US4340589A
Expired / Lapsed
US
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Antithrombin preparation and process for the production thereof
Assignee: Tanabe Pharma Corp
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Filing: 1979-06-18
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Granted: 1982-07-20
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Expires: 1999-06-18
Abstract
Abstract PCT No. PCT/JP79/00154 Sec. 371 Date Feb. 18, 1981 Sec. 102(e) Date Feb. 17, 1981 PCT Filed Jun. 18, 1979 PCT Pub. No. WO80/02798 PCT Pub. Date Dec. 24, 1980.An antithrombin preparation, secure and stable for a long period of time, can be obtained by freeze-drying an aqueous solution containing antithrombin-III as main component in the presence of an effective quantity of at least one member selected from the group consisting of proteins, sugars, amino acids, inorganic salts and salts of organic acids as stabilizer.
Inventors
- 👤 Yahiro Uemura
- 👤 Midori Nagatomo
- 👤 Satoshi Funakoshi
- 👤 Tadakazu Suyama
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 08:57
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/02; A61K35/00; A61K35/12; A61K35/14; A61K38/00; A61K38/005; A61K47/06; A61K47/08; A61K47/12; A61K47/16; A61K47/18; A61K47/183; A61K47/26; A61K47/30; A61K47/42; A61L; A61L2/00; A61L2/02; A61L2/04; A61P; A61P7/00; A61P7/02; C; C07; C07K; C07K14/00; C07K14/81; C07K14/8107; C07K14/811; C07K14/8121; C07K14/8128; A61L2103/00; A61L2103/05; A61L2103/09
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
36 words
A freeze-dried antithrombin preparation containing an effective quantity of antithrombin-III and an effective quantity of at least one member selected from the group consisting of albumin, urokinase, gelatin, mannitol, heparin, glycine and lysine as stabilizer therefore.
Claim 2
Dependent Claim
36 words
A freeze-dried antithrombin preparation containing an effective quantity of antithrombin-III and an effective quantity of at least one member selected from the group consisting of albumin, urokinase, gelatin, mannitol, heparin, glycine and lysine as stabilizer therefore.
Claim 3
Dependent Claim
27 words
A freeze-dried antithrombin preparation according to claim 1, wherein the quantity of said stabilizer is 0.1-5.0 parts by weight based on 1 part by weight of antithrombin-III.
Claim 4
Dependent Claim
21 words
A freeze-dried antithrombin preparation according to claim 1 wherein the antithrombin-III has been heat-treated for the purpose of inactivating hepatitis virus.
Claim 5
Dependent Claim
26 words
A freeze-dried antithrombin preparation according to claim 1, wherein there is employed at least one member selected from the group consisting of albumin, urokinase, and gelatin.
Claim 6
Dependent Claim
25 words
A freeze-dried antithrombin preparation according to claim 1, wherein there is employed at least one member selected from the group consisting of mannitol, and heparin.
Claim 7
Dependent Claim
25 words
A freeze-dried antithrombin preparation according to claim 1, wherein there is employed at least one member selected from the group consisting of glycine and lysine.
Claim 8
Dependent Claim
15 words
A freeze-dried antithrombin preparation according to claim 1 consisting essentially of antithrombin-III and said stabilizer.
Claim 9
Dependent Claim
11 words
A preparation according to claim 7 wherein the stabilizer is albumin.
Claim 10
Dependent Claim
11 words
A preparation according to claim 7 wherein the stabilizer is urokinase.
Claim 11
Dependent Claim
11 words
A preparation according to claim 7 wherein the stabilizer is gelatin.
Claim 12
Dependent Claim
11 words
A preparation according to claim 7 wherein the stabilizer is mannitol.
Claim 13
Dependent Claim
11 words
A preparation according to claim 7 wherein the stabilizer is heparin.
Claim 14
Dependent Claim
11 words
A preparation according to claim 7 wherein the stabilizer is glycine.
Claim 15
Dependent Claim
11 words
A preparation according to claim 7 wherein the stabilizer is lysine.
Claim 16
Dependent Claim
30 words
A process of remedying disseminated intravascular coagulation or fibrinopenia comprising administering to a patient suffering therefrom an effective amount of an aqueous solution of the antithrombin-III preparation of claim 1.
References Cited (Backward Citations)
US3842061A
Cited
US4087415A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-07-19 | 1986-01-18 | 1986-07-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-07-19 | 1990-01-18 | 1990-07-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-07-19 | 1994-01-18 | 1994-07-20 | $7700.00 | Window Closed / Lapsed |