US4331651A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Depot body on the basis of silicone rubber and process for the preparation thereof
Assignee: Hoechst AG
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Filing: 1980-01-21
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Granted: 1982-05-25
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Expires: 2000-01-21
Abstract
Abstract Depot body on the basis of silicone rubber for the protracting release of active ingredients which contains from 2 to 50 weight %, relative to silicone rubber, of a release-promoting substance or a corresponding substance mixture in dissolved form, and a process for the preparation of such depot bodies. These depot bodies are suitable especially for the application of active substance onto the mucous membrane of the nasal vestibule of cattle.
Inventors
- 👤 Bernhard Reul
- 👤 Dietrich Hiller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:28
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/2036; A61K9/0012; A61K9/0043
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
185 words
A depot body on a silicone rubber carrier for the prolonged release of an active ingredient which comprises 2 to 50% by weight, based on the silicone rubber carrier, of a release-promoting substance or mixture thereof which is physiologically acceptable and only slightly soluble in water but soluble in silicone rubber, wherein said substance is an alcohol selected from the group consisting of 2-octyldodecanol, oleyl alcohol and phenylethanol, or an ester selected from the group consisting of myristic acid isopropyl ester, caprylic/capric acid laurylstearyl ester, lauric acid hexyl ester, propionic acid myristyl ester, isostearic acid ethyl-lauryl ester, oleic acid ethyl ester, acetic acid phenyl ester, benzoic acid benzyl ester, salicylic acid methyl ester, lauric acid mono-1,1-propanediol ester, fatty acid polyethyleneglycol ester, caprylic/capric acid-1,2-propanediol diester, caprylic/capric acid glycerol monoester, lauric acid glycerol diester, butyric acid glycerol triester, caprylic/capric/lauric acid glycerol triester, acetic/stearic/oleic acid glycerol triester, adipic acid dibutyl ester, sebacic acid dibutyl ester, phthalic acid ester, citric acid triethyl ester, or an ether selected from the group consisting of didecyl ether, fatty alcohol polyethyleneglycol ether, alkyl-aryl polyethyleneglycol ether and anisol or a ketone such as methylnonylketone.
Claim 2
Dependent Claim
185 words
A depot body on a silicone rubber carrier for the prolonged release of an active ingredient which comprises 2 to 50% by weight, based on the silicone rubber carrier, of a release-promoting substance or mixture thereof which is physiologically acceptable and only slightly soluble in water but soluble in silicone rubber, wherein said substance is an alcohol selected from the group consisting of 2-octyldodecanol, oleyl alcohol and phenylethanol, or an ester selected from the group consisting of myristic acid isopropyl ester, caprylic/capric acid laurylstearyl ester, lauric acid hexyl ester, propionic acid myristyl ester, isostearic acid ethyl-lauryl ester, oleic acid ethyl ester, acetic acid phenyl ester, benzoic acid benzyl ester, salicylic acid methyl ester, lauric acid mono-1,1-propanediol ester, fatty acid polyethyleneglycol ester, caprylic/capric acid-1,2-propanediol diester, caprylic/capric acid glycerol monoester, lauric acid glycerol diester, butyric acid glycerol triester, caprylic/capric/lauric acid glycerol triester, acetic/stearic/oleic acid glycerol triester, adipic acid dibutyl ester, sebacic acid dibutyl ester, phthalic acid ester, citric acid triethyl ester, or an ether selected from the group consisting of didecyl ether, fatty alcohol polyethyleneglycol ether, alkyl-aryl polyethyleneglycol ether and anisol or a ketone such as methylnonylketone.
Claim 3
Dependent Claim
31 words
The depot body of claim 1 wherein said release-promoting substance is selected from the group consisting of myristic acid isopropyl ester, lauric acid hexyl ester, caprylic/capric acid-1,2-propanediol diester or didecyl ether.
Claim 4
Dependent Claim
21 words
The depot body of claim 1 wherein said release-promoting substance is present in an amount of 5 to 40% by weight.
Claim 5
Dependent Claim
22 words
The depot body of claim 1 wherein said silicone rubber carrier is a single-component or two-component system cross-linked by addition or condensation.
Claim 6
Dependent Claim
16 words
The depot body of claim 1 wherein said silicone rubber carrier is dimethylpolysiloxane, dimethyldiphenylpolysiloxane or dimethylpolysiloxanol.
Claim 7
Dependent Claim
27 words
The depot body of claim 1 wherein said active ingredient is in dissolved or dispersed form and is at least partially wrapped in said silicone rubber carrier.
Claim 8
Dependent Claim
21 words
The depot body of claim 1 wherein said active ingredient is present in one or more chambers of said depot body.
Claim 9
Dependent Claim
22 words
The depot body of claim 1 wherein said active ingredient is present in said depot body in the form of a tablet.
Claim 10
Dependent Claim
15 words
The depot body of claim 8 wherein said tablet contains an effective amount of polyethyleneglycol.
Claim 11
Dependent Claim
24 words
The depot body of claim 1 wherein said active ingredient is selected from the group consisting of steroids, antibiotics, chemotherapeutic agents, prostaglandins and vitamins.
Claim 12
Dependent Claim
20 words
The depot body of claim 1 wherein said active ingredient is testosterone and esters thereof or trenbolone and esters thereof.
Claim 13
Dependent Claim
15 words
The depot body of claim 11 wherein said active ingredient is in admixture with estrogens.
Claim 14
Dependent Claim
29 words
The depot body of claim 1 adapted to effectively cooperate with a suitable device for applying said depot body to the mucous membrane of the nasal vestibule of cattle.
Claim 15
Dependent Claim
72 words
A process for the preparation of a depot body on a suitable silicone rubber carrier for the sustained release of an active ingredient which comprises dissolving 2 to 50% by weight, based on the silicone rubber carrier, of a release-promoting substance as defined in claim 15 in a silicone mixture prior to vulcanization, dissolving, dispersing or wrapping said active ingredient with said silicone rubber carrier and then vulcanizing said silicone rubber carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-05-24 | 1985-11-23 | 1986-05-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-05-24 | 1989-11-23 | 1990-05-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-05-24 | 1993-11-23 | 1994-05-25 | $7700.00 | Window Closed / Lapsed |