charge, and substances which provide a positive charge.
Claim 6
Dependent Claim
25 words
A new composition of matter which is the freeze-dried, potential liposome, mixture which is obtained as the product of the method claimed in claim 1.
Claim 7
Independent Claim
70 words
A method for the manufacture of an aqueous liposome preparation containing at least one lipid-soluble or lipid-bound biologically active compound, which comprises dispersing a freeze-dried, potential liposome, mixture in a suitable aqueous medium, the said freeze-dried, potential liposome, mixture being obtained by preparing an aqueous liposome composition comprising at least one lipid-soluble or lipid-bound biologically active compound, and then freeze-drying the said composition to produce a freeze-dried, potential liposome, mixture.
Claim 8
Independent Claim
70 words
A method for the manufacture of an aqueous liposome preparation containing at least one lipid-soluble or lipid-bound biologically active compound, which comprises dispersing a freeze-dried, potential liposome, mixture in a suitable aqueous medium, the said freeze-dried, potential liposome, mixture being obtained by preparing an aqueous liposome composition comprising at least one lipid-soluble or lipid-bound biologically active compound, and then freeze-drying the said composition to produce a freeze-dried, potential liposome, mixture.
Claim 9
Dependent Claim
24 words
An aqueous liposome preparation containing at least one lipid-soluble or lipid-bound biologically active compound, whenever obtained by a method as claimed in claim 6.
Claim 10
Dependent Claim
35 words
The method claimed in claim 6 in which there is present at least one adjuvant selected from the group consisting of cholesterol, substances which provide a negative charge, and substances which provide a positive charge.
Claim 11
Dependent Claim
23 words
An aqueous liposome preparation containing at least one lipid-soluble or lipid-bound biologically active compound, obtained by a method as claimed in claim 8.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-01-24 | 1986-07-26 | 1987-01-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-01-24 | 1990-07-26 | 1991-01-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-01-24 | 1994-07-26 | 1995-01-25 | $7700.00 | Window Closed / Lapsed |