US4337251A
Expired / Lapsed
US
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Method of avoiding and removing adhesions
Assignee: Ed Geistlich Soehne AG fuer Chemische Industrie
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Filing: 1980-05-06
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Granted: 1982-06-29
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Expires: 2000-05-06
Abstract
Abstract The invention provides a method of treatment of the human or animal body comprising the application of an aqueous solution containing a compound of formula I ##STR1## [wherein R 1 represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms and R 2 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms or a group of formula II ##STR2## in which R 1 is as defined above] to human or animal tissue subjected to surgical treatment whereby the incidence of adhesion formation is eliminated or substantially reduced or whereby existing adhesions are at least substantially detached or unblocked. There is also provided a solution for use in the above method.
Inventors
- 👤 Rolf W. Pfirrmann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:42
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/54; A61P; A61P43/00
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
94 words
A method of treatment of a human or animal in need of said treatment comprising the application of an aqueous solution containing a compound of formula I ##STR5## wherein R 1 represents a hydrogen atom and R 2 represents a hydrogen atom or a group of formula II ##STR6## in which R 1 is as defined above to human or animal tissue subjected to surgical treatment where no bacterial infection is present whereby the incidence of adhesion formation is eliminated or substantially reduced or whereby existing adhesions are at least substantially detached or unblocked.
Claim 2
Independent Claim
94 words
A method of treatment of a human or animal in need of said treatment comprising the application of an aqueous solution containing a compound of formula I ##STR5## wherein R 1 represents a hydrogen atom and R 2 represents a hydrogen atom or a group of formula II ##STR6## in which R 1 is as defined above to human or animal tissue subjected to surgical treatment where no bacterial infection is present whereby the incidence of adhesion formation is eliminated or substantially reduced or whereby existing adhesions are at least substantially detached or unblocked.
Claim 3
Dependent Claim
30 words
A method as claimed in claim 1 wherein the said application is effected for at least part of the time from shortly before to shortly after the said surgical treatment.
Claim 4
Dependent Claim
29 words
A method as claimed in claim 1 wherein the concentration of the said compound of formula I in the said aqueous solution is from 0.5 to 5% by weight.
Claim 5
Independent Claim
21 words
A method as claimed in any one of claims 1 to 3 wherein the said compound of formula I is bis-(1,1-dioxo-perhydro-1,2,4-thiadiazin-4-yl)-methane.
Claim 6
Dependent Claim
24 words
A method as claimed in claim 4 wherein the dosage of bis-(1,1-dioxo-perhydro-1,2,4-thiadiazin-4-yl)-methane is from 2 to 20 g per day for an adult human.
Claim 7
Dependent Claim
15 words
A method as claimed in claim 1 wherein the said aqueous solution further contains polyvinylpyrrolidone.
Claim 8
Dependent Claim
18 words
A method as claimed in claim 6 wherein the molecular weight of the polyvinylpyrrolidone is less than 30,000.
Claim 9
Dependent Claim
18 words
A method as claimed in claim 6 wherein the molecular weight of the polyvinylpyrrolidone is less than 10,000.
Claim 10
Dependent Claim
19 words
A method as claimed in claim 6 wherein the molecular weight of the polyvinylpyrrolidone is from 2,000 to 3,500.
Claim 11
Dependent Claim
18 words
A method as claimed in claim 1 wherein the said solution is applied by instillation or by infusion.
Claim 12
Dependent Claim
23 words
A method as claimed in claim 1 wherein the said surgical treatment involves surgery of the peritoneum, the heart or the fallopian tube.
Claim 13
Independent Claim
76 words
A method of treatment of a human or animal in need of said treatment comprising the application of an aqueous solution containing a compound of formula I ##STR7## wherein R 1 represents a hydrogen atom and R 2 represents a hydrogen atom or a group of formula II ##STR8## in which R 1 is as defined above to human or animal tissue subjected to surgical treatment whereby existing adhesions are at least substantially detached or unblocked.
Claim 14
Independent Claim
76 words
A method of treatment of a human or animal in need of said treatment comprising the application of an aqueous solution containing a compound of formula I ##STR7## wherein R 1 represents a hydrogen atom and R 2 represents a hydrogen atom or a group of formula II ##STR8## in which R 1 is as defined above to human or animal tissue subjected to surgical treatment whereby existing adhesions are at least substantially detached or unblocked.
Claim 15
Dependent Claim
30 words
A method as claimed in claim 12 wherein the said application is effected for at least part of the time from shortly before to shortly after the said surgical treatment.
Claim 16
Dependent Claim
29 words
A method as claimed in claim 12 wherein the concentration of the said compound of formula I in the said aqueous solution is from 0.5 to 5% by weight.
Claim 17
Independent Claim
21 words
A method as claimed in any one of claims 12 to 14 wherein the said compound of formula I is bis-(1,1-dioxo-perhydro-1,2,4-thiadiazin-4-yl)-methane.
Claim 18
Dependent Claim
18 words
A method as claimed in claim 12 wherein the said solution is applied by instillation or by infusion.
Claim 19
Dependent Claim
23 words
A method as claimed in claim 12 wherein the said surgical treatment involves surgery of the peritoneum, the heart or the fallopian tubes.
Claim 20
Dependent Claim
15 words
A method as claimed in claim 12 wherein the said aqueous solution further contains polyvinylpyrrolidone.
Claim 21
Dependent Claim
18 words
A method as claimed in claim 18 wherein the molecular weight of the polyvinylpyrrolidone is less than 30,000.
References Cited (Backward Citations)
GB1124285A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-06-28 | 1985-12-28 | 1986-06-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-06-28 | 1989-12-28 | 1990-06-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-06-28 | 1993-12-28 | 1994-06-29 | $7700.00 | Window Closed / Lapsed |