US4347374A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Acid addition salts of N-trityl-α-fluoromethylhistidine enantiomer derivatives
Assignee: Merck and Co Inc
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Filing: 1980-07-21
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Granted: 1982-08-31
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Expires: 2000-07-21
Abstract
Abstract A process for resolving a mixture of α-fluoromethylhistidine enantiomers is described. The process features use of an ester derivative of α-fluoromethylhistidine. Novel diastereoisomer salts of said derivative are also disclosed.
Inventors
- 👤 Janos Kollonitsch
- 👤 Leroy M. Perkins
- 👤 George A. Doldouras
- 👤 Stephen Marburg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:26
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/64
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
8 words
(S) (-)-α-N im -trityl-α-fluoromethylhistidine methyl ester.d-α-bromocamphor-π-sulfonic acid salt.
Claim 2
Dependent Claim
8 words
(S) (-)-α-N im -trityl-α-fluoromethylhistidine methyl ester.d-α-bromocamphor-π-sulfonic acid salt.
Claim 3
Dependent Claim
9 words
(S) (-)-α-N im -trityl-α-fluoromethylhistidine methyl ester.2 d-α-bromocamphor-π-sulfonic acid salt.
Claim 4
Dependent Claim
9 words
(S) (-)-α-N im -trityl-α-fluoromethylhistidine methyl ester.2 d-α-bromocamphor-π-sulfonic acid salt.
Claim 5
Dependent Claim
10 words
S-(-) N im trityl-fluoromethylhistidine methyl ester.d-α-bromocamphor-π-sulfonic acid.H 2 O salt.
Claim 6
Dependent Claim
10 words
S-(-) N im trityl-fluoromethylhistidine methyl ester.d-α-bromocamphor-π-sulfonic acid.H 2 O salt.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-08-30 | 1986-03-01 | 1986-08-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-08-30 | 1990-03-01 | 1990-08-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-08-30 | 1994-03-01 | 1994-08-31 | $7700.00 | Window Closed / Lapsed |